Company* (Country; Symbol)




Status (Date)


ILEX Oncology Inc. (ILXO)

Campath (FDA-approved)

Alemtuzumab; humanized monoclonal antibody directed against the CD52 antigen prevalent on leukemia and lymphoma cells

Multiple sclerosis

Clinical data showed Campath suppressed disease activity for a prolonged period in 36 patients with secondary, progressive MS (4/2)


Access Pharmaceuticals Inc. (AMEX:AKC)


A DACH polymer platinate

Ovarian cancer

Company began a Phase I trial in France and the Netherlands (4/3)

PhotoCure ASA (Norway; OSE:PH)

Metvix PDT (FDA-approved)

Photodynamic therapy; a cream that is absorbed into the cancer cells, followed by activation of the drug through illumination with a red light source called Curelight

Actinic keratosis

Company received Australian regulatory approval; Phase III data showed it to be efficacious in treating early squamous cell carcinoma (4/3)


Actelion Ltd. (Switzerland; SWX:ATLN)


An orally available dual endothelin receptor antagonist

Pulmonary arterial hypertension

Company submitted an NDA in Japan (4/8)

Endovasc Inc. (OTC BB:EVSC)

Liprostin intravenously

Alprostadil; a liposomal formulation of the prostaglandin E1(a) infused claudication

Critical limb ischemia and intermittent

Company plans to initiate a Phase II dose-ranging trial in Europe and Mexico (4/23)


Serono SA (Switzerland; NYSE:SRA)


Somatropin (rDNA origin) for injection

AIDS wasting

The Committee for Proprietary Medicinal Products recommended not granting marketing authorization for Serostim in the European Union (4/30)

Xenova Group plc (UK; XNVA)



Human papil-lomavirus-associated ano-genital intraepithelial neoplasia

Phase II data involving 29 patients in the UK showed the combination tion of the vaccines was safe and well tolerated and demonstrated clear clinical responses, even in women with longstanding disease (4/14)


CollaGenex Pharmaceuticals Inc. (CGPI)

Periostat (FDA-approved)

Doxycyline tablets 20 mg

Periodontal disease

Company was granted Swiss marketing approval (4/1); company received Canadian regulatory approval (4/3)

Isis Pharmaceuticals Inc. (ISIS)

ISIS 2302

Alicaforsen; an antisense inhibitor of intercellular adhesion molecule-1

Ulcerative colitis

Company initiated a Phase II trial (4/8)


* Privately held

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