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BioWorld - Sunday, May 22, 2022
Home » Authors » Lee Landenberger

Lee Landenberger

Articles

ARTICLES

Foghorn’s phase I in AML on a partial clinical hold

May 20, 2022
By Lee Landenberger
No Comments
In the wake of a patient’s death, the U.S. FDA has placed a partial clinical hold on Foghorn Therapeutics Inc.’s phase I study of FHD-286 in treating relapsed and/or refractory acute myelogenous leukemia (r/r AML) and myelodysplastic syndrome.
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Respiratory syncytial virus, 3D illustration

Enanta forges on in RSV as phase IIb study fails

May 19, 2022
By Lee Landenberger
No Comments
Respiratory syncytial virus (RSV) continues to be a tough indication. Enanta Pharmaceuticals Inc.’s phase IIb study of otherwise healthy adults treated with EDP-938, an N-protein inhibitor, missed its primary endpoint of reduction in total symptom score compared to placebo. It also missed the study’s secondary antiviral endpoints.
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Global pandemic threat

Too little, too late: WHO panel says the world is vulnerable to another pandemic

May 18, 2022
By Lee Landenberger
No Comments
A year after the World Health Organization's (WHO) Independent Panel for Pandemic Preparedness and Response called for reforms to make COVID-19 the last pandemic, the panel remains solidly frustrated in its lack of progress.
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DNA in drug capsules

Avrobio’s gene therapy prompts positive phase I/II data in cystinosis

May 17, 2022
By Lee Landenberger
No Comments
It was a patient-reported outcome, one that could actually be seen in the mirror, that alerted researchers they might be on track in their phase I/II study of cystinosis. The patient noticed that for the first time in his life his hair had become darker, like his brother’s. It was all because the rare disease inhibiting the pigment in his body was being impacted by the treatment. “It’s a secondary issue, but I find it fascinating,” Avrobio Inc.’s CEO, Geoff MacKay, told BioWorld. “When you run trials like this, you stumble upon some fascinating results.”
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Cancer cells being destroyed by immunotherapy

The trouble with TIGITs: Genentech’s failure sparks worry across class

May 17, 2022
By Lee Landenberger
No Comments
A phase III failure for Roche Holding AG unit Genentech Inc.'s anti-TIGIT immunotherapy tiragolumab dragged down the share value of several other class entrants. 
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Kriya lands $270M series C as it hones gene therapy pipeline

May 16, 2022
By Lee Landenberger
No Comments
Kriya Therapeutics Inc. has raised a $270 million series C financing to further develop its pipeline of gene therapies for treating cancer, ophthalmological problems, and rare and chronic diseases. The Redwood City, Calif.-based company has greatly expanded its employee roster, from about seven people to around 160 people, since its $80 million series A in May 2020 and scaled its learning-enabled tech and cloud computing abilities. It also further solidified its technology, manufacturing, R&D, and therapeutics units, something it plans to continue with the series C money.
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FDA Approved stamp

Lilly’s Mounjaro first to win US FDA approval for GLP-1 and GIP dual agonist

May 13, 2022
By Lee Landenberger
No Comments
Six weeks ahead of its June 26 PDUFA date, the U.S. FDA has approved a priority NDA for Eli Lilly and Co.’s Mounjaro (tirzepatide), an injectable treatment for adults with type 2 diabetes (T2D). The once-weekly, first-in-class medicine activates both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, which leads to improved blood sugar control. The potential market is massive, as 462 million people across the planet have T2D. The numbers have been growing 1.4% annually as the population ages and grows more obese.
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Handshake

Bridgebio bolsters itself with a $1.8B BMS deal

May 12, 2022
By Lee Landenberger
No Comments
Bridgebio Pharma Inc. is going back to the Bristol Myers Squibb Co. (BMS) well to restore its stalled momentum as the two companies have supercharged their July 2021 collaboration to develop an SHP2 inhibitor. Bridgebio could receive up to $905 million, including an up-front payment of $90 million plus $815 million in milestone and royalty payments, expected to be in the low- to midteens, in its new BMS collaboration to develop and commercialize BBP-398 in oncology.
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Cancer cells being destroyed by immunotherapy

The trouble with TIGITs: Genentech’s failure sparks worry across class

May 11, 2022
By Lee Landenberger
No Comments
A phase III failure for Roche Holding AG unit Genentech Inc.'s anti-TIGIT immunotherapy tiragolumab dragged down the share value of several other class entrants. 
Read More
IPO money

Pepgen and B&L join a struggling IPO market

May 10, 2022
By Lee Landenberger
No Comments
IPOs continue to be sluggish but two companies, Pepgen Inc. and Bausch & Lomb Corp., that began trading May 6 managed to sidestep the turbulence despite having to lower their expectations before the market opened.
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View All Articles by Lee Landenberger

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