Single-cell gene studies at Duke-NUS Medical School in Singapore and Monash University in Melbourne, Australia, have shown that gene expression signatures underlie the microglial phagocytosis of beta-amyloid (Abeta) plaque in patients with Alzheimer's disease (AD), the authors reported in the May 20, 2021, edition of Nature Communications.
A Japanese study led by researchers at Osaka University has discovered a previously unknown molecular mechanism by which the hepatitis C virus (HCV) interacts with the human immune system to cause chronic liver infection.
Japanese scientists led by Shin Kaneko, an associate professor in the Center for iPS Cell Research and Application at Kyoto University, have developed the first practical bioengineering strategy for generating a universal pluripotent stem cell.
A Chinese study led by scientists at Zhejiang University in Hangzhou City has identified a linker of resistance from the mobile colistin resistance gene 3, which might represent a promising drug target against which to develop small-molecule inhibitors to reverse colistin resistance.
British and Taiwanese scientists have described a novel approach to the treatment of autoimmune rheumatoid arthritis, using an already approved DNA-methylation inhibitor, which was shown to effectively treat active inflammatory disease in animal models.
A Japanese study has found that the Helicobacter pylori oncoprotein, CagA, elicited transient 'BRCAness', inducing genomic instability via DNA double-strand breaks and defective homologous recombination. The effects may underlie the gastric carcinogenesis associated with chronic H. pylori infection.
An international collaborative study led by scientists at Sweden’s Lund University has classified Alzheimer’s disease into four distinct subtypes, which has important implications for the management of the progressive neurodegenerative disease, the authors reported in the April 29, 2021, edition of Nature Medicine.
A Korean/U.S. collaborative study has shown that increased circulating mitochondrial N-formyl peptide contributes to development of secondary hospital-acquired (nosocomial) infections and increased mortality in septic shock patients who survived the early hyperinflammatory phase.
Under certain circumstances, a normally innocuous key molecular intermediate of regular cell metabolism, farnesyl pyrophosphate, can trigger neuronal lysis and cell death, according to a study led by Chinese researchers at Tsinghua and Peking universities in Beijing.
A collaboration aimed at identifying and developing potential new antimalarial drug candidate drugs has been announced between Walter and Eliza Hall Institute for Medical Research in Melbourne, Australia, and Janssen Pharmaceutica, with assistance from Johnson & Johnson Innovation.
