u Immunomedics Inc., Morris Plains, N.J., was issued U.S. patent No.5,334,708 covering a method for producing an isotope-labeledmonovalent antibody fragment. The company also was issued U.S.patent No. 5,332,567 covering kits and methods for targetingdiagnostic agents to various infections.u Pharmaceutical Proteins Ltd., Edinburgh, U.K., was issued U.S.patent No. 5,322,775 covering its transgenic technology that uses abeta-lactoglobulin gene promoter to produce any protein in the milk ofall species of transgenic livestock and the recovery of the protein fromthe milk.

EUROPEAN PATENT DISCLOSURES

Published July 20 & 27 (EPO); July 21 (WO)Abbott Labs Sorbitol-induced WO 94/15942Abbott Park, Ill. yieldsYeasts with sorbitol dehydrogenase- based expression vector,heterologous protein production induced by medium sorbitol.Ajinomoto Recombinant WO 94/15963Tokyo L-amino acidsGene coding for Brevibacterium cell cortex protein used to make aproduction strain for L- amino acid fermentation.Alexion Pharm. Complement WO 94/16062New Haven, Conn. inhibitionHerpesvirus complement regulatory pro tein gene sequenceshomologous to human complement inhibitory protein CD59.Amgen Thrombocytopenia/ EPO 607 925Thousand Oaks, Calif. leukemia modelsTransgenic mice with megakaryocyte leukemia and/or decreasedplatelet counts; models for thrombocytopenia and leukemia.Bergmann et al. Antisense HIV WO 94/16066Hamburg, Germany therapyAntisense versions of gene implicated in HIV replication; for diagnosisand therapy of HIV.Biogen Anti-inflammation WO 94/16094Cambridge, Mass. antibodiesRecombinant anti- VLA4 antibodies, including humanized anti bodies;for diagnosing and localizing inflammation sites.Biosource Genetics Plant RNA virus WO 94/16089Vacaville, Calif. vectorVector with plant RNA virus chimeric gene; for high level expressiondue to RNA amplification properties of virus.Biotechnological Inst. Lactic acid WO 94/16086Lyngby, Denmark promotersLactic acid bacteria strains with vector containing lactic acid regulatedpromoter linked to a structural gene.British Bio-Technology Protein particle WO 94/16084Oxford, England deliveryChimeric particle- forming protein, yeast retrotransposon or RNAretrovirus GAG protein fused to antigen; for delivery.Burcoglu, Arsinur Oligodeoxy- WO 94/15621Pittsburgh nucleotide therapyOligodeoxynucleotides for treatment of disease states, dosage adjustedfor disease marker fluctua tions.California, Univ. of Targeted anti- WO 94/15953Oakland, Calif. thromboticTherapeutic platelets loaded with RGD/KGD- containing peptidelinked to anti-thrombotic or anti-atherosclerotic agent.Chemo-sero-thera Chimeric anti- HIV WO 94/15969Kumamoto, Japan antibodyAnti-HIV antibody made by fusing mouse vari able region sequencesfor H and L chains with human immuno globulin gene.Ciba- Geigy Disease resistant WO 94/16077Basel, Switzerland plantsPlants selected by measuring expression of systemic acquiredresistance genes; for breeding disease resistant plants.CTRC Research Fdn. DNA color imaging WO 94/16104San Antonio, TexasColor imaging system for stained DNA that has been gravita tionallystretched to an essentially linear, 2D form.

Dana- Farber Cancer Inst. ICAM screens EPO 606 518BostonAntibodies against intercellular adhesion molecules (ICAM- 1); theiruses of se antibodies in screening assays for ICAMs.Dana- Farber Cancer Inst. Immuno- WO 94/15964Boston suppressant screenDNA and protein sequence for T cell DNA binding protein (NF- ATp);for screening immunosuppressant compounds.Dana- Farber Cancer Inst. Epithelial- specific WO 94/16057Boston expressionVector containing DF3 enhancer and gene for heterologous protein; fortissue- selective expression in epithelium.European Community Fermented WO 94/16082Plateau de Kirchberg, foodstuffsLuxembourgX- prolyl-dipeptidyl-aminopeptidase releases X- Pro dipeptides fromprotein N- terminus; for preparing fermented foodstuffs.Exemplar Reducing host WO 94/16065Worcester, Mass. rejectionCells expressing E19 protein which alters MHC class I cell surfaceantigen presentation; for reducing host rejection.Exemplar Antitumor WO 94/16080Worcester, Mass. drug assayTumor cell introduced into organism with transformation sensitivereporter unit; for testing antineoplastic drugs.Foldes et al. CNS EAA receptors EPO 606 734Willowdale, Ont.Cell lines expressing recombinant excitatory amino acid (EAA)receptors; for identifying EAA receptor modulators.Genetics Institute Modified M- CSF WO 94/16075Cambridge, Mass.Macrophage-CSF coding sequence lacking C- terminal propep tide,biolog ical activity unaffected; for efficient production.Genetics Institute Cloned enterokinase WO 94/16083Cambridge, Mass.DNA and protein sequences of enterokinase.Green Cross Mutant host EPO 606 917Osaka, Japan strainMutant bacterial strain grown in medium with methanol and glucose;for making large amounts of heterologous pro tein.Idemitsu Kosan Anti- ceruloplasmin EPO 606 516TokyoAnti-ceruloplasmin monoclonal antibody against active form,neutralizes peroxidase activity; Wilson's disease diag nosis.Immulogic Pharm. Dog dander WO 94/16068Waltham, Mass. allergensDNA and protein sequences for allergenic proteins and pep tides fromdog dander; for diagnosing allergic sensitivity.INRA (Natl. Inst. Virus- resistant WO 94/16087Agron. Res.) Paris plantsDNA fragments expressing proteins from plant polyvirus inserted intoplant tissues; for virus resistance.INSERM (Natl. Inst. Serotoninergic WO 94/16067Hlth. Med. Res.) Paris therapiesDNA and protein sequences of serotoninergic receptors; for treatmentof neurologic and gastroenterologic disorders.Intracell Therapeutics Mutated CD4 WO 94/16072Guilford, Conn.Vectors encoding mutated soluble CD4 protein controlled by HIVregulatory elements; for inhibiting HIV spread.Jarvik, J. W. Exon molecular WO 94/16092Pittsburgh tagMolecular tag formed by DNA structure inserted into intron that thenmakes two hybrid introns with new inserted exon.Johns Hopkins Growth WO 94/15949,Sch. Med. Baltimore differentiation 965, 966DNA and protein sequences of growth differentiation factors 3, 5 and9; diagnostic and therapeutic methods using GDFs.Koster, Hubert Spectrometric WO 94/16101Concord, Mass. sequencingSanger sequencing strategy using base- specific termination followedby nested fragment analysis by mass spectrometry.Leiden, State Univ. Lectin binding WO 94/16088Leiden, Nether lands mutationSurface loop mutated legume lectin with diminished binding activity;for reduced anti-nutritional effect.Mass. Gen. Hosp. Hepatocyte WO 94/15459Boston transfectionHepatocyte preparation enriched for specialized hepatocytes,specialized hepatocyte transfection; for transplanta tion.Mass. Eye & Ear Infirm. Retinoblastoma EPO 608 004Boston diagnosisGenetic material from normal retinoblastoma; used to diagnosepresence of defective retinoblastoma alleles.Mass. Inst. Tech. Drosophila apoptosis WO 94/16071Cambridge, Mass. genesIdentification of two cell death genes on Drosophila chromo- some 3;for assaying apoptotic abnd necrotic cell death.Molecular Tool Stable WO 94/16090Baltimore polynucleotidesModified nucleotides used to make single- stranded nucleic acidmolecules that are resistant to 5' - 3' exonucleases.Mycogen Corn pest WO 94/16079San Diego resistanceGenes for Bacillus thurigiensis d-endotoxins, mutant endotoxins andtransformed hosts; for corn rootworm control.New England Biolabs Recombinant Not I EPO 607 005Beverly, Mass. enzymeCoding sequence for Not I restriction endonuclease inserted into hoststrain; for producing Not I restriction enzyme.Ono Pharmaceutical Signal peptide EPO 607 054Osaka, Japan libraryConstruction of cDNA library selective for signal peptides; foridentifying agents to treat anemia and other diseases.Ono Pharmaceutical Mevalonic acid EPO 608 117Osaka, Japan immunodetectionMono- and Polyclonal antibodies specific to mevalonic acid;immunoassay for determination of mevalonic acid.Oregon Hlth. Sci. Univ. Furin protease WO 94/16073Portland, Ore. inhibitionVariants of a- antitrypsin that inhibit furin endoprotease activity; forpreventing viral/bacterial protein processing.Paravax Heartworm control WO 94/15593Ft. Collins, Colo.Sequences encoding parasitic helminth proteins that activate immuneserum, protein, antibodies; for infec tion preven tion.Pioneer Hi- Bred Intl. Antifungal WO 94/16078Des Moines, Iowa a- hordothioninAntifungal protein a- hordothionin modified for lysine en richment bylysine residue substitution, function retained.Public Hlth. Res. Inst. RNA sandwich WO 94/16105,New York assays 106, 108Nucleic acid sandwich hybridization assays for RNA targets usingRNA- directed RNA ligase/chain reaction amplification.Schering Inhibiting Ras WO 94/16069Kenilworth, N.J. proliferationRas- associated gap proteins that block abnormal intracellularsignalling; for inhibiting uncontrolled proliferation.Schwaller, Manfred HIV vaccine WO 94/16081Pforzheim, Germany productionHIV surface protein gp160 oligomer and ectodomains obtained byprotease digestion of chimeric gp160; for AIDS vaccines.Florida, Univ. of Leukocyte- derived WO 94/16070Tampa, Fla. GFLeukocyte- derived growth factor 2 having PDGF- like activity; forstimulating cell growth and wound heal ing.Spielberg, Theodore E. Hormone WO 94/15466Wellesley, Mass. deficiencyIn vitro/in vivo peptide hormone- deficient endocrine cell transfectionto produce hormone; for hormone deficiency.Synaptic Pharmaceutical Abnormal WO 94/15618Paramus, N.J. Betaine/GABASequence encoding betaine/GABA transporter, antibodies to protein,transgenic animals; for screening abnormalities.Thomas Jefferson Univ. Dry DNA sequencing WO 94/16107PhiladelphiaDNA sequencing with Bst polymerase in a dried state.Transgne Yeast expression EPO 607 080Strasbourg, France cassetteExpression cassette containing insect pro sequence in yeast strains; forsecretion of heterologous pro teins [in French].Triplex Pharmaceutical Targeted DNA WO 94/15616The Woodlands, Texas damageTriplex forming oligonucleotides linked chemically, attached DNAdamaging agent; for diseases responsive to DNA damage.Washington Univ. Interleukin- 14 WO 94/16074St. LouisDNA/protein sequences of high molecular weight B- cell growth factor(interleukin- 14); transgenic animals with or without it.Woods Hole Growth in WO 94/16063Oceanographic Inst. cAMP/cGMPWoods Hole, Mass.Periplasmic 3', 5'- cyclic nucleotide phospho diester ase gene fromgram negative bacteria; for growth solely in cAMP/cGMP.Yeda R & D TNF modulation EPO 606 869Rehovot, IsraelPromoter DNA sequences of p55 tumor necrosis factor (TNF) receptor; for modulating TNF function.Zeneca Plant disease WO 94/16076London preventionAntimicrobial- protein- producing microorganism used as a plantendosymbiont; for preventing plant disease.Zymogenetics Wound healing WO 94/16085SeattleHybrid proteins having cross- linking and tissue- binding activities; forwound healing and tissue sealing._ Compiled by Chester A. Bisbee

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