I. COMMENCED TRADING IN SEPTEMBER

INITIAL OFFERINGS

Company
(Symbol)#

Date
Filed

Date
Comm.

Shares/
Units (M)

Price

Shares
Out (M)

Lead, Other
Underwriters

Gross
(M)

Net
(M)

There were no initial public offerings in September.

Total: $0M

Number of IPOs in August: 0

Average value of August IPOs: $0M

Number of IPOs for 2001: 7

Total raised in IPOs in 2001: $207.05M

Average value of IPOs in 2001: $29.58M

FOLLOW-ON OFFERINGS

Company
(Symbol)#

Date
Filed

Date
Comm.

Shares/
Units (M)

Price

Shares
Out (M)

Lead, Other
Underwriters

Gross
(M)

Net
(M)

AEterna
Laboratories
Inc. (Canada;
AELA; TSE:AEL)¹

8/28

9/4

1.96S

C$8 (US$5.10)

32.3

National Bank Financial Inc.; Dundee Securities Corp.; Desjardins Securities Inc.

C$15.7 (US$10)

C$14.4 (US$9.2)

Telik Inc.
(TELK)²

8/20

9/28

4S

$6.50

26.9

Lehman Brothers Inc.; Legg Mason Wood Walker; UBS Warburg LLC; Lazard Freres & Co. LLC; Needham and Company Inc.

$26

$24.1

Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

TSE = Toronto Stock Exchange

¹ AEterna's underwriters have an overallotment option for 293,000 shares.

² Telik's offering includes up to 600,000 shares for overallotments.

Total: $36M

Number of follow-on offerings in September: 2

Average value of September follow-ons: $18

Number of follow-on offerings in 2001: 28

Total raised in follow-ons in 2001: $2,173.47M

Average value of follow-ons in 2001: $77.6M

II. FILED AND PENDING

INITIAL OFFERINGS

Company
(Symbol/
Proposed
Symbol)#*

Date Filed

Shares/
Units (M)

Price Range

Shares Out (M)

Lead, Other Underwriters

Value (M)

AgraQuest Inc.
(AGRQ)¹

8/3

N/A

N/A

N/A

Merrill Lynch & Co.; Stephens Inc.; First Union Securities Inc.

$75

APBiotech
(APBI; unit of
Nycomed
Amersham plc)²

10/3

18.2S

$15-17

208.6

Morgan Stanley Dean Witter (co-lead); Goldman, Sachs & Co. (co-lead); Chase H&Q; Salomon Smith Barney

$291.2

BioNumerik
(BNPI)³

3/2

N/A

N/A

N/A

Morgan Stanley Dean Witter; UBS Warburg LLC; SG Cowen Securities Corp.

$50

CombiMatrix
Corp. (CLMX)⁴

11/22

N/A

N/A

N/A

Salomon Smith Barney (co-lead); JP Morgan & Co. (co-lead)

$100

diaDexus Inc.
(DDXS)⁵

11/20

7S

$12-14

31.1

Lehman Brothers Inc.; CIBC World Markets Corp.; Robertson Stephens Inc.; Fidelity Capital Markets

$91

Northwest
Biotherapeutics
Inc. (NWBT)⁶

8/13

N/A

N/A

N/A

C.E. Unterberg, Towbin

$48.3

Ribapharm
Inc. (RIBA)⁷

5/15

18S

$13-15

N/A

UBS Warburg LLC; CIBC World Markets Corp.

$252

Xcyte
Therapies
Inc. (XCYT)⁸

12/22

N/A

N/A

N/A

SG Cowen Securities Corp. (co-lead); U.S. Bancorp Piper Jaffray (co-lead); Dain Rauscher Inc.; First Security Van Kasper Inc.

$86.2

ZymoGenetics
Inc. ⁹

9/10

N/A

N/A

N/A

Lehman Brothers Inc. (co-lead); Merrill Lynch & Co. (co-lead); Bear, Stearns & Co. Inc.; Pacific Growth Equities Inc.

$180

FOLLOW-ON OFFERINGS

Company
(Symbol/
Proposed
Symbol)#*

Date Filed

Shares/
Units (M)

Price Range

Shares Out (M)

Lead, Other Underwriters

Value (M)

Ariad Pharma-
ceuticals Inc.
(ARIA)¹⁰

6/22

4.5S

$4.79

34.6

N/A

$21.6

Cell Pathways
Inc. (CLPA)¹¹

2/7

N/A

N/A

N/A

N/A

$25

Cerus Corp.
(CERS)¹²

8/13

N/A

N/A

15.7

N/A

$300

Exelixis Inc.
(EXEL)¹³

7/30

N/A

N/A

49.2

N/A

$150

ICOS Corp.
(ICOS)¹⁴

6/26

N/A

N/A

53

N/A

$300

InSite Vision
Inc. (AMEX:
ISV)¹⁵

2/2

N/A

N/A

N/A

Ladenburg Thalmann & Co. (placement agent)

$40

Matrix Pharma-
ceuticals Inc.
(MATX)¹⁶

5/25

N/A

N/A

26

N/A

$30

Microcide Pharma-
ceuticals Inc.
(MCDE)¹⁷

2/12

N/A

N/A

N/A

N/A

$35

NeoThera-
peutics Inc.
(NEOT)¹⁸

1/3

N/A

N/A

20.8

N/A

$50

Tularik Inc.
(TLRK)¹⁹

8/14

N/A

N/A

49.2

N/A

$250

Valentis
Inc. (VLTS)²⁰

9/27

N/A

N/A

29.9

N/A

$45

ViroPharma
Inc. (VPHM)²¹

7/3

N/A

N/A

18.7

N/A

$300

Vysis Inc.
(VYSI)²²

8/8

1S

$25.96

11.2

UBS Warburg LLC; First Union Securities Inc.; Pacific Growth Equities Inc.

$26

III. WITHDRAWN AND POSTPONED

INITIAL OFFERINGS

Company
(Symbol/
Proposed
Symbol)#*

Date Filed/ Date Pulled

Shares/ Units (M)

Price Range

Shares Out (M)

Lead, Other Underwriters

Value (M)

NetGenics
Inc. (NTGC)²³

3/13/00
9/25

5.5S

$11-13

23.5

Chase H&Q; UBS Warburg LLC

$66

Senomyx Inc.
(SNMX)²⁴

2/21
9/6

N/A

N/A

17.4

Deutsche Banc Alex. Brown; Bear, Stearns & Co. Inc.; CIBC World Markets Corp.

$80

Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

* Stock symbols for companies seeking to complete IPOs are proposed.

N/A = Not available or reported.

AMEX = American Stock Exchange

¹ AgraQuest filed a registration statement with the SEC to raise $75M in an IPO.

² APBiotech's IPO value, $291.2M, is based on the sale of 18.2M shares at $16 each, the midpoint of the expected price range.

³ BioNumerik filed for a $50M IPO. The number of shares to be offered, the price range, and the number of shares outstanding were not disclosed.

⁴ CombiMatrix did not disclose any further details.

⁵ diaDexus' IPO value, $91M, is based on the sale of 7M shares at $13, the midpoint of the expected price range. The underwriters have an overallotment option for 1.05M shares.

⁶ Northwest filed for an IPO expected to raise $48.3M.

⁷ Ribapharm's IPO originally was proposed in June 2000. The company amended its prospectus on May 15. The value, $252M, is based on the offering of 18M shares at $14 each, the midpoint of the expected price range. The underwriters have an overallotment option for 2.7M shares.

⁸ Xcyte did not disclose any further details.

⁹ ZymoGenetics filed to raise $180M in an IPO.

¹⁰ Ariad's offering value is based on the proposed maximum offering share price of $4.79.

¹¹ Cell Pathways filed a shelf registration for the sale of $25M in common stock.

¹² Cerus filed to sell up to $300M of common stock and debt in a shelf offering.

¹³ Exelixis filed a shelf registration to sell up to $150M in common stock.

¹⁴ ICOS filed a shelf registration statement for up to $300M.

¹⁵ InSite filed a shelf registration to sell $40M in stock

¹⁶ Matrix filed a shelf registration covering up to $30M in securities.

¹⁷ Microcide filed a shelf registration for the sale of up to $35M in securities.

¹⁸ NeoTherapeutics filed a shelf registration covering the sale of debt securities, common stock, preferred stock, depository shares or warrants up to $50M. The company amended its prospectus April 19. In May, the company raised $6M in a private placement. In August, the company privately placed 600,000 shares, raising $2.01M.

¹⁹ Tularik filed to sell up to $250M in common stock and debt securities.

²⁰ Valentis filed to sell up to $45M worth of equity warrants, preferred and common stock through a shelf registration statement.

²¹ ViroPharma filed a universal shelf registration for $300M in mixed securities.

²² Vysis registered to sell 4M shares, 3M of which will be sold by shareholder BP plc. The value of the offering, $26M, is based on the closing stock price of $25.96 on Aug. 7. The underwriters have an overallotment option for 600,000 shares.

²³ NetGenics withdrew its IPO due to market conditions.

²⁴ Senomyx withdrew its IPO due to market conditions.