I. FINANCING OF PRIVATE BIOTECHNOLOGY COMPANIES: $267.78M

Company

Location

Date

Amt. (M)

Details

Amphora
Discovery
Corp.

Research Triangle Park, N.C.

9/27

$25

Amphora raised $25M with investors Arch Venture Partners, California Public Employees' Retirement System, CW Group, MPM Asset Management, OrbiMed Advisors LLC, Venrock Associates and Versant Ventures

Athenix
Corp.

Research Triangle Park, N.C.

9/11

$8

Athenix raised $8M in its first round led by Intersouth Partners and Polaris Venture Partners

Bio
Information
Technologies
Ltd.

Ramat Gan, Israel

9/10

$7.8

Bio Information completed its first round of funding for $7.8M; investors were OrbiMed Advisors LLC, Yozma and Fred Frank, the vice chairman of Lehman Brothers

Cellfactors
plc

Cambridge, UK

9/19**

£2.5
(US
$3.66)

Cellfactors raised US$3.66M in a private financing

Cumbre
Inc.

Dallas

9/20

$26

Cumbre raised $26M in a second round of financing from Pharma Vision AG and Vulcan Inc.

Entelos
Inc.

Menlo Park, Calif.

9/6

$25

Entelos raised $25M in a financing round led by Bear Stearns Health Innoventures LP; other investors were Earlybird, equity4life, Compaq Computer Corp., Abingworth Ventures, Boulder Ventures, Charles River Ventures and St. Paul Ventures

Euro-
Proteome
AG

Hennigsdorf, Germany

9/26**

EUR9.5
(US
$8.77)

EuroProteome completed its second financing round led by Earlybird Venture Capital and Heidelberg Innovation; other investors were Nextech Venture and Aventic Partners

Locus
Discovery
Inc.

Blue Bell, Pa.

9/7

$28

Locus raised $28M in the first closing of its third round; the company has the option to raise an additional $12M as part of a second closing; the financing was led by Wanger Asset Management LP, and included ING Furman Selz Capital Management LLC, INVESCO Global Health Sciences Fund, Delphi Ventures, Johnson & Johnson Development Corp., Tredegar Investments, Prism Venture Partners, Origin Capital, Amerindo Investment Advisers, ReqMed Co. and Cooper Hill Partners LLC

Macro-
Genics
Inc.

Rockville, Md.

9/25

$13.5

MacroGenics completed the second tranche of its Series A financing, bringing the total raised to $13.5M; investors included InterWest Partners LP and OrbiMed Advisors LLC

Merix
Bioscience
Inc.

Durham, N.C.

9/11

$39.5

Merix raised $39.5M in a second round of financing co-led by Sofinov and Techno Venture Management; other investors were ABN Amro Ventures BV, GeneChem Therapeutics Venture Fund LP, Oakwood Medical Investors, Pacific Horizon Partners, Sanders Morris Harris Inc., SHV Ventures, TFG Venture Capital AG & Co. KgaA, Aurora Funds Ventures, BD Ventures, Cordova Ventures, Harbinger/Aurora Ventures, Intersouth Partners, MDS Capital and Senmed Medical Ventures

NimbleGen
Systems
Inc.

Madison, Wis.

9/11

$9

NimbleGen raised $9M in a private round; investors included Venture Investors Management LLC, the State of Wisconsin Investment Board, Baird Venture Partners, Skyline Ventures, the Wisconsin Alumni Research Foundation and Tactics II Investments LLC

Protiva
Biothera-
peutics
Inc.

Vancouver, British Columbia

9/6

C14.5
(US
$9.3)

Protiva raised US$9.3M in an equity financing led by MDS Capital

PTC
Thera-
peutics

South Plainfield, N.J.

9/20

$40

PTC raised $40M in a second round of financing led by CSFB Private Equity, Vulcan Ventures Inc., and Bay City Capital; other investors were CDIB Biotech Inc., China Development Industrial Bank Inc., Delphi Ventures, HealthCap, The Manufacturers Life Insurance Company, NMT New Medical Technologies, Nova A/S and Pictet Global Sector Fund Biotech

Solexa
Ltd.

Cambridge, UK

9/24

US$17

Solexa raised $17M in a private equity financing round led by Schroeder Ventures Life Sciences; other investors were Oxford Bioscience Partners Boston, Amadeus Capital Partners and founding investor Abingworth Management

SynGenix
Ltd.

Cambridge, UK

9/13

£5
(US
$7.25)

SynGenix completed a US$7.25M private placement co-led by Technomark Medical Ventures and World Life Sciences plc; other investors were Yorkshire Funds Managers Ltd., Providence Investment Co., Generics Asset Management Ltd., Cambridge Research, Innovation Ltd. and the individual Martin Bloom

Note:

** Denotes the date the item ran in BioWorld International.

II. MILESTONE PAYMENTS AND EQUITY INVESTMENTS FROM EXISTING CORPORATE PARTNERS: $13M

Company (Symbol)#*

Partner (Country)

Amt. (M)

Triggering Event

Details (Date)


Avanir
Pharma-
ceuticals
Inc.
(NYSE:
AVN)

GlaxoSmithKline Consumer Healthcare (division of GlaxoSmithKline plc; UK)

$5

Milestone payment

Avanir received the payment relating to its agreement with GlaxoSmithKline on the marketing of Abreva in the U.S. (9/19)

Cortex
Pharma-
ceuticals
Inc.
(AMEX:
COR)

NV Organon (the Netherlands)

$2

Milestone payment

NV Organon decided to continue development of the Ampakine Org 24448 in a Phase II trial for schizophrenia, triggering the milestone payment (9/18)

Cubist
Pharma-
ceuticals
Inc.
(CBST)

Gilead Sciences Inc.

$3

Milestone payment

Cubist received a $3M milestone payment for completing patient enrollment in Phase III trials of Cidecin (9/6)

Cyto-
kinetics
Inc.*

GlaxoSmithKline plc (UK)

$2

Milestone payment

Cytokinetics earned the milestone payment for GlaxoSmithKline's selection of lead oncology compounds (9/21)

Human
Genome
Sciences
Inc.
(HGSI)

GlaxoSmithKline plc (UK)

ND

Milestone payment

Human Genome received a milestone payment for initiating Phase I trials with Lp-PLA2 inhibitor (9/6)

Ligand
Pharma-
ceuticals
Inc.
(LGND)

TAP Pharmaceutical Products Inc.

$1

Milestone payment

Ligand earned a milestone for TAP's decision to proceed with devleopment of LGD2226 (9/11)

Ligand
Pharma-
ceuticals
Inc.
(LGND)

Eli Lilly and Co.

ND

Milestone payment

Ligand earned a milestone payment as a result of Lilly filing an investigational new drug application with the FDA for LY519818 (9/26)

Paradigm
Genetics
Inc.
(PDGM)

Monsanto Co.

ND

Milestone payment

Paradigm reached a milestone in its commercial partnership with Monsanto, and will receive an undisclosed payment (9/26)


Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

* Denotes privately held company.

ND = Not disclosed

AMEX = American Stock Exchange; NYSE = New York Stock Exchange