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BioWorld - Saturday, March 21, 2026
Home » Authors » Brian Orelli

Brian Orelli

Articles

ARTICLES

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Immune

Enodia jumps ahead in Sec61 targeting, adds Kezar’s program

March 17, 2026
By Brian Orelli
No Comments
Enodia Therapeutics Inc. was spun out of The Institut Pasteur by Argobio Studio based on the work of Caroline Demangel, co-founder of Enodia and head of the immunobiology and therapy unit at The Institut Pasteur. Demangel’s lab discovered the mechanism of action of mycolactone, a natural Sec61 inhibitor that causes Buruli ulcers.
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Tinted Euro symbol
Newco news

Enodia jumps ahead in Sec61 targeting, adds Kezar’s program

March 16, 2026
By Brian Orelli
No Comments
Enodia Therapeutics Inc. was spun out of The Institut Pasteur by Argobio Studio based on the work of Caroline Demangel, co-founder of Enodia and head of the immunobiology and therapy unit at The Institut Pasteur. Demangel’s lab discovered the mechanism of action of mycolactone, a natural Sec61 inhibitor that causes Buruli ulcers.
Read More
Gold chain link engraved with "partnership"

Biocom 2026: Pharmas give advice on partnering

Feb. 27, 2026
By Brian Orelli
No Comments
At Biocom’s Global Partnering and Investor Conference, representatives from the business development departments at various pharmaceutical companies provided an update on their appetites for deals. The mood was fairly upbeat because, let’s face it, large pharma has become dependent on external development.
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Global currency

Biocom 2026: The state of venture capital investments

Feb. 26, 2026
By Brian Orelli
No Comments
At Biocom’s Global Partnering and Investor Conference, venture capitalists (VCs) on multiple panels offered their thoughts on the state of venture investing and offered advice for startups interested in securing funding. Sentiment for early stage investment was somewhat mixed, but trended negative as VCs acknowledged that it’s a tough environment in which to raise capital.
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Acquisition puzzle

Gilead brings Arcellx fully under the fold for $7.8B

Feb. 23, 2026
By Brian Orelli
No Comments
Gilead Sciences Inc. is acquiring partner Arcellx Inc. at a value of up to $7.8 billion, consisting of $115 per share up front and a potential payment of $5 per share through a contingent value right.
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EU flag and microscope

Panelists talk benefits, challenges of European drug development

Jan. 15, 2026
By Brian Orelli
No Comments
At a pair of panels on developing and selling drugs in Europe at the Biotech Showcase 2026 meeting in San Francisco, experts discussed the good, the bad and the ugly parts of the European drug development scene.
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JPM and beyond: Dealmaking forecast for 2026

Jan. 13, 2026
By Brian Orelli
No Comments
At the Biotech Showcase 2026 – part of the broader hoopla in San Francisco surrounding the J.P. Morgan 2026 Healthcare Conference – a panel of investors and another of pharma dealmakers discussed what to expect from drug company deals in 2026. The calendar flipping marks a good time to look ahead, but the delineation doesn’t really change anything for dealmakers who have experienced a slow shift in attitudes of investors over the last few months that will likely continue into the year ahead.
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Businesswoman pressing dollar sign on touchscreen

JPM 2026: Year kicks off with biopharma Q4 revenue and guidance

Jan. 12, 2026
By Brian Orelli
No Comments
It was a battle of the companies with drugs for transthyretin-mediated amyloidosis on the first day of the J.P. Morgan 2026 Healthcare Conference with Alnylam Inc., Bridgebio Pharma Inc. and Pfizer Inc. all presenting at the annual kickoff conference. One company disclosed 2025 sales as well as 2026 revenue guidance, the second only looked back, while the third was too big to do either for a specific drug.
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Eric Shaff, president and CEO, Psithera
Immune

Psithera spun out of Roivant with $47.5M and immune, inflammatory focus

Jan. 5, 2026
By Brian Orelli
No Comments
December 2025 was a big month for announcements from Psithera Inc. The Watertown, Mass.-based newco announced its name change from Psivant Therapeutics, having come out from under the Roivant Sciences Ltd. umbrella – thus the dropping of the “-vant” name. The company also announced a $47.5 million series A financing and disclosed that Eric Shaff had started as the company’s new president and CEO.
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Eric Shaff, president and CEO, Psithera

Psithera spun out of Roivant with $47.5M and immune, inflammatory focus

Jan. 2, 2026
By Brian Orelli
No Comments
December 2025 was a big month for announcements from Psithera Inc. The Watertown, Mass.-based newco announced its name change from Psivant Therapeutics, having come out from under the Roivant Sciences Ltd. umbrella – thus the dropping of the “-vant” name. The company also announced a $47.5 million series A financing and disclosed that Eric Shaff had started as the company’s new president and CEO.
Read More
View All Articles by Brian Orelli

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