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BioWorld - Sunday, July 19, 2026
Home » Topics » Clinical

Clinical
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Lungs

Open-label extension drives home benefits of Insmed’s PAH therapy

July 17, 2026
By Nuala Moran
No Comments
Insmed Inc. has delivered further evidence of the advantages of its once-daily pulmonary arterial hypertension (PAH) drug TPIP (treprostinil palmitil inhalation powder), with data from an open-label extension of the phase IIb trial showing patients in the treated arm maintained the benefits over 24 months.
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Man coughing into hand

Can’t hack it? Bellus tolls for GSK phase III cough drug

July 17, 2026
By Randy Osborne
No Comments
GSK plc’s walk-away from refractory chronic cough prospect camlipixant because of dicey phase III results opened the door wider for Trevi Therapeutics Inc. with Haduvio (oral nalbuphine ER), which yielded positive phase II data in June. Shares of Trevi (NASDAQ:TRVI) closed July 17 at $19.07, up $1.71, or 9.9%. London-based GSK reported findings with camlipixant, a P2X3 receptor antagonist, from the Calm-1 and Calm-2 trials. The first met its primary endpoint, with camlipixant 50 mg twice daily showing statistically significant reductions in 24-hour cough frequency vs. placebo when measured at week 12.
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Targets with arrows

Samsung Bioepis’ Keytruda biosimilar hits phase I, III endpoints

July 15, 2026
By Marian (YoonJee) Chu
No Comments
Samsung Bioepis Co. Ltd. announced positive top-line phase I and phase III data for SB-27, a proposed biosimilar to Merck & Co. Inc.’s blockbuster immunotherapy Keytruda (pembrolizumab). Preliminary analysis of parallel-run global phase I and phase III studies demonstrated SB-27’s clinical and pharmacokinetic (PK) equivalence to the reference product, according to a company announcement.
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Ebola virus

Island Pharma targets Ebola species lacking approved treatments

July 14, 2026
By Tamra Sami
No Comments
Island Pharmaceuticals Ltd. has secured government and ethics approvals to deploy its investigational antiviral galidesivir in patients infected during the escalating Bundibugyo Ebola outbreak in Africa, giving the small Australian biotech a rare opportunity to collect prospective human data in an active filovirus emergency.
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Antibodies and red blood cells

Takeda's mezagitamab adds quality-of-life gains to ITP responses

July 14, 2026
By Tamra Sami
No Comments
Takeda Pharmaceutical Co. Ltd.’s anti-CD38 antibody mezagitamab (TAK-079) is showing benefits beyond platelet restoration, with new data suggesting the candidate may improve quality of life for patients with chronic immune thrombocytopenia (ITP) and sustain those gains after treatment ends.
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Close-up of a medical syringe

First purpose-designed Ebola Bundibugyo vaccine ready for phase I

July 14, 2026
By Nuala Moran
No Comments
The Oxford Vaccine Group has delivered on its promise, and after starting work in mid-May has completed preclinical testing and is ready to begin a phase I trial of a vaccine against the Bundibugyo Ebola virus that is causing the current serious disease outbreak in the Democratic Republic of Congo.
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Senior medical exam
AAIC 2026

Celia trial: data strong, analysts skeptical

July 14, 2026
By Anette Breindl
Tuesday brought what was arguably the most anticipated presentation of the 2026 Alzheimer’s Association International Conference when Catherine Mummery, head of novel therapeutics at University College London’s Dementia Research Center, presented data from the phase II Celia trial of tau-lowering antisense oligonucleotide diranersen (BIIB-080, Biogen Inc.). Based on both clinical and biomarker data, “Celia establishes a proof of concept,” Mummery said, that reducing tau may slow the progression of Alzheimer’s disease.
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Antibodies and red blood cells

Takeda's mezagitamab adds quality-of-life gains to ITP responses

July 13, 2026
By Tamra Sami
No Comments
Takeda Pharmaceutical Co. Ltd.’s anti-CD38 antibody mezagitamab (TAK-079) is showing benefits beyond platelet restoration, with new data suggesting the candidate may improve quality of life for patients with chronic immune thrombocytopenia (ITP) and sustain those gains after treatment ends.
Read More
Scientist with blood test tubes

UK to launch Alzheimer patient database to speed up trials

July 13, 2026
By Nuala Moran
No Comments
The U.K. is setting up a nationwide registry of people with dementia, who will be pre-screened and consented, to speed up recruitment to clinical trials and collect real-world evidence of effectiveness once therapies are approved.
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Hair loss patches on head

JAKs or better: Q32 ups ante in AA with IL-7 antibody phase II

July 13, 2026
By Randy Osborne
No Comments
The clinically proven promise of an alopecia drug, without the risks of black box-bearing JAK inhibitors yet with powerful efficacy, led shares of Q32 Bio Inc. (NASDAQ:QTTB) to close July 13 at $21.38, up $10.17, or 90.7%.
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