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BioWorld - Monday, December 11, 2023
Home » Topics » Disease categories and therapies » Infection

Infection
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Coronavirus, lungs
Infection

GHRH-R antagonist attenuates pulmonary dysfunction, heart injury in COVID-19 mice

Nov. 27, 2023
No Comments
Based on previous studies that have demonstrated the potential of growth hormone-releasing hormone receptor (GHRH-R) antagonists to modulate immune responses to bleomycin lung injury, researchers from the University of Miami and affiliated organizations aimed to evaluate the potential of the GHRH-R antagonist MIA-602 in a mouse model of rVSV-SARS-CoV-2-induced pulmonary dysfunction and heart injury.
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Leishmania parasites
Infection

Synthesis and evaluation of new quinoline-piperazine/pyrrolidine compounds against leishmaniasis

Nov. 24, 2023
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Central Drug Research Institute investigators have synthesized novel compounds conjugating the quinoline moiety with a piperazine/pyrrolidine scaffold through a molecular hybridization approach and investigated their antileishmanial activity.
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Infection

Zenal Pharmachem divulges new compounds to treat infection

Nov. 23, 2023
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Zenal Pharmachem LLC has synthesized novel aryl azo pyrazole compounds reported to be useful for the treatment of infections.
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3D print imagery of hepatitis B virus
Infection

Discovery of TBA derivatives as potent HBV capsid assembly modulators

Nov. 23, 2023
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Researchers from Weifang Medical University and affiliated organizations have published details on the discovery of novel hepatitis B virus (HBV) capsid assembly modulators (CAMs).
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Infection

Tsinghua University discovers new SARS-CoV PL-pro inhibitors for coronavirus acute respiratory syndrome

Nov. 22, 2023
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Tsinghua University has described non-structural protein 3 (nsp3; PL-pro) (SARS-CoV) inhibitors reported to be useful for the treatment of coronavirus acute respiratory syndrome.
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Influenza virus
Patents

Metal-enhanced fluorescence system quickly detects viral infections

Nov. 21, 2023
By Marian (YoonJee) Chu
No Comments
South Korean researchers from the Gwangju Institute of Science and Technology (GIST) developed a new fluorescence-based lateral-flow immunoassay (LFI) enhanced with gold nanorod (GNR)-based probes to detect viral infections like the influenza A virus.
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Transmission electron micrograph of hepatitis B virus particles
Infection

A-7387 inhibits bile acid transporter and blocks hepatitis infection

Nov. 21, 2023
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Researchers from Ipsen Ltd. and affiliated organizations presented the discovery and preclinical characterization of a novel NTCP inhibitor, A-7387, being developed for the treatment of HBV and HDV infections.
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Cross section illustration of HIV virus parts
HIV/AIDS

Arenaviral therapeutic vaccine HB-500 gets IND clearance for HIV

Nov. 21, 2023
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Hookipa Pharma Inc. has received clearance from the FDA for its IND application for HB-500, a novel arenaviral therapeutic vaccine for the treatment of HIV.
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A C. diff bacterium (green) with iron particles in red
Infection

Organelles protect Clostridioides difficile from iron overdose

Nov. 21, 2023
By Mar de Miguel
No Comments
The bacterium Clostridioides difficile (C. difficile) forms organelles that help them defend against iron in the colon. According to a group of scientists from Vanderbilt University, this pathogen, which causes serious gastrointestinal infections, expresses fez genes to build structures called ferrosomes that store excess iron that is toxic to it. Its ferrosomes are surrounded by membrane and could be a target against this microorganism.
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T cells attacking cancer cells
Cancer

T-Therapeutics raises $59M in series A for T-cell receptors

Nov. 20, 2023
By Nuala Moran
No Comments
Newco T-Therapeutics Ltd. has raised £48 million (US$59 million) in a series A to advance development of T-cell receptors generated by its transgenic mouse platform for the treatment of solid tumors, autoimmune diseases and infections. In cancer, the specificity of T-Therapeutics’ molecules will overcome shortcomings of immuno-oncology drugs such as checkpoint inhibitors that stimulate a response to some cancer neo-antigens but are unable to recognize cancer-specific self-antigens.
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