Adverse reactions to recombinant cytokines are reported in thecorrespondence sections of two medical journals this week.Two women experienced allergic reactions when treated withAmgen's G-CSF, and GM-CSF made by Genetics Instituteappeared to intensify a case of rheumatoid arthritis.

Letters in the New England Journal of Medicine noted that bothpatients receiving granulocyte colony stimulating factor hadbeen treated concurrently with other drugs. Amgen said it didnot consider significant two adverse reactions out of 20,000G-CSF recipients.

The adverse reaction to granulocyte macrophage colonystimulating factor was reported in a letter to the Britishjournal The Lancet by doctors at University Hospital inGroningen, Netherlands, and scientists at Sandoz in Basel,Switzerland. "Rheumatoid arthritis patients will need specialattention with respect to the type of cytokine or combinationof cytokines given to avoid exacerbation of symptoms," thedoctors said.

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