An international study led by scientists at Duke-NUS Medical School in Singapore has identified signaling for the cytokine IL-11 as representing a potential new therapeutic target for acetaminophen-induced liver injury in mouse models.
An international study led by virologists at The University of Hong Kong has shown that geographically and genetically distinct Middle East respiratory syndrome coronaviruses (MERS-CoV) from Africa have lower replication competence in human and mouse lung than those from the ME.
The new peroxisome proliferator-activated receptor gamma (PPARgamma) agonist leriglitazone (hydroxypioglizatone; Minoryx Therapeutics), has a better profile for treating neurodegenerative diseases, such as X-linked adrenoleukodystrophy (X-ALD), than similar drugs, including pioglitazone (Actos; Takeda).
Single-cell gene studies at Duke-NUS Medical School in Singapore and Monash University in Melbourne, Australia, have shown that gene expression signatures underlie the microglial phagocytosis of beta-amyloid (Abeta) plaque in patients with Alzheimer's disease (AD), the authors reported in the May 20, 2021, edition of Nature Communications.
A Japanese study led by researchers at Osaka University has discovered a previously unknown molecular mechanism by which the hepatitis C virus (HCV) interacts with the human immune system to cause chronic liver infection.
Japanese scientists led by Shin Kaneko, an associate professor in the Center for iPS Cell Research and Application at Kyoto University, have developed the first practical bioengineering strategy for generating a universal pluripotent stem cell.
A Chinese study led by scientists at Zhejiang University in Hangzhou City has identified a linker of resistance from the mobile colistin resistance gene 3, which might represent a promising drug target against which to develop small-molecule inhibitors to reverse colistin resistance.
British and Taiwanese scientists have described a novel approach to the treatment of autoimmune rheumatoid arthritis, using an already approved DNA-methylation inhibitor, which was shown to effectively treat active inflammatory disease in animal models.