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Home » Newsletters » BioWorld

BioWorld

July 24, 2012

View Archived Issues

At AIDS Meeting, Optimism Despite Long Road Ahead

WASHINGTON – Perhaps nothing illustrates the sense of hope that pervades the 19th International AIDS Conference being held in Washington this week like a much-repeated anecdote – told at least three time in as many sessions – about the casketmaker in Lesotho complaining about how much business is down due to the increased survival times of HIV-infected individuals. Read More

Histogenics $49M Round to Advance NeoCart Implant

Regenerative medicine developer Histogenics Corp. said Tuesday that it completed a $49 million financing to complete its ongoing Phase III program for lead candidate NeoCart, an autologous neocartilage tissue implant that utilizes a patient's own cells to regenerate articular cartilage in the knee. The trial is currently enrolling patients. Read More

Protein Takes on New Job, and Scientific Dogma, by Refolding

The notion that one gene can make only one protein, once a central tenet of molecular biology, has long since been revised. One gene can make several proteins through alternative splicing. Read More

Investors Step Up for PTC's $30M Round for DMD Trials

Following encouraging results from a Phase III trial, PTC Therapeutics Inc., of South Plainfield, N.J., completed a $30 million financing to support late-stage development of ataluren. The drug has showed clinically meaningful trends in Duchenne's and Becker muscular dystrophy and cystic fibrosis. Read More

Cell Medica Adds $26.5M via Public, Private Funding Round

LONDON – Cell therapy specialist Cell Medica Ltd. has raised £17 million (US$26.5 million) in a mixture of public and private funding, including a grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to be devoted to setting up manufacturing and running a clinical trial in the state. Read More

Stock Movers

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Other News To Note

• Oxford BioMedica plc, of London, said the U.S.-based Foundation Fighting Blindness granted it a $125,000 award to support the opening of a second trial site in Paris for the UshStat Phase I/IIa study. A gene-based treatment for Usher syndrome Type 1B, UshStat is the third ocular product to enter clinical development under Oxford's collaboration with Sanofi SA, of Paris. The open-label, dose-escalation trial was initiated in February in the U.S., where it will enroll up to 18 patients. The Paris site is expected to open early next year. Read More

Clinic Roundup

• Cerulean Pharma Inc., of Cambridge, Mass., said it dosed the first patient in a Phase II study testing CRLX101 in platinum-resistant ovarian cancer. The study is designed to test the drug, a nanopharmaceutical that inhibits both topoisomerase 1 and hypoxia-inducible factor-1 alpha, in patients whose disease has progressed following standard first-line platinum-based therapy. Read More

Earnings Roundup

• InterMune Inc., of Brisbane, Calif., reported net second-quarter revenue of $5.5 million for Esbriet (pirfenidone) and said it reached agreement on a reimbursement price of €26,999 (US$33,000) per patient per year in Germany, a discount of about 10 percent from the current price. Read More

Pharma: Other News To Note

• Sandoz Inc., a unit of Basel, Switzerland-based Novartis AG, said it completed its $1.525 billion acquisition of specialty U.S. dermatology company Fougera Pharmaceuticals Inc.. Read More

Pharma: Clinic Roundup

• Kowa Pharmaceuticals America Inc., of Montgomery, Ala., and Eli Lilly and Co., of Indianapolis, released results from a pharmacokinetic study exploring potential drug interaction between cholesterol medication Livalo (pitavastatin) 4 mg and protease inhibitor combo Prezista/Norvir (darunavir, Tibotec Pharmaceuticals Ltd./ritonavir, Abbott) 800 mg/100 mg in healthy volunteers. Read More

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