CD39, also known as ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1), is a cell surface ectonucleotidase with key roles in modulating inflammation and localized immune regulation. Researchers from the Baker Heart and Diabetes Institute and collaborators recently proposed leveraging mRNA technologies to provide sustained, localized CD39 expression without genomic integration.
To overcome the challenges of current CAR T-cell strategies and enhance their efficacy and specificity for acute myeloid leukemia, researchers at the Sino-American Cancer Foundation and collaborating institutions have developed a nanobody-based CAR T-cell platform directed against C-type lectin-like molecule-1 (CLL-1).
The use of DNA scaffolds could mark a turning point in HIV vaccine design. Scientists at Scripps Research and the Massachusetts Institute of Technology (MIT) have created a new vaccine platform based on DNA origami, a material that the immune system does not recognize as a threat, avoiding unwanted responses.
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