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Home » Topics » Regulatory » Patents

Patents
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Ocular

Roche identifies MMP-9 inhibitors for dry eye

June 10, 2025
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have patented 5-[2,7-diazaspiro[3.5]nonan-7-yl]-5-[4-phenoxyphenyl]hexahydropyrimidine-2,4,6-trione derivatives acting as matrix metalloproteinase-9, (MMP-9) inhibitors potentially useful for the treatment of dry eye.
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Gastrointestinal

17β-HSD13 inhibitors described in Astrazeneca patent

June 10, 2025
Astrazeneca AB has reported the identification of 17β-hydroxysteroid dehydrogenase 13 (HSD17B13; 17β-HSD13) inhibitors reported to be useful for the treatment of nonalcoholic steatohepatitis (NASH; MASH), among others.
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Endocrine/metabolic

Lilly patents RXFP1 agonists

June 10, 2025
An Eli Lilly & Co. patent describes new relaxin receptor 1 (RXFP1; LGR7) agonists potentially useful for the treatment of diabetes, stroke, atherosclerosis and more.
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Canceling claims not an appropriate sanction, USPTO says

June 9, 2025
By Mari Serebrov
No Comments
Absent extraordinary circumstances, the Patent Trial and Appeal Board “should never cancel claims it has not determined to be unpatentable as a sanction” for misconduct during a board proceeding, according to the acting director of the U.S. Patent and Trademark Office (USPTO).
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Nephrology

Vertex Pharmaceuticals discovers new PKD1 correctors

June 6, 2025
Vertex Pharmaceuticals Inc. has described polycystin-1 (PKD1) (mutant) correctors reported to be useful for the treatment of autosomal dominant polycystic kidney disease.
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Gastrointestinal

New 17β-HSD13 inhibitors disclosed in Astrazeneca patents

June 6, 2025
Astrazeneca AB has divulged 17β-hydroxysteroid dehydrogenase 13 (HSD17B13; 17β-HSD13) inhibitors reported to be useful for the treatment of alcoholic liver disease, liver fibrosis, cirrhosis, hepatic steatosis, liver inflammation, hepatitis C virus (HCV) infection and liver cancer (hepatocellular carcinoma).
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Neurology/psychiatric

Merck Sharp & Dohme describes new HCN1 and HCN2 blockers

June 6, 2025
Merck Sharp & Dohme LLC has identified compounds acting as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and/or 2 (HCN2) blockers reported to be useful for the treatment of neuropathic pain, tinnitus, psychiatric and neurological disorders.
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Infection

Gilead Sciences divulges new compounds to treat herpes virus infection

June 6, 2025
Gilead Sciences Inc. has synthesized indoline compounds acting as DNA helicase-primase complex (human herpes simplex virus) and viral replication inhibitors reported to be useful for the treatment of herpes virus infection.
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Dermatologic

Biogen patents new TYK2 inhibitors

June 6, 2025
Biogen Inc. has disclosed non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of stroke, psoriasis, arthritis, pain, silicosis, alopecia and more.
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Cancer

Kumquat Biosciences discovers new GTPase KRAS wild-type and mutant inhibitors

June 5, 2025
Kumquat Biosciences Inc. has described compounds acting as GTPase KRAS wild-type and mutant inhibitors reported to be useful for the treatment of cancer.
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