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BioWorld - Thursday, June 8, 2023
Home » Topics » Science » Biomarkers

Biomarkers
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Central nervous system
Biomarkers

MYO9B gene mutations tied to CMT2 and optic atrophy, study finds

May 31, 2023
No Comments
Charcot-Marie-Tooth disease (CMT) is a group of neuropathies characterized by sensory and motor dysfunction that progress with aging. It is considered that about 60% of the axonal forms of the disease, such as CMT2, remain genetically undiagnosed.
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Microscopic image of acute myeloid leukemia (AML) cells.
Biomarkers

Low miR-143 expression and high MSI2 expression are associated with poor prognosis in AML

May 19, 2023
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Researchers from Wenzhou Medical University and affiliated organizations have published data from a study that aimed to investigate the relationship between the tumor suppressor microRNA-143 (miR-143) and RNA-binding protein Musashi homolog 2 (MSI2), the abnormal expression of which has been previously associated with cancer progression.
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Gastric cancer
Biomarkers

SDC4 confers poor survival in gastric cancer

May 18, 2023
No Comments
Gastric cancer persists as the fourth leading cause of cancer-related deaths. Syndecans (SDCs) are a family of four transmembrane heparan sulfate proteoglycans involved in cell proliferation, migration and adhesion, among others, and syndecan-4 (SDC4) expression has been shown to be up-regulated during the early stages of the gastric carcinogenesis.
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Heart scientific overlay
Biomarkers

SNP in miR-146a is a prognostic marker in acute coronary syndrome

May 17, 2023
No Comments
Despite advances in diagnosis and treatment, cardiovascular disease remains the leading cause of death worldwide. Single-nucleotide polymorphisms (SNPs) in microRNAs are known to play important roles in acute coronary syndrome (ACS). MicroRNA 146a (miR-146a) is significantly upregulated in human atherosclerotic plaques and its circulating levels are elevated in patients with ACS, and was thus the focus of a recent study.
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Liver anatomy illustration
Biomarkers

Study finds TNFRSF14 and LIGHT levels are elevated in primary sclerosing cholangitis

May 9, 2023
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There is still a lack of specific biomarkers in biliary epithelial cells of patients with primary sclerosing cholangitis (PSC). Investigators from the...
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Closeup of red eye
Biomarkers

Tear cytokine composition useful to diagnose dry eye disease, researchers find

May 8, 2023
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A study comprising a total of 406 subjects, including both healthy individuals (n=54) and patients with dry eye (DE) disease was performed with the aim of discovering basal tear cytokine markers for disease diagnosis and severity. Based on guidelines, patients with DE were classified as predisposed DE (pDE, n=136), mild-moderate DE (mDE, n=185), and severe DE (sDE, n=31).
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Biomarkers

CD138 serum levels are lower in patients with EoE

May 8, 2023
No Comments
Esophageal remodeling occurs during the development of eosinophilic esophagitis (EoE); syndecan-1, also known as CD138, is a cell surface marker involved in extracellular remodeling and it has been shown to be differentially expressed in tissue from patients with EoE compared to healthy esophageal tissue. University of North Carolina at Chapel Hill researchers conducted studies to validate serum CD138 levels as a noninvasive tool for the diagnosis of EoE.
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Eye, DNA double helix illustration.
Biomarkers

New missense mutation in SLC6A6 associated with Leber congenital amaurosis pathology

May 5, 2023
No Comments
The SLC6A6 gene encodes the transporter of the amino acid taurine. In recently presented work, researchers from the Institute of Molecular and Clinical Ophthalmology Basel, University of Basel and affiliated organizations aimed to investigate the molecular pathology of a novel mutation in SLC6A6 and its association with a syndromic form of Leber congenital amaurosis (LCA).
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Illustration of ophthalmoscopic view of diabetic retinopathy.
Biomarkers

Increased ACAT1 expression associated with neurovascular damage in diabetic retinopathy

May 4, 2023
No Comments
Researchers from Augusta University recently presented data from a study that aimed to assess the role of acetyl-CoA acetyltransferase (ACAT1) in neurovascular damage during diabetic retinopathy (DR).
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Biomarkers

Protein RD3 may have prognostic use in neuroblastoma, study finds

April 24, 2023
No Comments
Neuroblastoma is among the deadliest cancers in infants, with frequent relapse and long-term survival being <10%. Recently, it has been found that protein RD3 is constitutively expressed in healthy adult and fetal tissues beyond the retina, and it follows a gradient expression from high to low levels in ganglioneuroma and neuroblastoma.
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