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BioWorld - Thursday, September 28, 2023
Home » Topics » Disease categories and therapies » Immune

Immune
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Blood vessels

Humacyte’s phase II/III tissue graft data prompt talk of a BLA

Sep. 12, 2023
By Lee Landenberger
No Comments
Regenerative tissue developer Humacyte Inc. has posted positive top-line phase II/III results for its Human Acellular Vessel, a tissue-engineered graft consisting entirely of decellularized extracellular matrix, for vascular trauma repair. The data showed higher rates of patency, a measure of the lack of vascular obstruction, when compared to synthetic graft benchmarks.
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Myelin sheath and neurons in the brain
Neurology/Psychiatric

Myelin damaged by multiple sclerosis could be repaired by reducing levels of an enzyme

Sep. 8, 2023
By Mar de Miguel
No Comments
In multiple sclerosis (MS), macrophages and microglia play a dual role that could be used to treat this neurodegenerative disease. These cells promote inflammation that demyelinates neurons but also sweep away the debris of damaged myelin and produce neurotrophic factors that would allow its restoration. According to a group of scientists from the University of Hasselt in Belgium, damage or repair depends on a double switch that combines the action of two enzymes, one that desaturates and another that elongates fatty acids. By reducing the levels of these enzymes, phagocytic cells would replenish the myelin instead of engulfing it.
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Close up of senior man holding wrist of arthritic hand
Musculoskeletal

Novel antibody Ab-IPL-IL-17 limits disease progression in preclinical models of rheumatoid arthritis

Sep. 7, 2023
No Comments
The interleukin-17 (IL-17) family is involved in innate immunity regulation and plays a crucial role in inflammatory and autoimmune disorders by sustaining inflammation during the onset and progression of diseases such as rheumatoid arthritis (RA), psoriasis or inflammatory bowel disease (IBD). Researchers from the University of Naples have reported on a new biological entity, Ab-IPL-IL-17, that displays potent anti-inflammatory activity in preclinical testing.
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Thymus
Immune

The human thymus has multipotent stem cells with the capacity to maintain it

Sep. 7, 2023
By Mar de Miguel
No Comments
It was believed that they did not exist, but they are a reality. Scientists at the Francis Crick Institute in London have discovered stem cells in the thymus for the first time. The last organ to have its role described in humans still has properties that researchers could explore to prevent the decline of the immune system throughout life.
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Global vaccine.png
Infection

CEPI and IVI renew collaboration on vaccines against emerging infectious diseases

Sep. 4, 2023
No Comments
The Coalition for Epidemic Preparedness Innovations (CEPI) and the International Vaccine Institute (IVI) have announced a renewed collaboration to accelerate the development of vaccines against emerging infectious diseases.
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Illustration of nerve cells
Newco news

Rewind preps remyelinating agent for clinical trials

Sep. 1, 2023
By Cormac Sheridan
No Comments
For many multiple sclerosis patients, the approval over the past 30 years of a lengthy list of immunomodulatory therapies has helped to reduce the frequency of relapses and to slow disease progression. However, there has been little parallel progress in the development of remyelination therapies, to tackle the other key pathophysiological dimension of the disease. Patients still have no therapies that can help to repair at least some of the damage that results from flare-ups, and the resulting neuronal loss contributes to further disease progression and disability. Rewind Therapeutics NV, of Leuven, Belgium, is one of a small clutch of firms attempting to tackle this problem.
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Art concept for inflamed human tissue
Immune

Novel anti-IL-17A inhibitor shows similar efficacy to biological therapies in IL-17-driven disorders

Sep. 1, 2023
No Comments
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine involved in the pathogenesis of inflammatory, immune-mediated diseases such as psoriasis, psoriatic arthritis and others.
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Dollar sign droplet above test tube
Musculoskeletal

NIH award supports advancement of BITT’s CD40 antagonist antibody BITT-101 for Sjögren’s syndrome

Sep. 1, 2023
No Comments
Boston Immune Technologies and Therapeutics Inc. (BITT) has been awarded funding by the National Institutes of Health (NIH) to support the preclinical development of BITT-101, its CD40 antagonist antibody for treating Sjögren’s syndrome. The award will help support steps toward an IND filing next year.
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Immune

Roche patent details new STING antagonists

Aug. 31, 2023
No Comments
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have patented imidazole macrocycles acting as stimulator of interferon genes protein (STING; TMEM173) antagonists. They are reported to be useful for the treatment of cancer, autoimmune diseases, inflammatory, neurological, metabolic, cardiovascular and ocular disorders.
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Illustration of antibodies attacking nerve cells
Immune

New IRAK4 degrader for the treatment of autoimmune diseases presented

Aug. 31, 2023
No Comments
Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in innate immunity by acting both as a scaffolding protein and a protein kinase, and its overactivation correlates with several autoimmune disorders.
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