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Home » Topics » Immunotherapy » CAR T

CAR T
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Liver and DNA
Immuno-oncology

Armored anti-GPC3 JW-004 shows increased potency against HCC

May 28, 2025
No Comments
Hepatocellular carcinoma (HCC) is a fatal cancer and the third cause of cancer-related deaths worldwide. Current therapies have focused on CAR T cells for treating HCC. Glypican-3 (GPC3) is a membrane protein that is overexpressed in HCC but not in healthy adult liver tissue, thus becoming a promising therapeutic target for HCC management.
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3D rendering of CAR T therapy in cell
Immune

Sail Biomedicines presents in vivo CAR T platform for autoimmune diseases

May 27, 2025
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To address the various limitations of traditional CAR T therapy in autoimmune disease, Sail Biomedicines Inc. has developed an in vivo CAR T platform that enables in vivo transient programming of patient immune cells.
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Ovarian cancer illustration
Immuno-oncology

Dual knockout of DGK-α and -ζ enhances TAG-72 CAR T-cell antitumor efficacy in ovarian cancer

May 22, 2025
No Comments
Ovarian cancer remains a leading cause of cancer-related deaths among women, with high recurrence rates and resistance to chemotherapy. CAR T-cell therapies present limited efficacy in solid tumors due to tumor heterogeneity and immune suppression in the tumor microenvironment.
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CAR T cell attacking cancer cells
Immuno-oncology

PRGN-3008 exerts potent antitumoral activity and surpasses conventional CAR T

May 20, 2025
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CAR T-cell therapy for B-cell malignancies has still to be improved regarding durability, manufacturing complexity or toxicity, among others. Precigen Inc. has presented data regarding the preclinical development and efficacy of PRGN-3008, a PD-1-expression inhibitor cell therapy targeting CD19 that was built in a next-generation ultra CAR T platform.
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CAR T-cell therapy in acute lymphoblastic leukemia
Immuno-oncology

Third-generation K12 CAR T shows strong activity in CD7+ T-cell malignancies and relapsed AML

May 13, 2025
No Comments
A study has demonstrated the potential of a novel ligand-based CAR T-cell therapy for targeting CD7-positive T-cell malignancies, including T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphomas. The receptor CD7 is a prominent target antigen, being expressed in around 95% of T-ALL, 50% of peripheral T-cell lymphomas and 10% of acute myeloid leukemias.
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Immuno-oncology

Improving CAR T cell performance 'ALA-CART'

April 11, 2025
Although CD19-directed CAR T cells can initially induce remission in 70-90% of patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL), post-CAR relapses are frequent. These relapses are driven by insufficient persistence of CAR T cells, allowing for antigen-positive B-ALL re-emergence and loss of the targeted epitope either in isolation or as part of lineage-switching.
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3D rendering of CAR T therapy in cell
Immuno-oncology

Sherpabodies: A versatile antigen recognition platform to enhance CAR T-cell therapy in solid tumors

April 3, 2025
Although CAR T-cell therapies have reached significant clinical success in hematological malignancies, their utility in solid tumors remains limited. One of the main challenges is the scarcity of truly cancer-specific antigens for precise targeting of solid tumors. The use of engineered small, specific antigen-binding domains, such as nanobodies, could be a potential strategy to improve the specificity and efficacy of CAR T cells against solid tumors.
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Art concept for hematologic cancer
Immuno-oncology

French grant supports Allogenica’s universal CAR T therapy for CD19-positive hematologic cancers

March 20, 2025
Allogenica SAS has been awarded a €2.5 million (US$2.7 million) grant under the French government’s France 2030 program to help advance its universal CAR T candidate, XL-001, for CD19-positive hematologic cancers.
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CAR T cells attacking cancer cell
Cancer

ZP4, a promising new CAR T-cell therapy target for TNBC

March 18, 2025
A team at Baylor College of Medicine conducted research to identify novel cell-surface cancer/germline antigens (CGAs) expressed in triple-negative breast cancer (TNBC) that could serve as targets for development of CAR T therapies against this disease.
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3D illustration demonstrating CAR T therapy
Immuno-oncology

Bioheng Therapeutics’ CD7-targeted universal CAR T-cell therapy gains IND clearance

March 5, 2025
Bioheng Therapeutics US LLC has obtained IND approval from the FDA for CTD-402, a CD7-targeted universal CAR T-cell therapy, for the treatment of pediatric and adult patients with relapsed or refractory T-cell acute lymphoblastic leukemia/lymphoma.
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