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BioWorld - Tuesday, May 13, 2025

Science

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Home » Topics » Science
  • Liver illustration purple
    May 12, 2025
    By Anette Breindl

    Liver is also immune organ, influenced by microbiome

    Immunity is not a function most people particularly associate with the liver. But because of its connection to the gut, the liver is exposed to bacterial metabolites as few other organs are. And when either the liver or the gut is not functioning well, it can adversely affect immunity as well. The liver is connected to the gut via both the biliary system and the portal vein. Those two conduits allow metabolites from the gut microbiome to influence what’s going on in the liver. Both liver and gut damage can affect this communication for the worse. And surprisingly, one of the consequences is immune dysfunction.
  • Dna and silhouette
    May 8, 2025
    By Anette Breindl

    Organoids plus gene editing bring insights into pediatric metabolic disease

    “I’m a pediatrician in metabolic diseases, and every day in my clinical work I’m confronted with our lack in effective therapies for our patients.” That was the sobering introduction by Sabine Fuchs in her talk at the 2025 Congress of the European Association for the Study of the Liver in Amsterdam this week. The nature of metabolic diseases makes it difficult to develop treatments for them. “There are over 1,500 diseases known by now, and it is just very difficult to develop therapies for each and every individual rare disease.”
  • Heart dna and ecg
    May 7, 2025
    By Nuala Moran

    Nuevocor draws $45M series B for gene therapy in rare heart disease

    Nuevocor Pte. Ltd. has closed a $45 million series B, enabling it to move lead gene therapy NVC-001 into the clinic in the treatment of an inherited form of cardiomyopathy.
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