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BioWorld - Saturday, April 25, 2026
Home » Authors » Brian Orelli

Brian Orelli

Articles

ARTICLES

Drug R&D concept image.
Newco news

Anaptysbio’s spinout First Tracks hits the slopes

April 24, 2026
By Brian Orelli
No Comments
Anaptysbio Inc. announced in September of 2025 that it planned to separate its drug development business from the royalties it receives on Jemperli (dostarlimab) from GSK plc and imsidolimab from Vanda Pharmaceuticals Inc. Just seven months later, on April 20, 2026, well ahead of its “year-end 2026” goal, First Tracks Biotherapeutics Inc., the drug development arm of the company, started trading as a standalone company on Nasdaq under the ticker symbol TRAX.
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Jeff Jonas, CEO and Al Robichaud, president, head of R&D, Tortugas Neuroscience
Newco news

Tortugas launches with $106M for neurology, neuropsychiatric drugs

April 21, 2026
By Brian Orelli
No Comments
Tortugas Neuroscience Inc. came out of its shell to announce the raising of $106 million between its seed and series A financing rounds. “We like the symbolism of the sea turtle – long-lived, persistent, very determined,” Tortugas CEO Jeff Jonas said of the company’s name.
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Sickle cell illustration

Novo’s Forma acquisition pays off with mitapivat competitor

April 20, 2026
By Brian Orelli
No Comments
Novo Nordisk A/S reported top-line results from the phase III Hibiscus study of its pyruvate kinase-R activator, etavopivat, which was acquired through the 2022 buyout of Forma Therapeutics Holdings Inc. The results set up a potential competition for patients afflicted by sickle cell disease with fellow PKR activator mitapivat from Agios Pharmaceuticals Inc.
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Ulcerative colitis

Spyre’s SPY-001 induces better outcomes in ulcerative colitis

April 13, 2026
By Brian Orelli
No Comments
Spyre Therapeutics Inc. is off to a good start in its goal to create the best combination therapy for inflammatory bowel disease, a group of chronic, relapsing autoimmune conditions of the digestive tract that encompasses Crohn’s disease and ulcerative colitis. The Waltham, Mass.-based company estimates the market for IBD is currently at approximately $25 billion but will jump to around $40 billion in 2030.
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Photo of hands holding a baby

Realta secures another $40M for its hypoxic ischemic encephalopathy treatment

April 10, 2026
By Brian Orelli
No Comments
Realta Life Sciences Inc. raised an additional $40 million in the final tranche of its series A investment, bringing the total the company has raised to more than $150 million through mission-driven investors and a family-office model.
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Dollar sign in light bulb on yellow background
Cancer

Stipple launches with $100M for novel oncology targets

April 7, 2026
By Brian Orelli
No Comments
Stipple Bio Inc. raised $100 million in a series A financing to support progression of the company’s lead drug, STP-100, an antibody-drug conjugate that binds an undisclosed target, and the company’s Pointillist discovery platform. The round was co-led by RA Capital, a16z Bio+Health and Nextech Invest. Existing investors, including Emerson Collective Investments (managed by Yosemite), GV (Google Ventures), Lola Capital Partners, GordonMD Global Investments and others, also participated in the round.
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Dollar sign in light bulb on yellow background

Stipple launches with $100M for novel oncology targets

April 6, 2026
By Brian Orelli
No Comments
Stipple Bio Inc. raised $100 million in a series A financing to support progression of the company’s lead drug, STP-100, an antibody-drug conjugate that binds an undisclosed target, and the company’s Pointillist discovery platform.
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Pills, bottle, scale and-measuring tape
Newco news

Ambrosia slurps up a $100M series B for its oral obesity drug pipeline

April 2, 2026
By Brian Orelli
No Comments
Ambrosia Biosciences Inc., named after the drink of the Greek gods, secured a $100 million series B to advance its preclinical pipeline of oral obesity drugs. The startup formed after Pfizer Inc. shuttered its Boulder, Colo.-based research facility that the pharma gained through its 2019 acquisition of Array Biopharma Inc.
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Hand holding dollar sign
Respiratory

Pinnacle raises an $89M series B for its oral peptide programs

March 27, 2026
By Brian Orelli
No Comments
Pinnacle Medicines Inc. secured $89 million in a series B financing, bringing the total raised by the company to $134 million. The round was co-led by LAV and Foresite Capital.
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Hand holding dollar sign

Pinnacle raises an $89M series B for its oral peptide programs

March 26, 2026
By Brian Orelli
No Comments
Pinnacle Medicines Inc. secured $89 million in a series B financing, bringing the total raised by the company to $134 million. The round was co-led by LAV and Foresite Capital.
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View All Articles by Brian Orelli

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