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BioWorld - Tuesday, May 24, 2022
Home » Authors » Brian Orelli

Brian Orelli

Articles

ARTICLES

FDA icons

Class effect is all JAKed up as applications remain pending at FDA

Aug. 31, 2021
By Brian Orelli
No Comments
Pfizer Inc. reported on Aug. 30, 2021, that its JAK inhibitor, abrocitinib, beat Dupixent (dupilumab, Regeneron Pharmaceuticals Inc./Sanofi SA) in a head-to-head study of patients with moderate to severe atopic dermatitis. In the JADE DARE study, a higher percentage of patients taking abrocitinib had a 4-point improvement in the severity of Peak Pruritus Numerical Rating Scale (PP-NRS4) from baseline to week two compared to Dupixent.
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Down 51%, a gray day for Graybug Vision on mixed AMD data

March 9, 2021
By Brian Orelli
No Comments
Graybug Vision Inc. reported results from the phase IIb Altissimo study testing GB-102 as a treatment for wet age-related macular degeneration (AMD) that didn't live up to expectations set by the phase I/IIa Adagio study.
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Connecting puzzle pieces
Global Life Sciences Partnering Conference

Pharmas dish out advice to biotechs

March 2, 2021
By Brian Orelli
No Comments
During a panel discussion at Biocom California's Global Life Sciences Partnering Conference, business development executives at various pharmaceutical companies advised biotech companies on everything from funding to manufacturing to deal structure.
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Bertrand Ducrey, CEO, Debiopharm

Debiopharm sends IAP inhibitor xevinapant to Merck in a $1B+ deal

March 1, 2021
By Brian Orelli
No Comments
Debiopharm International SA is more interested in developing drugs than marketing them. Bertrand Ducrey, CEO of Debiopharm, said he envisions the drugs the company is stewarding through development as a "living pipeline" that needs to be refreshed as drugs get to late-stage development. So Debiopharm is shipping global rights to xevinapant (Debio-1143) and its follow-on inhibitor of apoptosis proteins antagonist, Debio-4028,  to Merck KGaA, of Darmstadt, Germany.
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Hands holding gears

The backstory behind Gilead and Arcus' 10-year cancer pact

Feb. 24, 2021
By Brian Orelli
No Comments
Gilead Sciences Inc. was looking to get into oncology in a big way. Arcus Biosciences Inc. had a pipeline of cancer drugs it didn't want to break up. While a little unusual, the landmark 10-year pact the companies made last year just made sense, company executives explained during a session at Biocom California's Global Life Science Partnering Conference.
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Optogenetics illustration

Beyond Luxturna companies vie to become the next ocular gene therapy

Feb. 22, 2021
By Brian Orelli
No Comments
The 2017 FDA approval of Luxturna (voretigene neparvovec-rzyl, Roche Holding AG) spurred a race to create the next gene therapy for the eye. The organ is very amenable to gene therapy given that it's a confined space with post-mitotic cells that has immune privilege and requires substantially smaller amounts of viral vector compared to systemic treatments.
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Sore throat illustration

For head and neck cancer, it's all about making Keytruda better

Feb. 2, 2021
By Brian Orelli
No Comments
With the FDA approval of Keytruda (pembrolizumab, Merck & Co. Inc.) in the front-line setting of metastatic or unresectable, recurrent head and neck cancer squamous cell carcinoma, the space has become a race to develop drugs using a variety of mechanisms of action to improve the efficacy of the anti-PD-1 monoclonal antibody.
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Lung cancer illustration

World Conference on Lung Cancer set to fuel targeted drug faceoffs

Jan. 25, 2021
By Brian Orelli
No Comments
The 2020 World Conference on Lung Cancer, which was scheduled to take place in Singapore last August, is set to kick off virtually later this week. The postponement gave companies time to generate additional data as they battle to treat patients with their targeted therapies.
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Drug pricing illustration

Pandemic puts pressure on drug sales

Jan. 19, 2021
By Brian Orelli
No Comments
The 39th Annual J.P. Morgan Healthcare Conference was sans Celgene Corp.'s annual tradition of kicking off the conference with preliminary revenue and earnings from the previous year, but plenty of other companies stepped up and offered preliminary results of their own. Unfortunately, some companies continued to face headwinds selling drugs during the pandemic as patients avoided their doctors' offices.
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DNA, dollars illustration

Gene therapy surges as risks reduced

Dec. 21, 2020
By Brian Orelli
No Comments
Money is flowing into gene therapy as investors have started looking favorably on the risk-reward prospects of the space. "I believe the risk has really substantially decreased as regulatory path has become clearer. There are more projects with lower risk," said Sarah Bhagat, a partner at Sofinnova Investments.
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