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Home » Newsletters » BioWorld

BioWorld

Aug. 9, 2022

View Archived Issues
Antibodies

Mersana scores $100M up front for preclinical STING ADC in potential $1.5B GSK deal

Mersana Therapeutics Inc. is getting $100 million up front in an option deal with GSK plc for preclinical-stage antibody-drug conjugate (ADC) XMT-2056, which could bring up to $1.36 billion more in an option exercise payment, development, regulatory and commercial milestones. It’s the second potential $1 billion-plus ADC deal for Cambridge, Mass.-based Mersana in 2022 and the first for its Immunosynthen platform, which uses a STING agonist payload specifically designed for ADCs. Read More

Merck & Co. looks beyond amyloid beta, signing potential $1.1B Alzheimer’s R&D deal with Cerevance

Central nervous system specialist Cerevance Inc. has announced a multiyear strategic research collaboration with Merck & Co. Inc. to identify novel targets for Alzheimer’s disease in a deal worth more than $1.1 billion, plus royalties. Boston-based Cerevance will receive $25 million up front with the $1.1 billion due when certain development and commercial milestones are achieved. Read More
Scientist, microscope and dropper

Innovent, Sanofi to co-develop two oncology drugs in China with €300M investment

Innovent Biologics Inc. has formed a partnership with Sanofi SA to jointly develop and commercialize two of Sanofi’s oncology candidates in combination with sintilimab in China, namely SAR-408701 (tusamitamab ravtansine) and SAR-444245. Read More

Breathing easier: Verona’s phase III in COPD hits primary and secondary endpoints

Top-line data from Verona Pharma plc’s phase III ENHANCE-2 study show its inhaled ensifentrine hit the primary and secondary endpoints in treating chronic obstructive pulmonary disease (COPD). Next up: data from the companion phase III, ENHANCE-1, which is expected by the end of 2022. Read More
respiratory-lung-COVID-19-coronavirus.png

Taiwan’s Syneurx gears up for phase III test of COVID-19 oral antiviral

Following the readout of a phase II trial evaluating its COVID-19 oral antiviral Pentarlandir (SNB-01), Taiwan’s Syneurx International Corp. said it expects to launch a phase III test of the candidate in the next few months. Read More

Hutchmed planning regulatory submissions on fruquintinib CRC data

It’s an august August for Hutchmed Ltd. as it reported positive business results and a number of trial developments, including results from its pivotal global phase III FRESCO-2 trial evaluating the investigational use of fruquintinib in patients with advanced, refractory metastatic colorectal cancer, which met its primary endpoint of overall survival. Read More

FDA approves Daiichi Sankyo/Astrazeneca’s Enhertu for HER2 low metastatic breast cancer

The U.S. FDA has approved Daiichi Sankyo Co. Ltd. and Astrazeneca plc’s Enhertu (fam-trastuzumab deruxtecan) as the first HER2-directed therapy for patients with HER2-low metastatic breast cancer. Read More

Nothing misleading here, US First Circuit tells Karyopharm investors

An investor’s wish to know more about the total landscape of a drug candidate is not enough, on its own, to make a company’s disclosures about the drug and its development materially misleading. So said the U.S. Court of Appeals for the First Circuit in affirming the dismissal of a shareholder suit against Karyopharm Therapeutics Inc. and its executive officers. Read More

Appointments and advancements for Aug. 9, 2022

New hires and promotions in the biopharma industry, including: Arcus, Third Harmonic. Read More

Financings for Aug. 9, 2022

Biopharmas raising money in public or private financings, including: Blue, Clearside, Cybin, Epigenic, Rani. Read More

In the clinic for Aug. 9, 2022

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Ascletis, Astrazeneca, Cincor, Cocrystal, Cstone, Daiichi, Eqrx, Hutchmed, Innovent, Karuna, Kodiak, Neuren, Sapience. Read More

Other news to note for Aug. 9, 2022

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Bioduro-Sundia, Calcimedica, Fate, Oligomerix, Opiant, Persephone, Sarepta, Sellas, Siga, X-Chem. Read More

Regulatory actions for Aug. 9, 2022

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Astrazeneca, Bayer, Daiichi, Immvira, Myovant, Orion, Scisparc, Tracon. Read More

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