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BioWorld - Sunday, March 26, 2023
Home » Topics » Newco news

Newco news
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Elderly woman holding illustration of brain with missing puzzle piece
Newco news

‘Not a slowdown, a reversal’: Truebinding tackling Alzheimer’s via galectin-3

March 17, 2023
By Jennifer Boggs
No Comments
In Alzheimer’s, the amyloid beta hypothesis has proved most persistent in terms of drug development efforts to date, but aggregation of other pathogenic factors – phosphorylated tau (p-tau), APOE4, TREM2 and alpha-synuclein, for example – have also emerged as hallmarks of the disease. It’s that aggregation that seven-year-old Truebinding Inc. aims to target with its lead program, TB-006, a monoclonal antibody against galectin-3.
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Newco news

A $4 million handshake with investor helps propel First Wave Biopharma’s CF offering

March 16, 2023
By Caroline Richards
No Comments
An investor has seen promise in First Wave Biopharma Inc.’s targeted, systemic gastrointestinal disease biotherapeutics, offering $4 million in a private placement as enrollment picks up pace in a phase II trial for the company’s lead candidate, adrulipase.
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White Euro symbol on blue background
Newco news

Teitur Trophics targeting neurodegenerative disease with €28M series A round

March 14, 2023
By Nuala Moran
No Comments
Newco Teitur Trophics ApS has raised €28 million (US$30.1 million) in a series A with which it will lay out a new route to targeting sortilin in the treatment of neurodegenerative diseases. The company is targeting the sortilin-related Vps10p domain containing receptor, which plays a role in regulating a number of pathways involved in the control of neuronal viability and function.
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Concept art for RNA interference, gene silencing.
Neurology/Psychiatric

Switch Therapeutics launches with focus on conditionally activated siRNA molecules

March 14, 2023
No Comments
Switch Therapeutics Inc. has announced its launch following US$52 million of financing. The company was founded on the premise of a new type of RNA medicine that integrates nucleic acid nanotechnology and RNA interference (RNAi) science.
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Targets with arrows
Newco news

Flagship puts $50M toward targeted tissue-homing tech startup

March 10, 2023
By Caroline Richards
No Comments
In an ideal world, when a patient takes a medicine, it acts only at the specific site of disease in the human body whilst sparing healthy tissues. But it almost goes without saying that with many drug regimens, side effects or complications are part of the package. Working behind the scenes to address this limitation over the past couple of years, Cambridge, Mass.-based venture capital company Flagship Pioneering is now publicizing its platform of “programmable medicines” that directly and precisely target diseased tissue, funnelling $50 million of investment in the technology and recognising its achievements formally through the launch of Ampersand Biomedicines.
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Abraham Ceesay, CEO, Rapport
Newco news

Rapport launches with $100M series A plus J&J precision neuroscience platform

March 7, 2023
By Cormac Sheridan
No Comments
Rapport Therapeutics Inc. launched with $100 million in series A funding and ambitious plans to bring a hitherto unprecedented level of precision to therapies for neurological disease. Although the Boston-based company is new to the world, its underlying platform has been a decade in the making, and it already has one clinical-stage asset, which is in development for seizure disorders. It is currently undergoing a phase I trial.
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DNA NGS genome sequencing
Newco news

‘Biology no one else will have seen;’ startup Relation seeks new genetic targets

March 6, 2023
By Nuala Moran
No Comments
Newco Relation Therapeutics Ltd. is showing its colors after raising $25 million in a seed round to work on integrating single cell transcriptomics, functional genomics and machine learning – and cut through previously undecipherable combinatorial space – to find and validate drug targets in the non-coding genome.
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DNA in drug capsules
Newco news

New era in genetic medicines beckons as Aera arrives on scene

Feb. 28, 2023
By Caroline Richards
No Comments
Armed with $193 million in combined series A and B rounds, Aera Therapeutics aims to address current challenges with delivering gene-based therapies via a self-assembling human-derived protein platform it has in-licensed from a well-known Harvard scientist’s lab.
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Maximilien Levesque, co-founder and CEO, Aqemia
Newco news

Aqemia making waves in computational drug discovery

Feb. 27, 2023
By Cormac Sheridan
No Comments
For Aqemia SA, the year got off to a good start, as one of its pharma partners, Les Laboratoires Servier SAS, extended an existing collaboration to drug a supposedly undruggable immuno-oncology target, using its Launchpad artificial intelligence platform.
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Brain activity concept illustration
Newco news

Transcend raises $40M to develop methylone-based therapies

Feb. 24, 2023
By Lee Landenberger
No Comments
Transcend Therapeutics Inc. has closed on a series A funding of $40 million for its next-generation compound, methylone, an MDMA analogue, to be developed as a rapid-acting, disease-modifying, non-hallucinogenic treatment for neuropsychiatric conditions, including post-traumatic stress disorder.
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