The French Cosegregation Variant study, a collaboration by cancer genetics clinics and laboratories led by geneticists at the Curie Institute in Paris, has demonstrated that cosegregation analysis represents a powerful tool for classifying variants in BRCA1 and BRCA2 breast-ovarian cancer predisposition genes.
An international collaborative study has identified several novel derivatives of anticancer proteasome inhibitors (PIs) that had potential as antimalarials, the authors reported in the September 28, 2021, online edition of Proceedings of the National Academy of Sciences.
A multicenter study led by scientists at Monash Institute of Pharmaceutical Sciences in Melbourne, Australia, has described a new mesenteric lymph vessel-based pathogenic mechanism, which was shown to contribute to visceral fat accumulation and insulin resistance in both mice and humans.
A comprehensive nontargeted metabolomics analysis has revealed previously unknown classes of disease-linked metabolites in whole blood samples from dementia patients, which may have significant therapeutic implications for managing the untreatable common cognitive disorder.
A comprehensive nontargeted metabolomics analysis has revealed previously unknown classes of disease-linked metabolites in whole blood samples from dementia patients, which may have significant therapeutic implications for managing the untreatable common cognitive disorder.
A comprehensive nontargeted metabolomics analysis has revealed previously unknown classes of disease-linked metabolites in whole blood samples from dementia patients, which may have significant therapeutic implications for managing the untreatable common cognitive disorder.
The most comprehensive international collaborative analysis to date of the impact of variants on gene expression has revealed thousands of previously unknown regulatory genomic regions controlling disease-linked genes, representing a major advance in genomics-driven precision medicine.
A new Drosophila melanogaster larval model recapitulates key aspects of tumor-induced cachexia, including muscle wasting, loss of tissue integrity and lipid mobilization, the authors of a multicenter Australian study reported in the September 1, 2021, online edition of Developmental Cell.
A study led by researchers at Tsinghua University in Beijing has elicited the mechanism whereby the protein leucine-rich repeat kinase 2 prevents alveolar type II epithelial cell dysfunction, limiting profibrotic responses during progression of pulmonary fibrosis.
A whole genome sequencing study has been the first to demonstrate a strong association between infection with the avian influenza A virus H7N9 and rare, heterozygous single-nucleotide variants in the MX1 gene encoding for the myxovirus resistance protein A.
