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BioWorld - Thursday, September 28, 2023
Home » Topics » Disease categories and therapies » Infection

Infection
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Infection

Revagenix describes broad-spectrum aminoglycosides for bacterial infection

Sep. 27, 2023
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A Revagenix Inc. patent describes broad-spectrum aminoglycosides reported to be useful for the treatment of bacterial infections.
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Mosquito in a test tube.
Infection

GHIT Fund invests in development projects for malaria and neglected tropical diseases

Sep. 27, 2023
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The Global Health Innovative Technology (GHIT) Fund has announced new investments in the development of a new prophylactic vaccine against malaria, a new anti-malarial drug, and product development projects against neglected tropical diseases.
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Tuberculosis
Infection

An2 Therapeutics receives Gates Foundation grant to discover boron-based therapies for malaria and TB

Sep. 27, 2023
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An2 Therapeutics Inc. has received a research grant from the Bill & Melinda Gates Foundation to discover novel, boron-containing small molecules for the treatment of tuberculosis (TB) and malaria.
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Methicillin-resistant S. aureus (MRSA)
Infection

Novel pleuromutilin analog shows potent antibacterial activity against MRSA

Sep. 27, 2023
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Methicillin-resistant S. aureus (MRSA) causes difficult-to-treat infections due to its inherent resistance. Thus finding new strategies to overcome MRSA resistance is critical. Researchers from China Agricultural University reported on the discovery and optimization of a novel series of pleuromutilin derivatives containing benzoxazole-2-thiol.
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Infection

New nucleoside analogues described in Gilead Sciences patent

Sep. 26, 2023
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Gilead Sciences Inc. researchers have identified new nucleoside analogues reported to be useful for the treatment of viral infection.
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Infection

Targeting TBK1 and IKKε with synthetic flavonoid reduces COVID-19-like immunopathology in a mouse model

Sep. 26, 2023
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TANK-binding kinase 1 (TBK1) serves prominent innate immune functions via complex interactions with adaptor proteins to affect phosphorylation of NF-κB (NF-κB). TBK1 is at the nexus of multiple pathways connecting interferon pathway activation and this is ultimately beneficial or hyperinflammatory-pathological in the context of viral infections.
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Scynexis recalls its antifungal Brexafemme

Sep. 25, 2023
By Lee Landenberger
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Fearing cross contamination might have occurred during manufacturing, Scynexis Inc. is recalling Brexafemme (ibrexafungerp tablets) from the market and putting a temporary hold on the drug’s clinical trials until it knows more details.
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Infection

Westvac Biopharma discovers new Mpro inhibitors for SARS-CoV-2

Sep. 22, 2023
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Westvac Biopharma Co. Ltd. has described keto amide derivatives acting as 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Influenza virus
Infection

Via Nova Therapeutics receives FDA clearance of IND for influenza A nucleoprotein inhibitor

Sep. 22, 2023
No Comments
Via Nova Therapeutics Inc. has received clearance of its IND application from the FDA for its influenza A nucleoprotein inhibitor, VNT-101. The novel investigational small molecule is directed against a novel target, the influenza A nucleoprotein, and is being developed for treatment of seasonal influenza A infection.
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Infection

Versitech and Ningbo Combireg Pharmaceutical patent benzothiazole compounds to treat SARS-CoV-2

Sep. 21, 2023
No Comments
Researchers at Ningbo Combireg Pharmaceutical Technology Co. Ltd. and Versitech Ltd. have described benzothiazole compounds reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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