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Home » Newsletters » BioWorld

BioWorld

June 6, 2022

View Archived Issues
Enhertu.png

Swing low, sweet Enhertu: Astrazeneca, Daiichi ASCO data carry HER2 message home

The “showdown” at the American Society of Clinical Oncology (ASCO) meeting foreseen by one analyst between breast cancer drugs from Gilead Sciences Inc. and Astrazeneca plc with partner Daiichi Sankyo Co. Ltd. didn’t quite materialize. Or the showdown happened, but turned out more nuanced than a one-to-one, high-noon gunfight on Main Street. Gilead ended considerable suspense June 4 by offering at ASCO phase III data from the Tropics-02 study with Trodelvy (sacituzumab govitecan), expectations for which already had grown lukewarm. Astrazeneca and Daiichi dazzled the next-day meeting with phase III data from the Destiny-Breast04 (DB04) study with Enhertu (fam-trastuzumab deruxtecan). Read More

Tropics-02 of cancer revealed at last, miller Gilead fine-grinds Trodelvy breast results at ASCO

After weeks of mounting speculation by backers of Gilead Sciences Inc., data from the phase III Tropics-02 study testing Trodelvy (sacituzumab govitecan) vs. physicians’ choice of chemotherapy rolled out June 4 at the American Society of Clinical Oncology (ASCO) meeting in Chicago. Wall Street had hoped for better. Read More
Cancer cells

Merus tees up ‘tumor agnostic’ filing for zenocutuzumab after impressing at ASCO

Could Merus NV be on course to get the fourth “tumor agnostic” drug approved, a groundbreaking approach to cancer that focuses on mutations rather than location of the disease? According to a trial update revealed at the American Society of Clinical Oncology (ASCO) conference the biotech from Utrecht, the Netherlands, could join Merck & Co Inc., Bayer AG/Eli Lilly and Co. and Roche Holding AG with its early-to-mid stage candidate, zenocutuzumab. Read More

Praxis to refocus after a failed phase II/III depression study

Following a negative phase II/III study of an investigational treatment for major depressive disorder, Praxis Precision Medicines Inc. is dropping staff from the payroll and refocusing the company’s resources on tremor and epilepsy. The Aria study of PRAX-114, a positive allosteric modulator extrasynaptic GABA receptor, missed its primary endpoint, statistical significance as measured on the Hamilton Depression Rating Scale. It also missed the study’s secondary endpoints. Read More
Colorectal cancer

Takeda-Amgen treatment improves survival in metastatic colorectal cancer

Five-year survival rates for people with metastatic colorectal cancer haven’t budged much in recent decades but new data presented at the American Society of Clinical Oncology’s annual conference pushed the boundary enough to be notable. Read More
Colorful illustration of the heart

Luca lands $30.3M series B for mitochondrial heart attack therapy

Luca Science Inc. has raised $30.3 million in an oversubscribed series B financing, enabling it to advance a mitochondria replacement therapy toward the clinic. The company is planning a phase Ib trial in myocardial infarction, in which 8 to 12 patients will receive injections of mitochondria immediately after having a heart attack. Read More

Minding the gap: ASCO and WHO focus on improving global cancer care

Building on years of informal collaboration, the American Society of Clinical Oncology (ASCO) and the World Health Organization (WHO) said they plan to measure and improve cancer care an equity gap of cancer care around the world. Read More

ICYMI: Week in review, May 30-June 3, 2022

A quick look back at top stories.

Read More

The BioWorld Insider Podcast: New therapies vie to change fatal course of amyotrophic lateral sclerosis

As multidisciplinary care extends survival and improves the quality of life for people with amyotrophic lateral sclerosis (ALS), can a host of new ALS drugs vying to slow its progression make a difference? Join the BioWorld Insider podcast as we discuss what the future of medicine may hold for ALS patients. Read More

Appointments and advancements for June 6, 2022

New hires and promotions in the biopharma industry, including: Amarin, Ambrx, Gilead, Iconovir, Immune, Mirum, Sionna, Third Harmonic, Xortx. Read More

Conference data for June 6, 2022: ADA

New and updated preclinical and clinical data presented by biopharma firms at the American Diabetes Association's 82nd Scientific Sessions, including: Biomea, Eli Lilly, Gelesis, Vtv. Read More

Conference data for June 6, 2022: ASCO

New and updated preclinical and clinical data presented by biopharma firms at the American Society of Clinical Oncology annual meeting, including: Bicara, G1, Intensity, Janssen, Kazia, Oncxerna, PTC. Read More

Financings for June 6, 2022

Biopharmas raising money in public or private financings, including: Aquestive, Insilico Medicine, Polarityte, Shuttle. Read More

In the clinic for June 6, 2022

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Acelyrin, Affibody, Alx, Aurinia, Biogen, Biothera, Incannex, Inmagene, Intercept, Merck, Nicox, Novo Nordisk, Olix, Sorrento, Tranquis. Read More

Other news to note for June 6, 2022

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Adelia, Alectos, Alvotech, Amarin, Argenx, Biogen, Cybin, Eureka, Janssen, J&J, Kineta, Medison, Oaktree, Ovid, Sparrow, Tetra, Yumanity. Read More

Regulatory actions for June 6, 2022

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Amylyx, Applied, J Ints, Legend. Read More

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