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Home » Newsletters » BioWorld

BioWorld

May 21, 2025

View Archived Issues
Art concept for medical research

Like glue: Orionis and Genentech begin their second collaboration

Orionis Biosciences Inc. is sticking with Genentech Inc. in a second deal to discover small-molecule monovalent glue therapies for treating cancer. Privately held Orionis is getting $105 million up front and could earn more than $2 billion in R&D, development, commercial and net sales milestones, plus royalties. The multiyear collaboration calls for Orionis to handle discovery and optimization of molecular glues, with Genentech in charge of later-stage preclinical and clinical development, regulatory filing and commercialization of any small molecules the partnership produces. Read More

Split adcom vote not what Urogen envisioned

More telling than the U.S. FDA’s Oncologic Drugs Advisory Committee’s 4-5 vote May 21 on the overall benefit-risk of Urogen Pharma Inc.’s UGN-102 (mitomycin) is that the panel’s urology specialists and the patient representative all voted yes, saying the drug would be an important alternative to what is often a continuing cycle of surgery for patients with recurrent low-grade intermediate-risk non-muscle invasive bladder cancer. Read More
Fertility art concept

Repronovo’s $65M series A gives new life to nolasiban

A drug that failed in a phase III trial in 2019 is being brought back to the clinic by Repronovo SA, a fertility and women’s health startup that has raised $65 million in a series A. The money will fund a phase II study of nolasiban in improving success rates in assisted reproductive technology, the same indication as the previous phase III failure. Read More
Bispecific antibodies with heavy chain in green and pink, light chain in blue and yellow

AP Bio heads to phase I with bispecific for HER2-resistant tumors

Although HER2-targeted therapies have become a mainstay in cancer treatment, some tumors evade them by stripping away the portion of the HER2 receptor that most therapies are built to recognize and bind to, but Taiwan’s AP Biosciences Inc. is developing bispecific antibody AP-402 to address treatment-resistant HER2+ cancers. Read More
Human aging illustration

Juvenescence's $76M+ to advance CD38, ketone drugs to clinic

Anti-aging specialist Juvenescence Ltd. reached the first close of its series B-1 at $76 million and said it is on course to close the round at $150 million in the third quarter of 2025. “The reason for the first close and not waiting for the very end is just so we can start to move the pipeline forward,” said Richard Marshall, CEO. “We’ve got molecules in and waiting to go, so the sooner we can get going on those, the better,” he told BioWorld. Read More
Immuneoncia Kosdaq debut

Cancer drug specialist Immuneoncia raises $24M in Kosdaq listing

Immuneoncia Therapeutics Inc. raised ₩33.9 billion (US$24 million) from its Kosdaq listing May 19. Shares closed at ₩7,500 – 108% higher than its offering price of ₩3,600 per share. Immuneoncia, a joint venture founded in 2016 between Seoul, South Korea-based Yuhan Corp. and San Diego-based Sorrento Therapeutics Inc., noted that the funds will support R&D operations until 2026. Read More

Appointments and advancements for May 21, 2025

New hires and promotions in the biopharma industry, including: Aardvark, Aligos, Grünenthal, Marea, Pepgen, Schrödinger, Shift, Slingshot, Upstream, Veraxa. Read More

Financings for May 21, 2025

Biopharmas raising money in public or private financings, including: AB Science, Omnio, Regenics, Regenxbio, Revolka. Read More

In the clinic for May 21, 2025

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Adrenomed, Annexon, Astrazeneca, Atai, Beckley, Boehringer, Bridgebio, Cingulate, Connect, Exact, Realta, Tourmaline, Trevi, Viridian. Read More

Other news to note for May 21, 2025

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Astrazeneca, Blueprint, Crispr, Esobiotec, Kancera, Recardio, Sirius, Vantai. Read More

Regulatory actions for May 21, 2025

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Alligator, Bayer, Quoin, Repair. Read More

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