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BioWorld - Friday, June 20, 2025
Home » Topics » Disease categories and therapies » Infection

Infection
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3d rendering of bispecific antibodies
Infection

Cell-penetrating bispecific HBcAg/pre-S1 antibody suppresses HBV replication and secretion

April 1, 2025
Hepatitis B virus (HBV) infection is associated with liver diseases, including chronic hepatitis, which notably increases the risk of cirrhosis and hepatocellular carcinoma (HCC) development. Although some of the current treatment strategies promote virological suppression, they are insufficient to halt HCC development.
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Global vaccine.png
Immune

Institut Pasteur advances Lassa fever vaccine based on new MOPEVAC platform

April 1, 2025
An Institut Pasteur team has developed an original vaccine platform known as MOPEVAC, that will strengthen the organization’s pandemic preparedness initiatives, with the platform’s first vaccine candidate, which targets Lassa fever, set to enter the clinic.
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Influenza virus
Infection

Combining antibody domain, NA-targeting drug makes for broad-spectrum antibody

April 1, 2025
By Xavier Bofill Bruna
The ability of influenza virus to rapidly undergo antigenic shift to evade immunity raises the need for effective influenza antivirals with a broad spectrum. In a recent Nature Microbiology article, Cidara Therapeutics Inc. provided preclinical data for their drug-Fc conjugate compound CD-388, which has the potential to be a robust therapeutic option for the universal prevention of both seasonal and pandemic influenza.
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Vaccine vials and syringe

Vaxcyte sights set on next results after ‘big moment’ with PCV

March 31, 2025
By Randy Osborne
Vaxcyte Inc. characterized its latest phase II data with VAX-24 as positive but Wall Street wasn’t so sure about the dose-finding outcomes with the 24-valent pneumococcal conjugate vaccine (PCV), and shares of the San Carlos, Calif.-based firm (NASDAQ:PCVX) closed March 31 at $37.76, down $31.70, or 46%.
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Marks’ departure intensifies regulatory uncertainty at US FDA

March 31, 2025
By Mari Serebrov
Peter Marks’ March 28 letter giving one week’s notice of his resignation as director of the U.S. FDA’s Center for Biologics Evaluation and Research (CBER) is sending more ripples of uncertainty throughout the industry. Marks, who has helmed CBER for nearly a decade, blamed his departure on recently confirmed Health and Human Services (HHS) Secretary Robert Kennedy, who has made a career out of his anti-vaccine stance.
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Infection

The University of Hong Kong discloses new antimicrobial compounds

March 28, 2025
The University of Hong Kong has patented RNA polymerase β subunit/RNA polymerase sigma factor RpoD (bacterial) interaction inhibitors reported to be useful for the treatment of gram-positive bacterial infections.
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Infection

Arietis, St. Jude Children’s Research Hospital report dual action antibiotics in patent

March 27, 2025
rietis Corp. and St. Jude Children’s Research Hospital Inc. have jointly patented compounds acting as caseinolytic protease P (ClpP) (bacterial) activators and RNA polymerase (bacterial) inhibitors and their conjugates with rifamycin analogues reported to be useful for the treatment of gram-positive bacterial infection.
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Virus and drug illustration
Infection

Decoy Therapeutics’ antiviral candidates show broad activity against multiple viruses

March 27, 2025
Decoy Therapeutics Inc. has announced that a series of antiviral drug candidates previously designed by its Imp3act platform to be broadly effective against viruses of the paramyxoviridae family have also shown promising in silico activity against measles and Nipah viruses. The candidates were previously shown to be active in vitro against respiratory syncytial virus and human parainfluenza virus 3.
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Infection

AMA1-targeting antibodies provide multi-strain malaria protection

March 26, 2025
Writing in Cell Reports, researchers from the National Institute of Allergy and Infectious Diseases (NIAID) and collaborators have presented a multifaceted analysis and structure-function study of a panel of human monoclonal antibodies (hmAbs) targeting AMA1 elicited by natural Plasmodium falciparum infection in a malaria-endemic region in Mali.
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FDA clears new class of antibiotic with nod for GSK’s Blujepa

March 25, 2025
By Jennifer Boggs
Ushering in a new class of antibiotics, the U.S. FDA approved GSK plc’s gepotidacin for use in uncomplicated urinary tract infections. Branded Blujepa, the oral triazaacenaphthylene bacterial topoisomerase inhibitor is indicated for treating female adults and adolescents, 12 and older.
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