A Chinese study led by scientists at Nanjing University is the first to show that modified small extracellular vesicles can cross the placenta and blood-brain barrier to target drug delivery in mice infected with the Zika virus, in which they were shown to significantly reduce fetal neurological damage, including microcephaly.
An international study led by U.S. oncologists at Children's Hospital of Philadelphia has successfully used a new antibody discovery platform developed by Myrio Therapeutics of Melbourne, Australia, to help identify and target key drivers of neuroblastoma in mouse models, the authors reported in the November 3, 2021, issue of Nature.
A study led by researchers at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, has shown that amygdala kappa-opioid receptor-dependent upregulation of glutamate transporter 1 mediates depressive-like behaviors in mouse models of opiate abstinence.
Attaching a modified bacterial-derived formyl peptide chemoattractant to an antibiotic enhanced recruitment of neutrophils and improved their bactericidal ability in mouse models, according to a study led by European Molecular Biology Laboratory Australia researchers at Monash University in Melbourne.
The Cancer Grand Challenges Mutographs study, a combined genetic and epidemiological analysis of data from eight countries with widely different incidences of esophageal squamous cell carcinomas (ESCC), has unexpectedly failed to identify mutational signatures indicating DNA damage that could account for global ESCC incidence variations.
The proinflammatory cytokine macrophage migration inhibitory factor has been demonstrated to drive the induction and progression of spondyloarthritis in mice and to be associated with human disease, according to the findings of an international study led by researchers at the University of Toronto in Ontario, Canada.
A new engineered glycated vaccine induced production of neutralizing antibodies against severe acute respiratory coronavirus 2 (SARS-CoV-2) and other coronaviruses in mice, scientists at The University of Osaka and the RIKEN Center for Integrative Medical Science in Yokohama have reported.
Pretreatment with an experimental focal adhesion kinase inhibitor has been shown to improve chemotherapeutic efficiency and reduce metastasis in preclinical mouse and patient-derived models of pancreatic ductal adenocarcinoma (PDAC), with this priming regimen soon to enter phase II trials for PDAC using a novel, clinically relevant FAK inhibitor.
A novel pharmacologically targetable metabolic mechanism driving resistance to epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitors (TKIs) has been identified in preclinical models of lung cancer in a Chinese study led by scientists at Shanghai Jiao Tong University School of Medicine.
Blocking the interaction between two dengue virus (DENV) nonstructural proteins, NS3 and NS4B, with a newly developed small-molecule inhibitor resulted in potent antiviral activity in mouse models, according to an international collaborative study led by scientists at the University of Leuven (KU Leuven), CD3 the Centre for Drug Design and Discovery in Leuven, and Janssen Pharmaceutica in Beerse, Belgium.
