Published March 27 & April 3 (EPO); March 21 & 28 (WO); April 3(GB)
Alabama, Univ. of Stem cell gene WO 96/08560
Birmingham, Ala. therapy
Hematopoietic stem cells transfected with adeno-associated viralvectors; for cellular gene therapy.
American Red Cross Transgenic WO 96/09377
Washington Factor VIII
Transgenic animals with Factor VIII and von Willebrand Factor geneexpression directed to milk.
Applied Res. Systems gp130 splice WO 96/09382
Splice-variant of gp130 that lacks the transmembrane domain,encoding gene; for preimplantation development.
Bayer Attenuated EPO 704 533
Leverkusen, Germany vaccination viruses
Influenza viral RNA molecules containing foreign genes; for makingattenuated vaccination viruses.
Bayer Insulin-dependent WO 96/09317
Gene for insulin-dependent membrane aminopeptidase, encodedprotein; for treating insulin resistance.
Baylor Coll. Med. Streptococcus WO 96/08569
Streptococcus cysteine protease, fragments, encoding genes; fordetection and immunotherapy.
Bergeron et al. Universal WO 96/08582
Sillery, Que. pathogen detection
DNA-based methods for universal detection of common bacterialpathogens and antibiotic resistance genes.
Boman, Hans Peptide antibiotic WO 96/08508
Gene for a peptide antibiotic that inhibits bacterial growth in man andanimals, encoding gene.
British Columbia, Univ. of Antigen WO 96/09380
Vancouver, B.C. presentation enhancement
Enhancing processing/presentation of MHC Class I molecules withantigens using transporter protein gene transfection.
British Technol. Grp. Muscular dystrophy GB 2 293 604&
London treatment WO 96/09373
Dermal fibroblasts implanted into muscle which causes dystrophinexpression; for treating muscular dystrophy.
California, Univ. of Inflammatory WO 96/09388
Oakland, Calif. bowel disease
Surface antigens from Campylobacter jejuni and antibodies to theseantigens; for inflammatory bowel disease treatment.
Cardiac CRC Nominees GAG-degrading WO 96/08559
St. Leonards, Australia antisense
Antisense molecules against glycosaminoglycan (GAG)-degradingenzymes; for disease treatment.
Ciba-Geigy Malfolded proteins WO 96/08561
Method of detection of malfolded proteins, measurement of amountof malfolding, detection of malfolding compounds.
City of Hope Multidrug resistance WO 96/08558
Duarte, Calif. ribozyme
Ribozyme for degrading genes involved in the multidrug resistancephenotype; for enhancing chemotherapy.
Contra Costa Fat globule WO 96/08565
Cancer Res. Fund antibodies
Walnut Creek, Calif.
Humanized and variant antibodies to a human fat globule antigen; forimmunodiagnostic methods.
Cytogen Abtides WO 96/09411
Antigen binding peptides (abtides) isolated from libraries by usingantigenic epitopes bound by antibodies.
Dompe IL-1 receptor WO 96/09323
l'Aquila, Italy antagonists
Genes for IL-1 receptor antagonists, encoded proteins; for enhancedinhibitory action.
Finkelstein et al. Topographic WO 96/09410
Aspinwall, Penn. genotyping
Isolation of a section from a fixed tissue specimen; for PCR-basedgene isolation and search for mutations.
Fuji Immunopharma Immunofusin WO 96/08570
Lexington, Mass. secretion
Production methods using immunoglobulin fusions for expressionand secretion of recombinant proteins.
Harvard Univ. EPH receptor WO 96/09384
Cambridge, Mass. ligand
EPH receptor ligand; for formation/maintenance of spatialarrangement of differentiated tissues in vertebrates.
Helsinki Univ. Tyrosine kinase WO 96/09381
Helsinki, Finland promoter
Promoter sequences for an endothelial cell receptor tyrosine kinase;for diagnosis and therapy.
Hitachi Chemical Chlamydia WO 96/09320
Antigenic polypeptide of Chlamydia pneumoniae, encoding gene,antibodies; for detection.
Human Genome Sciences Inositol WO 96/08557
Rockville, Md. monophosphatase
DNA encoding human inositol monophosphatase II, encoded protein;for treating psychotic/depressive disorders.
Human Genome Sciences Transcription WO 96/09311
Rockville, Md. factor IIA subunit
DNA encoding the small subunit of human transcription factor IIA,encoded factor; for transcription regulation.
Immunomedics Antibody WO 96/08506
Morris Plains, N.J. radiotherapy
Fusion proteins with targeting and labeling domains; for radioactivelytagging therapeutics.
Immunomedics PEG-radiolabeled WO 96/09325
Morris Plains, N.J. antibodies
PEG-modified radiolabeled antibodies; for tumor detection withreduced renal uptake and retention.
INSERM (Natl. Inst. Integrin chain WO 96/08564
Hlth. Med. Res.) a1 antibodies
Humanized antibody to integrin chain a1, encoding DNA, expressionmethods.
Japanese Cancer Inst. Steroid WO 96/09324
Tokyo hormone-like protein
Gene coding for a steroidal hormone-like protein, encoded protein;for cancer diagnosis and treatment.
Krebs Res. Inst. DNA damage WO 96/08571
Heidelberg, Germany detection
Gene for polyADP-ribose polymerase, host cells; for detection ofDNA-damaging substances.
Maryland, Univ. of Calcium-free WO 96/09396
College Park, Md. subtilisin mutants
Subtilisin mutants that do not require calcium for activity; encodinggenes.
Mass. Inst. Technol. Anti-sickling WO 96/09385
Cambridge, Mass. a-globin
Sickle cell gene therapy methods using high level expression of anti-sickling a-globin proteins in erythroid cells.
Mass. Gen. Hosp. Baculoviruses for WO 96/09074
Boston gene therapy
Recombinant gene expression in mammalian cells using abaculovirus vector; for gene therapy.
Mass. Gen. Hosp. Protein WO 96/09378
Overexpression of mammalian and viral proteins using genes withpreferred codon replacements.
Max Planck Inst. Modified WO 96/08562
Munich, Germany neurotropins
Genes for biologically active molecules derived from neurotropins,encoded proteins; for neurologic disease.
Max Planck Inst. IgA protease WO 96/09395
Pathogen antigenic proteins with similarities to IgA protease; fortreating autoimmune and viral diseases.
Merck Human WO 96/09375
Rahway, N.J. papillomavirus type 6A
DNA encoding human papillomavirus type 6A, encoded proteins; fordetection.
Miltenyi Biotech Fetal cell WO 96/09409
Auburn, Calif. enrichment
Enrichment of fetal cells from maternal peripheral blood usingantibody-coated magnetic beads; for genetic testing.
Mozetic Francky, A. Macrophage WO 96/09389
Ljubljana, Slovenia MIF
Gene for macrophage migration inhibitory factor (MIF), encodedprotein; for production in bacteria.
Murray et al. Pathogenic WO 96/08579
Palmerston North, mycobacteria detection
Probes to specific mycobacterial sequences; for detection ofpathogenic species.
NIH (Natl. Inst. Hlth.) 5-flurouracil WO 96/08568
Bethesda, Md. toxicity
Gene for dihydropyrimidine dehydrogenase; for detecting cancerpatient risk of toxic reaction to 5-fluorouracil.
NIH (Natl. Inst. Hlth.) Artificial organ WO 96/09372
Bethesda, Md. culture system
Endothelial and epithelial cell layers separated by a porousmembrane with both cell layers being bathed in nutrients.
NIH (Natl. Inst. Hlth.) 5HT receptor WO 96/09386
Bethesda, Md. alleles
Gene alleles of the serotonin 5HT receptor, encoded proteins,antibodies; for detection of allelic variation.
Otsuka Pharma Transcription EPO 704 526
Tokyo factor gene
Human transcription factor IIIA gene, encoded protein; fordiagnosing cancer and hereditary diseases.
Pasteur Inst. Leishmania EPO 703 295
BCG strain containing a fused leishmania membrane protein gene;for vaccination.
Pliva Modified insulin EPO 704 527
Zagreb, Croatia genes
Gene for insulin precursors with modified C-peptide, encodedprotein, preparation method.
Progenitor Hematopoietic WO 96/08510
Columbus, Ohio receptor
Human hematopoietic receptor, encoding gene, host cells engineeredto produce the protein; for prenatal testing.
Promega Magnetic mRNA WO 96/09313
Madison, Wis. purification
Purification of mRNA from other cellular nucleic acid by usingcolloidal magnetic particles.
Reynolds Technol. Squalene WO 96/09393
Winston-Salem, N.C. synthetase
Gene for squalene synthetase from Nicotania benthamiana, encodedprotein; for sterol synthesis.
Rhone-Poulenc Rorer T7 bacteriophage WO 96/08572
Antony, France vectors
Expression vectors based on T7 bacteriophage promoter; forrecombinant protein production.
Ribozyme Pharma Alipoprotein WO 96/09392
Boulder, Colo. (a) ribozymes
Ribozymes that cleave alipoprotein (a) mRNA; for treatment of heartdisease.
Schering Modified pallidipin WO 96/08563
Modified pallidipin, encoding gene; for inhibiting collagen-inducedplatelet aggregation.
SmithKline Beecham Human WO 96/09374 & 09408
King of Prussia, Penn. galactokinase
Gene for human galactokinase and variants, encoded proteins,expression vectors, host cells; for diagnosis and therapy.
Somatix Chimeric WO 96/09399
Alameda, Calif. adenovirus vectors
Chimeric adenovirus vectors with heterologous genes; for genedelivery and genetic disorder treatment.
Sumitomo Pharma Gene therapy EPO 704 534
Osaka, Japan vectors
Cotransfection with viral vectors containing the recombinase geneand its recognition sites; for gene therapy.
Systemix Genetically modified WO 96/09400
Palo Alto, Calif. stem cells
Genetic modification of stem cells using vectors containing thevesicular stomatitis virus G-glycoprotein.
Taisho Pharma Cancer growth EPO 703 242
Tumor cell proliferation inhibiting factor isolated from human tumorcells, method of production.
Taisho Pharma Hepatocyte WO 96/09383
Tokyo proliferating substance
Gene for hepatocyte proliferating substance, encoded factor,expression vector, host cells; for production.
Texas, Univ. of Photosensitive WO 96/09315
Austin, Tex. DNA cleavage
DNA cleavage by photosensitive texaphyrins that are targeted tospecific sequences with oligonucleotide probes.
Transgene Cellular implant WO 96/08574
Strasbourg, France gene therapy
Genetically modified cellular implant with therapeutic protein genecontained in an adenoviral vector.
Tosoh Collagen assay EPO 704 458
Type IV collagen antibodies; for incorporation into a kit fordetermining serum levels.
Tsang et al. Colon carcinoma WO 96/08514
Bethesda, Md. antibodies
Monoclonal antibodies against colon carcinoma-associated antigens;for detection and therapy.
U.S. Surgical Chimeric osteogenic EPO 704 532
Norwalk, Conn. proteins
Chimeric proteins with pharmacologically active and extracellularmatrix protein domains; for osteogenesis.
Upjohn Selectin ligands WO 96/09309
Oligosaccharide structure of a specific ligand for E- and P- selectin,derived ligands and carbohydrates.
Whitehead Inst. Biomed. Res. Magnetic WO 96/09379
Cambridge, Mass. DNA purification
Solid phase DNA purification and isolation using functional group-coated magnetic microparticles.
Wolf, H. Parvovirus vaccine WO 96/09391
Human parvovirus DNA sequences that code for the non-structuralprotein, encoded protein, antibodies; for vaccine.
Worcester Fdn. Biomed. Res. Differentiation WO 96/09387
Shrewsbury, Mass. factor cancer therapy
Expression vector with a gene encoding a differentiation factorreceptor; for tumorigenicity reduction.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.