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BioWorld - Thursday, June 8, 2023
Home » Topics » Disease categories and therapies » Immune

Immune
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Immune

Nontoxic corticosteroid INX-200 evaluated for severe autoimmune disease

June 7, 2023
No Comments
Glucocorticoids are very effective immunosuppressive and anti-inflammatory drugs that cause dose-limiting toxicities in brain, liver and bone preventing their use mainly in chronic disorders. Researchers from Immunext Inc. recently reported results from the therapeutic evaluation of the nontoxic glucocorticoid INX-200 with anti-inflammatory efficacy in a once-per-month injection.
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William Cao, founder and CEO, Gracell Biotechnologies

Gracell enters autoimmune space with its dual-targeting CAR T

June 6, 2023
By Tamra Sami
No Comments
Gracell Biotechnologies Inc. is initiating two clinical trials in China in refractory systemic lupus erythematosus for lead candidate GC-012F, a CD19/B-cell maturation antigen dual-targeting CAR T. 
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T cells

Selection waits on efficacy data from trial of Kv1.3 ion channel blocker in atopic dermatitis

June 2, 2023
By Cormac Sheridan
No Comments
The coming months represent a crucial phase in the development of Selection Inc., a U.S.-German firm that is tackling a target in autoimmune disease that has evaded the best efforts of many other drug developers.
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Cancer

Macrophage senescence promotes lung cancer progression

June 2, 2023
By Mar de Miguel
No Comments
With age, senescent cells become detrimental to tissues. Mayo Clinic scientists have observed this phenomenon in the lung alveoli, where senescent macrophages accumulated in aging tissue and in early stages of non-small-cell lung cancer (NSCLC) driven by the Kras oncogene. “We found that the macrophages were present in the earliest stages of the disease. Strategies targeting these cells for elimination or preventing their accumulation would be worthwhile to test in other conditions (assuming we find they occur),” Darren Baker, a Mayo Clinic senescent cell biologist and senior author of the study, told BioWorld.
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3D illustration of Yersinia pestis bacteria
Immune

Polyclonal antibodies from transchromosomic bovines immunized with recombinant vaccine protect mice from the plague

June 1, 2023
No Comments
With the rise of antibiotic resistance, treatment options against Yersinia pestis bacteria that cause pneumonic plague could also become limited. Antibody treatment has been effective in animal models of plague, but no approved human vaccine exists against this fatal disease.
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Bladder of a mouse that was reinfected with E. coli
Genitourinary/Sexual Function

Memory T cells control immunity to urinary reinfection

May 31, 2023
By Mar de Miguel
No Comments
Urinary tract infections (UTIs) are often recurrent. The organism does not always establish an effective line of defense that protects from reinfection. The key lies in two reservoirs of bacteria and how tissue-resident memory T cells (TRMs) trigger the immune response. A recent paper from the Pasteur Institute in France describes how these cells mediate immunity to defeat reinfection.
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Global vaccine.png
Immune

Hilleman Laboratories and A*STAR collaborate to develop circRNA vaccine for Nipah virus

May 30, 2023
No Comments
Hilleman Laboratories Singapore Pte Ltd. and the Agency for Science, Technology and Research (A*STAR) have established a collaboration to explore using novel circular ribonucleic acid (circRNA) technology to develop a Nipah virus vaccine and to validate the technology platform for application for other infectious diseases pathogens.
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3D illustration of mesenchymal stem Cells
Inflammatory

Optimized mesenchymal stem cell therapy exhibits efficacy in preclinical model of pulmonary hemorrhage

May 29, 2023
No Comments
The targeted delivery of optimized stem cells directly into injured tissues has been used to maximize efficacy and minimize systemic exposure. Still, despite hundreds of clinical trials evaluating mesenchymal stem cell (MSC) therapy as a treatment, clinical efficacy remains highly variable. Investigators at Case Western Reserve University have developed an optimized combination of cytokines and growth factors applied to MSCs (HXB-319).
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DNA in test tubes
Immune

Evaxion develops genetic adjuvant technology to boost immune response to viral, bacterial and cancer vaccines

May 26, 2023
No Comments
Evaxion Biotech A/S has unveiled the technology behind its proprietary genetic adjuvant developed to enhance the effectiveness of DNA and mRNA vaccines for infectious diseases and cancer.
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Immune

Kymera Therapeutics prepares and tests TYK2 degradation inducers

May 25, 2023
No Comments
Proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to non-receptor tyrosine-protein kinase TYK2-targeting moiety have been reported in a Kymera Therapeutics Inc. patent as potentially useful for the treatment of neurological, inflammatory and endocrine disorders, autoimmune diseases, transplant rejection, graft-vs.-host disease and cancer.
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