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BioWorld - Friday, April 3, 2026
Home » Authors » Brian Orelli

Brian Orelli

Articles

ARTICLES

Pills, bottle, scale and-measuring tape
Newco news

Ambrosia slurps up a $100M series B for its oral obesity drug pipeline

April 2, 2026
By Brian Orelli
No Comments
Ambrosia Biosciences Inc., named after the drink of the Greek gods, secured a $100 million series B to advance its preclinical pipeline of oral obesity drugs. The startup formed after Pfizer Inc. shuttered its Boulder, Colo.-based research facility that the pharma gained through its 2019 acquisition of Array Biopharma Inc.
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Hand holding dollar sign
Respiratory

Pinnacle raises an $89M series B for its oral peptide programs

March 27, 2026
By Brian Orelli
No Comments
Pinnacle Medicines Inc. secured $89 million in a series B financing, bringing the total raised by the company to $134 million. The round was co-led by LAV and Foresite Capital.
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Hand holding dollar sign

Pinnacle raises an $89M series B for its oral peptide programs

March 26, 2026
By Brian Orelli
No Comments
Pinnacle Medicines Inc. secured $89 million in a series B financing, bringing the total raised by the company to $134 million. The round was co-led by LAV and Foresite Capital.
Read More
Illustration of a computer chip with a brain on it
Drug design, drug delivery & technologies

PerturbAI emerges from stealth with an atlas full of data

March 25, 2026
By Brian Orelli
No Comments
PerturbAI has emerged from stealth mode with the release of the world’s largest in vivo CRISPR atlas as described in a preprint on Biorxiv. The study profiled over 7.7 million cells from the brains of 74 mice with different cellular knockouts of 1,947 disease-associated genes. The San Francisco-based company’s Perturb-seq platform combines CRISPR perturbations with single nucleus RNA sequencing to look at gene expression.
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Parkinson's disease illustration showing neurons containing alpha-synuclein
Newco news

Oryon emerges with autologous stem cell therapy for Parkinson’s

March 23, 2026
By Brian Orelli
No Comments
Oryon Cell Therapies, named after the Orion constellation used for navigation at night, emerged from stealth mode to announce a new round of funding and to present data from the phase Ib/IIa study of its neuron replacement therapy in patients with Parkinson’s disease at the 20th International Conference on Alzheimer’s and Parkinson’s Diseases.
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Tinted Euro symbol
Immune

Enodia jumps ahead in Sec61 targeting, adds Kezar’s program

March 17, 2026
By Brian Orelli
No Comments
Enodia Therapeutics Inc. was spun out of The Institut Pasteur by Argobio Studio based on the work of Caroline Demangel, co-founder of Enodia and head of the immunobiology and therapy unit at The Institut Pasteur. Demangel’s lab discovered the mechanism of action of mycolactone, a natural Sec61 inhibitor that causes Buruli ulcers.
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Tinted Euro symbol
Newco news

Enodia jumps ahead in Sec61 targeting, adds Kezar’s program

March 16, 2026
By Brian Orelli
No Comments
Enodia Therapeutics Inc. was spun out of The Institut Pasteur by Argobio Studio based on the work of Caroline Demangel, co-founder of Enodia and head of the immunobiology and therapy unit at The Institut Pasteur. Demangel’s lab discovered the mechanism of action of mycolactone, a natural Sec61 inhibitor that causes Buruli ulcers.
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Gold chain link engraved with "partnership"

Biocom 2026: Pharmas give advice on partnering

Feb. 27, 2026
By Brian Orelli
No Comments
At Biocom’s Global Partnering and Investor Conference, representatives from the business development departments at various pharmaceutical companies provided an update on their appetites for deals. The mood was fairly upbeat because, let’s face it, large pharma has become dependent on external development.
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Global currency

Biocom 2026: The state of venture capital investments

Feb. 26, 2026
By Brian Orelli
No Comments
At Biocom’s Global Partnering and Investor Conference, venture capitalists (VCs) on multiple panels offered their thoughts on the state of venture investing and offered advice for startups interested in securing funding. Sentiment for early stage investment was somewhat mixed, but trended negative as VCs acknowledged that it’s a tough environment in which to raise capital.
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Acquisition puzzle

Gilead brings Arcellx fully under the fold for $7.8B

Feb. 23, 2026
By Brian Orelli
No Comments
Gilead Sciences Inc. is acquiring partner Arcellx Inc. at a value of up to $7.8 billion, consisting of $115 per share up front and a potential payment of $5 per share through a contingent value right.
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