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Home » Topics » Disease categories and therapies » Infection

Infection
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Infection

Arietis, St. Jude Children’s Research Hospital report dual action antibiotics in patent

March 27, 2025
rietis Corp. and St. Jude Children’s Research Hospital Inc. have jointly patented compounds acting as caseinolytic protease P (ClpP) (bacterial) activators and RNA polymerase (bacterial) inhibitors and their conjugates with rifamycin analogues reported to be useful for the treatment of gram-positive bacterial infection.
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Virus and drug illustration
Infection

Decoy Therapeutics’ antiviral candidates show broad activity against multiple viruses

March 27, 2025
Decoy Therapeutics Inc. has announced that a series of antiviral drug candidates previously designed by its Imp3act platform to be broadly effective against viruses of the paramyxoviridae family have also shown promising in silico activity against measles and Nipah viruses. The candidates were previously shown to be active in vitro against respiratory syncytial virus and human parainfluenza virus 3.
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Infection

AMA1-targeting antibodies provide multi-strain malaria protection

March 26, 2025
Writing in Cell Reports, researchers from the National Institute of Allergy and Infectious Diseases (NIAID) and collaborators have presented a multifaceted analysis and structure-function study of a panel of human monoclonal antibodies (hmAbs) targeting AMA1 elicited by natural Plasmodium falciparum infection in a malaria-endemic region in Mali.
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FDA clears new class of antibiotic with nod for GSK’s Blujepa

March 25, 2025
By Jennifer Boggs
Ushering in a new class of antibiotics, the U.S. FDA approved GSK plc’s gepotidacin for use in uncomplicated urinary tract infections. Branded Blujepa, the oral triazaacenaphthylene bacterial topoisomerase inhibitor is indicated for treating female adults and adolescents, 12 and older.
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IV drips

Taimed’s long-acting HIV treatment offers daily ART alternative

March 25, 2025
By Tamra Sami
Taimed Biologics Inc.’s TMB-365/TMB-380 long-acting combination of broadly neutralizing antibodies regimen for HIV maintenance could reshape HIV treatment management, offering a viable alternative to daily combination antiretroviral therapy (cART), the Taipei-based company said after reporting on phase IIa results.
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Dollar sign in light bulb on yellow background

Report shows increased pharma innovation despite rising R&D costs

March 25, 2025
By Nuala Moran
The obesity market is driving pharma’s return on investment (ROI) upward, with the projected return rising to 5.9% overall in 2024, but only reaching 3.8% if GLP-1 assets are excluded. At the same time, the average cost of developing a drug continues to rise and now stands at $2.23 billion, compared to $2.12 billion in 2023, according to Deloitte’s 15th annual analysis of the ROI from pharmaceutical innovation.
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Closeup of Aedes mosquito on skin.
Infection

New symptomatic, immune-competent neonatal mouse model of dengue virus infection

March 25, 2025
Dengue virus (DENV) is a member of the flavivirus family causing dengue fever, a mosquito-borne disease that can be life-threatening. Despite DENV’s widespread presence in over 80 countries and the significant health burden posed by the infection, there is still a critical need for therapeutics and vaccines, with current treatment options only providing supportive care.
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CDC’s ACIP meeting rescheduled

March 24, 2025
By Karen Carey
A meeting of the CDC’s Advisory Committee on Immunization Practices (ACIP) was rescheduled for April 15-16, according to the Federal Register.
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Closeup of Aedes mosquito on skin.
Infection

New symptomatic, immune-competent neonatal mouse model of dengue virus infection

March 24, 2025
Dengue virus (DENV) is a member of the flavivirus family causing dengue fever, a mosquito-borne disease that can be life-threatening. Despite DENV’s widespread presence in over 80 countries and the significant health burden posed by the infection, there is still a critical need for therapeutics and vaccines, with current treatment options only providing supportive care.
Read More
Infection

Nucleoside prodrugs for viral infections disclosed in Gilead patent

March 21, 2025
Gilead Sciences Inc. has divulged nucleoside prodrugs reported to be useful for the treatment of viral infections.
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