John Fox

Sepsis study may yield new treatment strategies

April 7, 2020

Indian scientists have discovered a previously unknown mechanism underlying life-threatening sepsis and proposed a new treatment strategy centered upon cell-free chromatin (cfCh), they reported in the March 4, 2020, edition of PLOS ONE.

Sepsis study may yield new treatment strategies

April 2, 2020

By John Fox

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Indian scientists have discovered a previously unknown mechanism underlying life-threatening sepsis and proposed a new treatment strategy centered upon cell-free chromatin (cfCh), they reported in the March 4, 2020, edition of PLOS ONE. Notably, they showed that sepsis could be caused by cfCh released from dying host cells following microbial infection.

Sepsis study may yield new treatment strategies

April 1, 2020

By John Fox

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Indian scientists have discovered a previously unknown mechanism underlying life-threatening sepsis and proposed a new treatment strategy centered upon cell-free chromatin (cfCh), they reported in the March 4, 2020, edition of PLOS ONE. Notably, they showed that sepsis could be caused by cfCh released from dying host cells following microbial infection.

Targeting glycosylated PD-1 induces potent antitumor immunity

March 24, 2020

By John Fox

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Targeting glycosylated PD-1 immune checkpoint may be a promising new cancer immunotherapeutic strategy, according to a collaborative study led by Taiwanese researchers, which was reported online in Cancer Research.

Targeting glycosylated PD-1 induces potent antitumor immunity

March 20, 2020

By John Fox

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Targeting glycosylated PD-1 immune checkpoint may be a promising new cancer immunotherapeutic strategy, according to a collaborative study led by Taiwanese researchers, which was reported online in the March 10, 2020, edition of Cancer Research.

Feisty old folks

Sprightly genomes bring insights into healthy aging, early-onset illness

January 28, 2020

By John Fox

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Australian researchers led by the Garvan Institute of Medical Research in Sydney have compiled the first reference genome database of healthy older Australians, which potentially can predict disease-linked gene variants more accurately than has been previously possible.

Bringing glaucoma risk into focus

Multitrait analysis predicts glaucoma susceptibility, progression

January 28, 2020

By John Fox

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An international collaborative study led by geneticists at the Queensland Institute of Medical Research Berghofer Medical Research Institute (QIMR) in Brisbane, Australia, has used a multivariate approach to develop a polygenic risk score (PRS) for glaucoma.

Bringing glaucoma risk into focus

Multitrait analysis predicts glaucoma susceptibility, progression

January 24, 2020

By John Fox

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An international collaborative study led by geneticists at the Queensland Institute of Medical Research Berghofer Medical Research Institute (QIMR) in Brisbane, Australia, has used a multivariate approach to develop a polygenic risk score (PRS) for glaucoma.

Another role for HIF-2a

Glutamine transporter variant identified as new cancer target

January 7, 2020

By John Fox

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A mitochondrial glutamine transporter variant is a key regulator of glutamine metabolism and metabolic reprogramming in cancer cells, and targeting such transporters could be a new strategy for controlling tumor growth.

Pick your poison

Cobra genome may yield new antivenoms, venom-based drugs

January 7, 2020

By John Fox

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A reference genome from the Indian cobra compiled in an international collaborative study should lead to the development of new safer and more effective antivenoms, while the elucidated genome and predicted associated proteome may be a powerful platform for studies of venomous snakes.