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Home » Newsletters » BioWorld

BioWorld

Aug. 30, 2021

View Archived Issues
Knee pain illustration

Bone Therapeutics shares drop 36% on phase III miss in osteoarthritic pain

DUBLIN – Shares in Bone Therapeutics SA dropped by as much as 38% Aug. 30 after the regenerative medicine firm reported that its lead program, JTA-004, flopped in a phase III trial in osteoarthritis of the knee. The candidate therapy, designed to lubricate and protect damaged cartilage in affected joints, failed to meet the primary endpoint of being superior to placebo in reducing pain, as measured on the Western Ontario McMaster Universities Osteoarthritis Index (Womac) pain subscale three months after treatment. Read More
RNA.png

Laronde rounds up $440M to further advance 'endless' RNA platform

Laronde Inc., a company developing a new class of closed-loop RNA constructs for future medicines, has raised $440 million in series B financing. Unfurling at a pivotal moment for RNA-based therapies and vaccines, the company's approach is a bet on early evidence that its "endless" RNA loops can produce stable, enduring and tunable protein expression to fight disease. Read More
Drug research

CBO’s H.R. 3 forecast not so sunny for U.S. drug innovation

Sure H.R. 3 could save the U.S. government hundreds of billions of dollars on drug spending, but that savings comes at a long-term cost in innovation that’s higher than the Congressional Budget Office (CBO) initially forecast. Read More

New Nrx COVID-19 data show improved lung function

New data from Nrx Pharmaceuticals Inc.’s phase IIb/III trial for treating acute respiratory failure due to critical COVID-19 showed that Zyesami (aviptadil) improved the lung’s ability to transmit oxygen within a day of administration. The respiratory distress ratio’s average difference between those participants receiving aviptadil and placebo was clinically meaningful and statistically significant. The benefit was found across participants, all baseline severities and hospitals of all types. Read More
Coronavirus vaccine illustration

ACIP unanimously backs Pfizer/Biontech vaccine; booster data in October?

The CDC’s Advisory Committee on Immunization Practices (ACIP) heard a safety update on COVID-19 vaccines, took up the matter of booster shots, and voted on whether to recommend the vaccine from Pfizer Inc. and Biontech SE for people 16 and older, now that it’s fully licensed. Under an emergency use authorization, the vaccine can be given to people 12-15 years old. Read More
Cancer-and-Cancer-immunotherapy.png

Binhui moves HSV-2-based oncolytic viral candidate toward U.S. trial

Binhui Biopharmaceutical Co. Ltd.’s BS-001, a recombinant human oncolytic herpes simplex virus type-2 expressing GM-CSF for the potential treatment of solid tumors, has gained an IND approval from the FDA. The development marks the first oncolytic viral candidate developed by a Chinese company to win a go-ahead for trials abroad, it said. Read More
ICYMI illustration

ICYMI: Week in review, Aug. 23-27, 2021

A quick look back at top stories. Read More

Appointments and advancements for Aug. 30, 2021

New hires and promotions in the biopharma industry, including: Boundless, Convergent, Enochian, Galectin, H3, Rubius, Therapeutic Solutions, Xbiotech, Ziopharm. Read More

Financings for Aug. 30, 2021

Biopharmas raising money in public or private financings, including: Innocan, Meletios, Mynd, Neuexcell, Rocket. Read More

In the clinic for Aug. 30, 2021

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Agenus, Aileron, Airway, Alzecure, Amgen, Ose, Quantum. Read More

Other news to note for Aug. 30, 2021

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Immunobrain, Insilico, Noxopharm, Satellos, Sorrento, Tilt, Tumorgen. Read More

Regulatory actions for Aug. 30, 2021

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Abbvie, Biomarin, Enzene, Incyte, Junshi, Laekna, Morphosys, Pendopharm, Roche. Read More

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