Total: $1,211.07M

Company
(Symbol)#

(M)

Type Of
Financing

Number
Of

Shares,
Units

Or Warrants

Amount
Raised

(M)

Investors; Placement Agents;
Details
(Date)@


Acusphere
Inc.
(ACUS)

Registered
direct offering

9.259S and 3.7W

$25.5

Units consisting of one share and 0.4 warrants were sold at $2.75 each; the four-year warrants are exercisable at $3.11 per share; Cowen and Co. LLC was placement agent (12/7)

Advancis
Pharmaceutical

Corp.
(AVNC)

Private placement of stock

6S

$18

Shares were sold at $3 each to new and existing investors; Pacific Growth Equities LLC was lead placement agent; Susquehanna Financial Group LLP was co-agent (12/11)

Akesis
Pharmaceuticals

Inc.
(OTC BB:AKES)

Private placement of stock and warrants

1.383S and 0.207W

$0.8

The shares were sold at $0.60 each; the three-year warrants are exercisable at the same price; Akesis also established a $1M credit facility with Square 1 Bank (12/18)

Alexza
Pharmaceuticals

Inc.
(ALXA)

Product- specific vehicle

N/A

$50

Symphony Capital Partners LP and co- investors bought an interest in Alexza products AZ-002 and AZ-004, both in Phase IIa trials in central nervous system indications; Alexza has an option to reacquire all rights (12/4)

Alizyme plc
(UK; LSE:AZM)

Private placement of stock

18.12S

£14.5 ($28.3)

Shares were placed with UK institutional investors at 80 pence each; Piper Jaffray Ltd. was placement agent (12/1)

Antisoma
plc
(UK; LSE:ASM)

Private placement of stock

73.97S

£26.3 ($51.3)

The stock was sold to existing and new investors at 35.5 pence per share; Piper Jaffray Ltd. managed the deal; Needham & Co. LLC was co- manager (12/15)

Biomira Inc.
(Canada; BIOM)

Private placement of stock and warrants

9.63S and 1.926W

$13

Biomira sold units consisting of one share and 0.20 warrants at $1.35 each; the four-year warrants are exercisable at $1.86 per share; Rodman & Renshaw LLC was placement agent (12/13)

Callisto
Pharmaceuticals

Inc.
(AMEX:KAL)

Private placement of convertible stock and warrants

0.402S and 5.361W

$4.02

The company sold 402,100 Series A convertible shares, and 1.4M five-year warrants exercisable at $0.75 per share; it was the second tranche of a deal that totaled about $5.75M (12/27)

CeNeS
Pharmaceuticals
plc
(UK; AIM:CEN)

Private placement of stock

74.12S

£4.82 ($9.4)

The shares were placed at 6.5 pence each; JM Finn & Co. Ltd. was placement agent (12/4)

Ceragenix
Pharmaceuticals

Inc.
(OTC BB:
CGXP)

Private placement of notes and warrants

N/A and 1.16W

$5

The three-year, 9% notes initially are convertible into stock at $2.26 per share; the five-year warrants are exercisable at $2.37 per share; Stifel, Nicolaus & Co. Inc. was lead placement agent (12/11)

Cerus Corp.
(CERS)

Private placement of stock

3.904S

$26.1

The registered shares are being sold at $6.68 each; Banc of America Securities LLC was lead placement agent; Robert W. Baird & Co. Inc. was co-agent (12/6)

China
Biopharma

Inc.
(OTC BB:
CBPC)

Sale of convertible debt and warrants

N/A and 12W

$3

The $3M in 9% notes is convertible into common stock at $0.25 per share; warrants are exercisable at $0.30 and $0.40 per share; Melton Management Ltd. was agent for the deal (12/14)

Clinical Cell
Culture Ltd.

(UK; ASX:CCE)

Placement and share purchase plan

202.5S

A$13.77 ($11)

A$10M of the deal came from a share purchase plan underwritten by Potter Securities Ltd.; A$3.77M came from a sale to Hunter Hall Investment Management Ltd. and others; shares were sold at 6.8 cents each in both deals (12/7)

Cobalis Corp.
(OTC BB:CLSC)

Private placement of convertible notes and
warrants

N/A and 6.6W

$3.85

The 8% notes are convertible into stock at the lower of $0.99 or 90% of the lowest three-day average over 15 trading days; the warrants are exercisable at prices ranging from about $0.75 to $1 per share (12/21)

Columbia
Laboratories

Inc.
(CBRX)

Private placement of notes and warrants

N/A and ND

$40

The company sold convertible subordinated notes and warrants to existing institutional investors; terms of the deal were not disclosed (12/26)

CombiMatrix
Group
(CBMX)

Registered direct offering

9.8S and
11.76W

$10

9.8M units were sold at $1.02 apiece; each consists of one share and 1.2 warrants exercisable at $0.87 per share; Oppenheimer & Co. Inc. was placement agent (12/8)

Conjuchem
Biotechnologies

Inc.
(Canada;
TSX:CJB)

Sale of stock and warrants

185S and
92.5W

C$120.25($103)

Units in an offering were sold at C$0.65 apiece; each consists of one share and half a warrant; each whole warrant is exercisable for three years at C$1 per share; Dundee Securities Corp. and Sprott Securities Inc. were lead underwriters; others were Orion Securities Inc. and Versant Partners Inc. (11/28)&

Cytokinetics
Inc.
(CYTK)

Registered direct offering

5.286S

$37

The registered shares were sold at $7 each, a 6% discount to the Dec. 6 closing price; Lazard Capital Markets LLC was lead placement agent; JMP Securities LLC and Rodman & Renshaw LLC were co-agents (12/7)

Depomed
Inc.
(DEPO)

Equity
financing
commitment

N/A

N/A

Azimuth Opportunity Ltd. committed to purchase up to $30M in registered Depomed stock over two years, at a discount; any sales would be at Depomed's sole discretion (12/12)

EntreMed
Inc.
(ENMD)

Registered direct offering

10.728S

$17.2

Institutional investors purchased the registered shares at $1.60 each; ThinkEquity Partners LLC was lead placement agent; Rodman & Renshaw LLC was co-agent(12/13)

Enzo
Biochem Inc.

(NYSE:ENZ)

Registered direct offering

3.286S

$46

The registered stock was sold at $14 per share; Lazard Capital Markets LLC was placement agent (12/15)

EpiCept Corp.
(EPCT)

Private placement of stock and warrants

6.8S and 3.4W

$10

The stock was sold at $1.46 per share; the five-year warrants are exercisable, after six months, at $1.47 per share; Rodman & Renshaw LLC was placement agent (12/22)

EpiCept Corp.
(EPCT)

Equity
financing
commitment

N/A

N/A

Cornell Capital Partners LP committed to purchase up to $15M in EpiCept stock at a discount over three years; EpiCept will determine the timing and amount of any sales(12/22)

Favrille Inc.
(FVRL)

Equity financing commitment

N/A

N/A

Kingsbridge Capital Ltd. committed to purchase up to $40M of Favrille stock over three years, at times and in amounts to be determined by Favrille (12/20)

Galapagos
NV
(Belgium;
Euronext:GLPG)

Private placement of stock

3.464S

€31 ($40.7)

Shares were sold to institutional investors in the U.S. and Europe at €8.95 each; Kempen & Co., Fortis and Whitaker Securities managed the deal (12/22)

GenVec Inc.
(GNVC)

Registered direct offering

9.61S

$19.7

The registered stock was sold at $2.05 per share; Rodman & Renshaw LLC was placement agent (12/20)

Geron Corp.
(GERN)

Private placement of stock and warrants

5S and 4.875W

$40

The stock was sold at $8 per share; 1.875M warrants are exercisable at that price for 75 days; 3M warrants are exercisable after 180 days at an undisclosed premium; the company arranged the financing directly with investors (12/14)

GTx Inc.
(GTXI)

Registered direct offering

3.8S

$60.8

The registered stock was sold at $16 per share, a 4.7% discount to the Dec. 12 price; Lazard Capital Markets LLC was lead placement agent; Cowen and Co. LLC was co-agent (12/13)

ImmuneRegen
BioSciences

Inc.
(subsidiary
of IR BioSciences
Holdings Inc.;
OTC BB:IRBO)

Private placement of stock and warrants

ND

$5.5

The five-year warrants issued in the deal are exercisable at $0.50 per share; details on the financing were not disclosed (12/7)

Immunicon
Corp.
(IMMC)

Private placement of convertible notes

N/A

$30

The 6% notes are convertible into stock at $4.09 per share, or 7.33M shares; 1.47M warrants issued in the deal are exercisable at $4.09 per share; Deutsche Bank Securities Inc. was placement agent (12/5)

ImmuPharma
plc
(UK; LSE:IMM)

Private placement of stock and notes

4.35S

£4.71 ($9.2)

In one deal, 4.35M shares were sold at 62 pence each to funds managed by Jupiter, Martin Currie and Powe Capital; in another, ING Belgium provided €3M to ImmuPharma France SA in an interest-free bond, convertible for three years into 3.245M shares (12/21)

Introgen
Therapeutics

Inc.
(INGN)

Private placement of stock

4.99S

$24

The registered shares were sold at $4.80 each; Mulier Capital Ltd. was placement agent (12/14)

Lipid
Sciences Inc.

(LIPD)

Private placement of stock

4.593S

$6.2

Institutional investors led by RA Capital Management purchased the stock at $1.35 per share; Oppenheimer & Co. was placement agent (12/20)

MannKind
Corp.
(MNKD)

Offering of convertible notes

N/A

$115

The 3.75% notes due in 2013 were sold in a public offering; the intial conversion price is $22.47 per share; underwriters led by J.P Morgan Securities Inc. and Merrill Lynch & Co., along with Wachovia Capital Markets LLC, CIBC World Markets Corp. and Leerink Swann & Co. Inc., exercised their option to purchase $15M in notes (12/7)

Medicure
Inc.
(Canada;
AMEX:MCU)

Private placement of stock and warrants

19.9S and 3.98W

$25.9

Institutional investors purchased the shares at $1.30 each; the five-year warrants are exercisable at $1.70 per share; Deutsche Bank Securities Inc. was lead placement agent; A.G. Edwards & Sons Inc. and Montgomery & Co. LLC were co-agents (12/20)

Medivation
Inc.
(AMEX:MDV)

Registered direct offering

2.2S

$35.75

The registered stock was sold at $16.25 per share; Cowen and Co. LLC was lead placement agent; co-placement agents were Leerink Swann & Co., Rodman & Renshaw LLC and Emerging Growth Equities Ltd. (12/8)

Migenix Inc.
(Canada; TSX:MGI)

Bought-deal financing

2.51U

C$1.5
($1.3)

A Canadian investment dealer exercised its overallotment option on 2.51M additional units from a C$10M financing in November; totals in the C$11.5M deal were 19.263M shares and 9.631M warrants (12/6)

Neurogen
Corp.
(NRGN)

Registered direct offering

6.993S

$40

The registered shares were sold at $5.72 each, the Dec. 18 closing price; Pacific Growth Equities LLC was lead placement agent; co-agents were CIBC World Markets Corp., Leerink Swann & Co. and Merriman Curhan Ford & Co. (12/19)

Neuropharma
SA
(subsidiary
of Zeltia SA;
Spain; MSE:ZEL)

Private placement of stock

2.773S

€31.53 ($41.7)

Zeltia's stake in Neuropharma was reduced to 59% from 75.2% following the financing; the financing was managed by Banif (12/29)

NexMed Inc.
(NEXM)

Private placement of stock and warrants

13.317S and 5.327W

$8.65

Southpoint Capital Advisors and RA Capital Management purchased the stock at $0.6501 per share; the five-year warrants are exercisable at $0.79 per share (12/21)

NovaDel
Pharma Inc.

(AMEX:NVD)

Private
placement of
stock and
warrants

9.823S and
3.93W

$14.2

The stock was sold at $1.45 per share; the five-year warrants are exercisable at $1.70 per share; Oppenheimer & Co. was lead placement agent; Griffin Securities Inc. was co-agent (12/15)

Ondine
Biopharma

Corp.
(Canada;
TSX:OBP)

Bought-deal
financing

0.462S

C$0.74 ($0.64)

Underwriters of a C$10M financing in October exercised their option to purchase 0.462M additional shares; the deal totaled about 6.71M shares and C$10.74M in gross proceeds (12/7)

ProMetic
Life Sciences

Inc.
(Canada;
TSX:PLI)

Private placement of stock

65.138S

C$17.14 ($14.7)

In one deal, about 36.566M shares were sold at C$0.25 each; in a separate deal with Paradigm Capital Inc., about 28.57M shares were sold at C$0.28 each (12/28)

Protherics plc
(UK; LSE:PTI)

Private placement of stock and open offer

58.72S

£38.2 ($75)

Share were sold at 62 pence each; Nomura Code Securities Ltd. and Piper Jaffray Ltd. underwrote the deal (12/8)

Protox
Therapeutics

Inc.
(Canada;
CDNX:PRX)

Private placement of stock and warrants

1.75S and 0.875W

C$0.88 ($0.76)

The deal completes a C$10M financing round, the first part of which closed in November; units consisting of one share and half a warrant were sold at C$0.50 each; each one-year warrant is exercisable at C$0.65 per share (12/22)

pSivida Ltd.
(Australia;
PSDV)

Private
placement of
stock

14.23S and 28.46W

$2.9

The shares were sold at A$0.26 each (US$2 ADR equivalent); the four-year warrants are exercisable at A$0.26 per share (12/20)

ReGen
Biologics Inc.

(OTC BB:RGBI)

Private placement of stock and warrants

18.8S and 5.64W

$6.95

The stock was sold at $0.37 per share; the five-year warrants are exercisable at $0.55 per share; investors have rights to purchase another 18.8M shares on the same terms if ReGen's collagen scaffold device is approved (12/4)

RegeneRx Bio-
pharmaceuticals

Inc.
(AMEX:RGN)

Private placement of stock and warrants

5.306S and 2.122W

$9.55

The stock was sold at $1.80 per share; the warrants are exercisable at $2.75 per share; among the investors was Sigma-Tau Group; Piper Jaffray & Co. was placement agent (12/18)

SkyePharma
plc
(UK; SKYE)

Loan

N/A

£35 ($68.5)

The loan is repayable over 10 years, based on expected milestone and royalties payments from certain products; the interest is LIBOR plus 5.85% (12/27)

Xenomics
Inc.
(OTC BB:
XNOM)

Private placement of stock and warrants

1S and 0.5W

$1

An overseas institutional investor purchased the securities; the six-month warrants are exercisable at $1.25 per share (12/28)


Notes:

This chart does not include real estate or manufacturing plant financings, or debt deals done to replace existing debt.

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

Currency conversions are based on exchange rates at the time of the deal.

N/A = Not applicable; ND = Not disclosed.

& = News occurred in November but was not included in previous chart.

AIM = Alternative Investment Market; AMEX = American Stock Exchange; ASX = Australian Stock Exchange; CDNX = Canadian Venture Exchange; LSE = London Stock Exchange; MSE = Madrid Stock Exchange; MYSE = New York Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; TSX = Toronto Stock Exchange.