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Home » Topics » Immunotherapy » CAR T

CAR T
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Neurology/psychiatric

Poltreg studies CAR-Treg cells in neuroinflammatory mouse model

Sep. 26, 2024
Poltreg SA has initiated a preclinical study with CAR-Treg cells in a humanized mouse model of neuroinflammatory disease.
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CAR T cell with implanted gene strand

ECTRIMS 2024: Driving a fast CAR on the MS road and beyond

Sep. 23, 2024
By Coia Dulsat
Chimeric antigen receptor (CAR) T-cell therapy moved the needle at the 2024 ECTRIMS (European Committee for Treatment and Research in Multiple Sclerosis) congress and will continue to do so – not just in multiple sclerosis (MS), but in other autoimmune diseases as well.
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Multiple sclerosis
Neurology/psychiatric

Immpact Bio’s CD19/CD20 bispecific CAR T-cell therapy obtains IND clearance for MS

Aug. 22, 2024
Immpact Bio USA Inc. has obtained IND clearance from the FDA for IMPT-514, a CD19/CD20 bispecific chimeric antigen receptor (CAR) T-cell therapy for the treatment of adult patients with multiple sclerosis (MS). A phase I trial will focus on patients who have suboptimal disease control despite prior treatment with high efficacy disease-modifying therapies in all forms of MS.
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Multiple sclerosis-damaged myelin
Neurology/psychiatric

Azer-cel gets IND clearance in multiple sclerosis

Aug. 12, 2024
Precision Biosciences Inc. has announced that its experimental allogeneic T cell therapy azercabtagene zapreleucel (azer-cel) for the treatment of multiple sclerosis (MS) has received IND clearance from the FDA.
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3D rendering of CAR T therapy in cell
Immune

BCMA-targeting CAR T cell cleared for clinic by China’s NMPA

Aug. 12, 2024
CSPC Pharmaceutical Group Ltd. has received clearance from China’s National Medical Products Administration (NMPA) to conduct clinical trials in China with its BCMA-targeting CAR T cell SYS-6020 for systemic lupus erythematosus (lupus) in China.
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Art concept for inflammation in the intestines
Gastrointestinal

TRX-103 cleared for clinic in treatment-refractory Crohn’s disease

Aug. 9, 2024
Tr1x Inc. has announced that the FDA has cleared its IND application for its engineered Tr1 Treg cell therapy TRX-103 for treatment-refractory Crohn’s disease.
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Stem-cells2.png
Cancer

Shinobi gets grants, investments for up to $127M

Aug. 7, 2024
Shinobi Therapeutics Inc. has been awarded non-dilutive grant funding of up to $59 million by the Japanese Agency for Medical Research and Development (AMED).
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CAR T cells attacking cancer cell
Immuno-oncology

ROBO1 CAR T cells fight tumors and metastases in brain

Aug. 7, 2024
Investigators at McMaster University have developed a CAR T cell that targeted roundabout guidance receptor 1 (ROBO1).
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CAR T cell attacking cancer cells
Cancer

Removing CD5 'brake' on CAR T cells increases antitumor efficacy

Aug. 2, 2024
By Mar de Miguel
To be successful, CAR T-cells need a balance between being effective and overkill. Researchers from the University of Pennsylvania and Vittoria Biotherapeutics Inc. have eliminated the CD5 signaling pathway of their CAR Ts to prevent the immunosuppressive brake effect. In return, this improved their proliferation and antitumor activity in T cell lymphomas.
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3D illustration demonstrating CAR T therapy
Cancer

In situ CAR T receives IND clearance

Aug. 1, 2024
Umoja Biopharma Inc. has received clearance from the FDA to begin a first-in-human trial of its CAR T product UB-VV111. The company expects to dose the first patient by the end of 2024.
Read More
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