I. COMMENCED TRADING IN APRIL

Company
(Symbol)#

Date
Filed

Date
Comm.

Shares/
Units (M)

Price

Shares
Out
(M)@

Lead, Other
Underwriters

Gross
(M)

Post-Offering
Market
Cap (M)%


INITIAL OFFERINGS

Omrix Bio-
pharmaceuticals
Inc.
(OMRI)1

1/18/06

4/20/06

3.44S

$10

14.32

UBS Investment Bank, CIBC World Markets (co-lead), Leerink Swann & Co., Oppenheimer & Co.

$34.4

$143.2

Renovo
Group plc
(UK; LSE:RNVO)2

3/27/06

4/7/06

66.1S

£0.87

185.6

Goldman Sachs, Nomura Code, Securities (co-lead)

£57.5
($100.6)

£161.5
($283)

Targacept
Inc.
(TRGT)3

1/17/06

4/12/06

5S

$9

19.10

Deutsche Bank Securities, Pacific Growth Equities (co-lead), CIBC World Markets, Lazard Capital Markets

$45

$171.9

Vanda
Pharmaceuticals
Inc.
(VNDA)4

12/29/05

4/12/06

5.964S

$10

21.81

JP Morgan Securities, Banc of America (co-lead), Thomas Weisel Partners

$59.6

$218.1

Total: $239.6M

Number of IPOs in April: 4

Average value of April IPOs: $59.9M

Number of IPOs in 2006: 10

Total raised in IPOs in 2006: $526.38M

Average value of IPOs in 2006: $52.64M

FOLLOW-ON OFFERINGS

Company
(Symbol)#

Date
Filed

Date
Comm.

Shares/
Units (M)

Price

Shares
Out
(M)@

Lead, Other Underwriters

Gross (M)

Post-
Offering
Market
Cap (M)%


Acadia
Pharmaceuticals
Inc.
(ACAD)5

4/24/06

4/27/06

4.947S

$12

29.34

Banc of America, Lehman Brothers (co- lead), Piper Jaffray & Co., JMP Securities, Canaccord Adams Inc.

$59.4

$352.1

Labopharm
Inc.
(Canada;
TSE:DDS)6

4/18/06

4/28/06

11S

$8

54.90

Merrill Lynch & Co., Banc of America (co-lead), Canaccord Capital, Leerink Swann & Co., Orion Securities, Dundee Securities, Westwind Partners

$88

$439.2

Medarex
Inc.
(MEDX)7

4/3/06

4/7/06

10S

$11.75

121.9

Goldman, Sachs & Co., JP Morgan Securities (co-lead), Janney Montgomery Scott

$117.5

$1,432.3

OVERALLOTMENT OPTIONS

Amylin
Pharmaceuticals
Inc.
(AMLN)8

3/27/06

4/4/06

1.5S

$46.50

123.3

Morgan Stanley & Co. , Goldman, Sachs & Co. (co-lead), Bear, Stearns & Co., Lehman Brothers

$69.75

$5,733.5

Total: $334.65M

Number of follow-on offerings in April: 3

Average value of April follow-ons: $88.3M

Number of follow-on offerings in 2006: 20

Total raised in follow-ons in 2006: $1,999.17M

Average value of follow-ons in 2006: $99.96M


Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

@ This column reflects the shares outstanding following the offering, when disclosed.

% Market capitalization is calculated based on the offering price.

Currency conversions are based on exchange rates at the time of the deal. LSE = London Stock Exchange; TSE = Toronto Stock Exchange.

1. Omrix raised about $34.4M in an IPO of about 3.44M shares. Underwriters have an option to purchase up to 515,625 additional shares to cover overallotments.

2. Renovo raised £57.5M in an initial public offering. Totals include the underwriters' purchase of about 8.6M shares per their overallotment option.

3. Targacept raised $45M in an IPO of 5M shares. Underwriters have an option to purchase up to 750,000 additional shares to cover overallotments.

4. Vanda raised about $59.6M in an IPO of about 5.964M shares. Totals include the underwriters' purchase of 214,188 shares per their overallotment option.

5. Acadia raised $59.4M in a follow-on offering. Underwriters have an option to purchase up to 742,084 additional shares to cover overallotments.

6. Labopharm raised $88M in an offering in which it gained a Nasdaq listing. Underwriters have an option to purchase up to 1.65M additional shares to cover overallotments.

7. Medarex raised $117.5M in a follow-on offering from a shelf registration. Underwriters have an option to purchase up to 1.5M additional shares to cover overallotments.

8. Underwriters from Amylin's follow-on offering in March exercised their option to purchase 1.5M shares. The offering totaled 11.5M shares and $534.75M in gross proceeds.

II. FILED AND PENDING

Company
(Symbol/
Proposed
Symbol)#*

Date
Filed

Shares/
Units
(M)

Price
Range

Shares
Out
(M)
@

Lead, Other
Underwriters

Value
(M)


INITIAL OFFERINGS

Achillion
Pharmaceuticals
Inc.
(ACHN)1

4/3/06

N/A

N/A

N/A

Cowen & Co., CIBC World Markets (co-lead), JMP Securities

$75

BioMimetic
Therapeutics
Inc.
(BMTI)2

2/10/06

4.5S

$11-$13

N/A

Deutsche Bank Securities, Pacific Growth Equities (co-lead), First Albany Capital, AG Edwards

$54

BioNumerik
Pharmaceuticals
Inc.
(BNPI)3

6/9/04

5S

$14-$16

N/A

UBS Investment Bank, Needham & Co., Leerink Swann & Co., Punk, Ziegel & Co.

$75

Cleveland
BioLabs Inc.
(CBLI)4

2/17/06

N/A

N/A

N/A

Sunrise Securities

$13.8

Light Sciences
Oncology Inc.
(LSON)5

4/21/06

N/A

N/A

N/A

Cowen & Co., Wachovia Securities (co-lead), Jefferies & Co., Thomas Weisel Partners

$86.25

Molecular
Insight
Pharmaceuticals
Inc.
(MIPI)6

11/8/05

N/A

N/A

N/A

Piper Jaffray & Co., Cowen & Co. (co-lead), Oppenheimer & Co., Roth Capital Partners

$57.5

Novacea Inc.
(NOVC)7

2/10/06

6.25S

$11-$13

N/A

Bear, Stearns & Co., Credit Suisse Securities (co-lead), Pacific Growth Equities, HSBC Securities

$75

Perlegen
Sciences Inc.
(PERL)8

4/10/06

N/A

N/A

N/A

Lehman Brothers, Deutsche Bank Securities (co-lead), Piper Jaffray & Co., Allen & Co.

$115

PTC
Therapeutics
Inc.
(PTCT)9

3/31/06

N/A

N/A

N/A

Morgan Stanley & Co., JP Morgan Securities (co-lead), Pacific Growth Equities

$86.25

QuatRx
Pharmaceuticals
Co.
(QTRX)10

2/3/06

6S

$11-$13

N/A

Banc of America, Pacific Growth Equities, Cowen & Co. (co- lead), Lazard Capital Markets

$72

Replidyne Inc.
(RDYN)11

4/6/06

N/A

N/A

N/A

Merrill Lynch & Co., Morgan Stanley & Co. (co-lead), Cowen & Co., Pacific Growth Equities

$100


Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange; general shelf registration statements are not included until action is taken on the filing.

* Stock symbols for companies seeking to complete IPOs are proposed.

@ This column reflects the shares outstanding following the offering, when disclosed.

N/A = Not available, applicable or reported.

1. Achillion filed to raise up to $75M in an IPO.

2. BioMimetics filed to raise up to $50M in an IPO. Terms were proposed in April. The value is based on the midpoint of that estimate.

3. BioNumerik filed to raise up to $86.25M in an IPO. It later proposed selling 5M shares at $14 to $16 per share. The value is based on the midpoint of that price range.

4. Cleveland BioLabs filed to raise up to $13.8M in an IPO.

5. Light Sciences Oncology filed to raise up to $86.25M in an IPO.

6. Molecular Insight filed to raise up to $57.5M in an IPO.

7. Novacea filed to raise up to $75M in an IPO. Terms were proposed in April. The value is based on the midpoint of that estimate.

8. Perlegen filed to raise up to $115M in an IPO.

9. PTC Therapeutics filed to raise up to $86.25M in an IPO.

10. QuatRx filed to raise up to $86.25M in an IPO. Terms were proposed in April. The value is based on the midpoint of that estimate.

11. Replidyne filed to raise up to $100M in an IPO.