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Home » Topics » Drugs » Antibody

Antibody
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Radiotherapy of cancer

Actinium sinks on BLA delay for radiotherapy candidate Iomab-B

Aug. 5, 2024
By Jennifer Boggs
The possibility of a 2025 approval looks to be off the table for Actinium Pharmaceuticals Inc.’s Iomab-B, at least in the U.S. In a move that H.C. Wainwright analyst Joseph Pantginis dubbed “a major surprise,” the FDA has requested a head-to-head study demonstrating overall survival before it will consider approving the radiotherapy candidate for use in patients with active relapsed or refractory acute myeloid leukemia.
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Illustration of diseased kidney
Nephrology

Latent TGF-β1 complex inhibitor avoids renal fibrosis

Aug. 5, 2024
An antibody that binds to the latent form of transforming growth factor-β1 (TGF-β1) prevented its release into the extracellular matrix and reduced the progression of fibrosis in the kidney. TGF-β is synthesized and secreted into the extracellular matrix in a latent inactive form associated with the latency peptide.
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Vir announces Sanofi deal, pipeline overhaul

Aug. 2, 2024
By Jennifer Boggs
Vir Biotechnology Inc.’s focus will look a little different for the latter half of 2024, as the San Francisco-based firm disclosed a restructuring that will cut about a fourth of its workforce and phase out programs targeting influenza and COVID-19 as well as vaccines developed using its T-cell-based viral vector platform.
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LTZ raises $20M to bring LTZ-301 to clinic for B-cell tumors

Aug. 1, 2024
By Tamra Sami
Immunotherapy-focused biotech company LTZ Therapetics Inc. raised $20 million in a series A round that will advance development of its myeloid engager pipeline to treat cancer and autoimmune diseases. Proceeds from the funds will accelerate development of lead asset LTZ-301, which is expected to enter the clinic in early 2025, LTZ founder and CEO Robert Li told BioWorld.
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Handshake with globe background and digital overlay

$2B+ at stake for Immuneonco in rights deal with Instil Bio

Aug. 1, 2024
By Lee Landenberger
Instil Bio Inc. plans re-energize the company by in-licensing the development and commercial rights to antibodies outside of China from Shanghai-based Immuneonco Biopharmaceuticals Inc. In return, Immuneonco is getting an undisclosed up-front payment and the chance for near-term payments of up to $50 million.
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Obesity, fat cell research concept image
Inflammatory

Zyversa selects lead indication for ASC inhibitor IC-100

Aug. 1, 2024
Zyversa Therapeutics Inc. announced it has selected obesity and its related metabolic complications as the lead indication for its ASC protein inhibitor IC-100. One consequence of high weight is chronic inflammation, which increases the risk of multiple metabolic and cardiovascular disorders.
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Hepatitis B virus rendering
Infection

Recombinant polyclonal HBV therapy cleared to enter clinic

Aug. 1, 2024
Gigagen Inc., a subsidiary of Grifols SA, has received clearance from the FDA of its IND application to conduct a phase I trial of GIGA-2339 for the treatment of hepatitis B virus (HBV) infections.
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Antibodies (light blue) and G protein-coupled receptors (purple)
Newco news

Alkira Bio exits stealth via seed round to develop GPCR-targeting antibodies

July 30, 2024
By Tamra Sami
Alkira Bio, a new spinout from Australia’s Florey Institute of Neuroscience and Mental Health has emerged from stealth mode thanks to seed funding from Curie.bio. Although the amount of funding is not disclosed, Curie.bio typically invests $5 million to $10 million in a founder company and then co-pilots the drug discovery program, deploying drug development experts to its portfolio companies to help navigate decision making as part of the deal, Florey researcher turned Alkira Bio CEO Daniel Scott told BioWorld.
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Monoclonal antibody illustration

European Commission approves Cstone PD-L1 sugemalimab in NSCLC

July 30, 2024
By Tamra Sami
The European Commission has approved Cstone Pharmaceuticals Ltd.’s PD-L1 monoclonal antibody, sugemalimab, in combination with platinum-based chemotherapy for first-line treatment of adults with metastatic non-small-cell lung cancer with no sensitizing EGFR mutations, or ALK, ROS1 or RET genomic tumor aberrations.
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Antibodies (light blue) and G protein-coupled receptors (purple)
Neurology/psychiatric

Alkira Bio exits stealth via seed round to develop GPCR-targeting antibodies

July 30, 2024
By Tamra Sami
Alkira Bio, a new spinout from Australia’s Florey Institute of Neuroscience and Mental Health has emerged from stealth mode thanks to seed funding from Curie.bio. Although the amount of funding is not disclosed, Curie.bio typically invests $5 million to $10 million in a founder company and then co-pilots the drug discovery program, deploying drug development experts to its portfolio companies to help navigate decision making as part of the deal, Florey researcher turned Alkira Bio CEO Daniel Scott told BioWorld.
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