Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

Atrix Laboratories Inc. (ATRX)

2/15

12/7

0.565S

$23

$13

BioMarin Pharmaceutical Inc. (BMRN)

11/12

12/7

8S

$12

$96.6

CV Therapeutics Inc. (CVTX)

1/4

12/4

2.875S

$52.50

$151

Inex Pharmaceutical Corp. (Canada; TSE:IEX)

11/26

12/13

6.15S

C$7

C$43 (US$27.4)

Neurocrine Biosciences Inc. (NBIX)

11/13

12/4

3.5S

$46.75

$163.6

Stressgen Biotechnologies Corp. (Canada; TSE:SSB)

12/4

12/20

6.7S

C$4.15

C$27.8 (US$17.6)

Theratechnologies Inc. (Canada; TSE:TH)

11/27

12/13

2.882S

C$10.25

C$29.5 (US$18.78)

Transkaryotic Therapies Inc. (TKTX)

12/13/00

12/13

3.2S

$39

$125.6

Transkaryotic Therapies Inc. (TKTX)

12/13/00

12/20

1S

$42

$42

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

ICOS Corp. (ICOS)

11/2

11/8

5.5S

$57

$313.5

ILEX Oncology Inc. (ILEX)

10/29

11/15

5.75S

$24

$138

Labopharm Inc. (Canada; TSE:DDS)

10/24

11/8

5.2S

C$6.75

C$35.1 (US$22.2)

ViroPharma Inc. (VPHM)

7/5

11/15

4S

$20.70

$82.8

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

BioMS Medical Corp. (Canada; CDNX:MS)

10/23

10/23

3.3U

C$2.50

C$8.25 (US$5.24)

Isis Pharmaceuticals Inc. (ISIP)

10/9

10/23

5.75S

$20

$115

Sicor Inc. (SCRI)

10/11

10/11

10S

$18.50

$185

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

AEterna Laboratories Inc. (Canada; AELA; TSE:AEL)

8/28

9/4

1.96S

C$8

C$15.7 (US$10)

Telik Inc. (TELK)

8/20

9/28

4.6S

$6.50

$29.5

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

Atrix Laboratories Inc. (ATRX)

2/15

8/9

3.45S

$23

$79.4

ConjuChem Inc. (Canada; TSE:CJC)

5/30

8/24

3.8S

C$6.25

C$23.95 (US$15.6)

Vion Pharmaceuticals Inc. (VION)

4/3

8/10

2.5S

$5

$12.5

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

Alteon Inc. (AMEX:ALT)

3/5

7/25

4.2S

$2.25

$10.125

Charles River Laboratories International Inc. (NYSE:CRL)

6/27

7/20

2S

$29

$58

Inflazyme Pharmaceuticals Ltd. (Canada; TSE:IZP)

6/19

7/9

4.125S

$2.70

C$11.125 (US$7.3)

Transkaryotic Therapies Inc. (TKTX)

12/13

7/2

3.52S

$28.46

$100.2

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

Arena Pharmaceuticals Inc. (ARNA)

6/5

6/22

4.75S

$27.50

$130.6

CV Therapeutics Inc. (CVTX)

4/23

6/7

2.02S

$49.50

$100

InterMune Inc. (ITMN)

6/4

6/29

4.3S (plus $149.5M in notes)

$32

$287

KS Biomedix Holdings plc (UK; LSE:KSB)

6/27

6/27

6S

3.15 (US$4.46)

19 (US$26.9)

Novogen Ltd. (Australia; NVGN)

6/1

6/1

10.55S

ND

11.2

Scios Inc. (SCIO)

5/30

6/22

5.75S

$21

$114

XOMA Ltd. (XOMA)

11/17

6/26

3S

ND

$43.3

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

NicOx SA (France; Nouveau Marche:NICOX)

5/23

5/23

1.02S

EUR68.20

US$48

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

Oxford Biomedica plc (UK; LSE:OXB)

3/12

4/17

5.3S

55 pence (US$0.78)

2.9 (US$4.13)

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

Charles River Laboratories International Inc. (NYSE:CRL)

2/15

3/16

3.5S

$19

$66.5

Hemosol Inc. (Canada; TSE:HML)

1/18

3/1

8.05S

$8.78

$70.7

Regeneron Pharmaceuticals Inc. (REGN)

1/26

3/20

6.5S

$25

$162.5

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

AltaRex Corp. (Canada; TSE:AXO; OTC BB:ALRXF)

11/16

2/13

4.4S

C$1.90

C$8.3 (US$5.46)

Aviron Inc. (AVIR)

12/18

2/2

4S (Plus $200M in convertible notes)

$50

$400

EntreMed Inc. (ENMD)

2/6

2/27

1.45S

$18

$24.5

Praecis Pharmaceuticals Inc. (PRCS)

1/26

2/15

7.6S

$24.562

$186.7

Company

Date Filed

Date Comm.

Shares/Units (M)

Price

Gross (M)

AnorMed Inc. (Canada; TSE:AOM)

1/23

2/6

1.5S

C$17

C$25.5 (US$16.88)

Genetronics Biomedical Ltd.

1/18

1/18

6.27S

C$1.35

C$8.46 (US$5.59)

Guilford Pharmaceuticals Inc. (GLFD)

11/20

1/16

2.656S

$17.50

$46.5