Immunotherapeutic targeting of stage-specific embryonic antigen-4 has been shown to inhibit pancreatic cancer growth in animal models and cancer cell lines, indicating that this approach has promise for treating pancreatic ductal adenocarcinoma and possibly other SSEA-4-positive cancers, according to new a Taiwan/U.S. collaborative study.
Australian researchers have developed a new single-cell expressed barcoding strategy termed SPLINTR (Single-cell Profiling and LINeage TRacing), to investigate the key basic nongenetic transcriptional processes underlying malignant clonal fitness in mouse models of leukemia.
Stimulating the innate immune system with defective viral genomes (DVG)-based strategy provided broad-spectrum protection against RNA viral infections, including SARS-CoV-2 and other respiratory diseases in animal models, according to a U.S.-led international collaborative study reported in the Nov. 17, 2021, edition of Cell.
Targeting the epigenetic histone modifier BMI-1 in B cells restored effective humoral immune responses to control chronic viral infection in mice, according to new multicenter Australian study led by immunologists at Monash University in Melbourne, Victoria.
Investigators have identified a previously unrecognized population of senescent cells, called p21high cells, in fat tissue and demonstrated their contributory role in metabolic dysfunction, obesity, insulin resistance and type 2 diabetes.
A newly developed antibody-based treatment and a protein-based vaccine for Alzheimer's disease (AD) have both been shown to reduce AD symptoms in mouse models of the disease, British and German researchers reported in the November 15, 2021, edition of Molecular Psychiatry.
Immune system B cells secrete the neurotransmitter gamma amino-butyric acid (GABA), which promotes generation of anti-inflammatory macrophages and blunts the cytotoxic T cell-based response to tumors in mice.
Immune system B cells secrete the neurotransmitter gamma amino-butyric acid (GABA), which promotes generation of anti-inflammatory macrophages and blunts the cytotoxic T cell-based response to tumors in mice.
A study led by scientists at Victor Chang Cardiac Research Institute in Sydney, Australia, has shown that the transcription factor hypoxia-inducible factor 1 (HIF-1) suppresses harmful reactive oxygen species (ROS)-induced growth of cardiac fibroblasts (CFs) and fibrotic scarring after myocardial infarction (MI) in knockout (KO) mice.
A newly developed messenger RNA vaccine is the first such approach to elicit acquired resistance against the tick Ixodes scapularis and prevent it from transmitting the Lyme disease vector Borrelia burgdorferi in guinea pigs, according to a U.S. study led by researchers at Yale University School of Medicine in New Haven, Conn.
