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BioWorld - Saturday, September 23, 2023
Home » Topics » Disease categories and therapies » Immune

Immune
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Coronavirus and DNA
Infection

Severe COVID-19 leaves epigenetic immune system memory

Aug. 22, 2023
By Mar de Miguel
No Comments
A study from Weill Cornell Medicine and The Jackson Laboratory has described the epigenetic mark SARS-CoV-2 left on immune system stem cells in the most severe cases of COVID-19 early in the pandemic, before the development of vaccines. In their work published in Cell on Aug. 18, 2023, the researchers presented a new methodology to analyze the epigenetic changes in monocytes and circulating hematopoietic stem and progenitor cells (HSPCs) that give rise to monocytes. That allowed corresponding author Steven Josefowicz and his colleagues to see if there were already changes induced by COVID-19 before HSPCs differentiated into monocytes.
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FDA Approved stamp

Regeneron’s ultra-rare disease drug for Chaple disease is approved by the FDA

Aug. 18, 2023
By Lee Landenberger
The U.S. FDA has approved its second treatment for an ultra-rare disease in the past three days by greenlighting Veopoz (pozelimab-bbfg) from Regeneron Pharmaceuticals Inc. Approval of the priority BLA for Veopoz, a fully human monoclonal antibody to treat Chaple disease, was announced two days ahead of its Aug. 20 PDUFA date. It is the only FDA-approved therapy for the indication.
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Human natural killer cell
Immune

FDA clears IND for Artiva's NK cell therapy candidate Allonk to be studied with rituximab for SLE

Aug. 17, 2023
No Comments
Artiva Biotherapeutics Inc. has received FDA clearance of its IND application for Allonk (AB-101), to be used in combination with rituximab for treatment of systemic lupus erythematosus (SLE) in patients with active lupus nephritis.
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Illustration of cytokine storm (IL-6, IL-8, IL-4, TNF, g-CSF), macrophage and T cell.
Cancer

Preclinical data on the first small-molecule inhibitor of IL-4 presented

Aug. 17, 2023
No Comments
Interleukin-4 (IL-4) plays an important role in regulating inflammation. While several antibody-based options targeting IL-4 have been reported, strategies based on small molecule inhibitors have proven difficult to find.
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3D rendering of CAR T therapy in cell
Immune

Immpact's bispecific CAR T therapy IMPT-514 cleared by FDA to enter clinic for SLE

Aug. 16, 2023
No Comments
Immpact Bio USA Inc. has received FDA clearance of its IND application for IMPT-514, a bispecific CD19/CD20 chimeric antigen receptor (CAR) T therapy for the treatment of active, refractory systemic lupus erythematosus (SLE).
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T cells
Immune

BMS-502, a novel dual DGK α and ζ inhibitor with promising immunostimulant activity

Aug. 11, 2023
No Comments
Researchers from Bristol Myers Squibb Co. presented the discovery and preclinical evaluation of a novel diacylglycerol kinases (DGK) α and ζ dual inhibitors.
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Drug R&D concept image.
Immune

City of Hope receives CIRM funding to support cell and gene therapy clinical trials

Aug. 10, 2023
No Comments
Researchers at City of Hope were awarded $32.3 million from the California Institute for Regenerative Medicine (CIRM) to support three novel phase I clinical trials evaluating innovative cell and gene therapy treatments for patients with HIV, acute myeloid leukemia (AML) and severe aplastic anemia.
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Close-up photo of multi-colored beads threaded onto a string
Immune

Double-double-duty EBV vaccine shows promise in animal models

Aug. 9, 2023
By Anette Breindl
No Comments
An experimental vaccine that contained antigens of both lytic and latent phases of Epstein-Barr virus (EBV), and induced both an antibody and a T cells response, was able to generate broad and long-lasting immunity against EBV in mouse models of infection. Researchers from the QIMR Berghofer Medical Research Institute and Elicio Therapeutics Inc. reported those results online in Nature Communications on Aug. 8, 2023.

For some viruses, the challenge to developing a vaccine is their rapid mutation rate. This is the major challenge to developing an HIV vaccine or a universal flu vaccine. EBV is different. Its superpower is its ability to hide.
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Stem cells

Mesoblast’s hopes dashed again with second FDA complete response letter for remestemcel-L

Aug. 8, 2023
By Tamra Sami
No Comments
Regenerative medicine company Mesoblast Ltd.’s stock sank nearly 57% on the news that it received a second U.S. FDA complete response letter (CRL) following the resubmission of its BLA for allogeneic stem cell treatment remestemcel-L in children with steroid-refractory acute graft-vs.-host disease. In the CRL, issued a few days after the Aug. 2 PDUFA date, the agency said it requires more data to support approval.
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Cross section illustration of HIV virus parts
HIV/AIDS

Human cells have molecular weapon against HIV

Aug. 8, 2023
By Mar de Miguel
No Comments
It has gone unnoticed in HIV research until now, but a transcriptomic analysis has detected a molecule that could kill this virus. Scientists at a U.S. military research institute laboratory have found a common factor in human cells that inhibited the replication of HIV-1 in people living with the virus. “Without any manipulation of cells in people with HIV, we have found a host factor that is inhibiting HIV in vivo,” the senior author Rasmi Thomas, chief of the Laboratory of Integrative Multiomics at Walter Reed Army Institute of Research, told BioWorld. Using single cell RNA sequencing (scRNA-seq), the study published on Aug. 2, 2023, in Science Translational Medicine identified this host factor as prothymosin α, a protein isolated from the thymus in 1966 and described in 1984.
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