A rare cell type in the gut, the enterochromaffin (EC) cell, drove both gut discomfort and anxiety symptoms in animal models of gastrointestinal pain. Furthermore, the cells reacted differently in male and female mice, opening up new ways to understand and investigate the higher prevalence of gut disorders in women. Read More
Hunan Warrant Pharmaceutical Technology Development Co. Ltd. has disclosed data on the identification of a novel small-molecule inhibitor of Bruton tyrosine kinase (BTK), HND-01, which was identified by modifying metabolite 20 of dasatinib and is being developed for the potential treatment of cancer. Read More
Researchers from Atyr Pharma Inc. presented findings from the innovative tRNA synthetase platform, highlighting ATYR-0101, a potential therapeutic biologic based on a domain appended to aspartyl-tRNA synthetase (DARS). Read More
Captor Therapeutics SA has offered an update on its lead programs CT-01, CT-02 and CT-05. In the CT-01 program, CPT-6281 is currently undergoing IND/CTA-enabling studies with the first clinical trial expected to start at the end of the year. The first indication will be in hepatocellular carcinoma (HCC). Read More
(Azacycloalkyl)methoxy-substituted benzamides acting as trace amine-associated receptor 1 (TAAR1; TAR1) agonists have been described in a recent Accellena Research and Development LLC patent. Read More
Necroptosis is a well-controlled process of programmed necrosis present in inflammatory disorders mainly regulated by RIPK1, RIPK3 and mixed-lineage kinase domain-like pseudokinase (MLKL). Read More
Shionogi & Co. Ltd. has developed fused heterocyclic derivative HIV replication inhibitors reported to be useful for the treatment of HIV infections. Read More
Prostate cancer is the second most prevalent solid tumor in men and the fifth leading cause of cancer mortality in men worldwide. One of the proteins overexpressed in prostate cancer is serine/threonine-protein kinase PIM-1. There is evidence about the potential role of PIM-1 as a target in prostate cancer and the effect in cellular apoptosis that reducing levels of PIM-1 through its inducers JAK2/STAT3 may exert. Read More
Research at KHR Biotec GmbH has led to the development of eukaryotic initiation factor 4A (elF4A) and GTPase mutant inhibitors potentially useful for the treatment of cancer, craniofacial syndrome and neurofibromatosis type I. Read More
Mitogen-activated protein kinase kinase kinase 13 (MAP3K13; LZK) inhibitors reported to be useful for the treatment of cancer have been described in a recent U.S. Department of Health and Human Services patent. Read More
Researchers from Shanxi Medical University and affiliated organizations presented data from a study that aimed to analyze the expression and prognostic value of mitochondrial-related genes in patients with stomach adenocarcinoma (STAD). Read More
Metabolic-associated fatty liver disease (MAFLD) is a condition that encompasses a range of liver disorders, from steatosis to fibrosis. In a recent study, researchers investigated the role of phosphoenolpyruvate carboxykinase 1 (PCK1) in MAFLD progression in vivo. This work found that deficiency of the gluconeogenic enzyme PCK1 promoted the development of MAFLD through activation of the PI3K/AKT/PDGF axis. Read More
Spark Biopharma Inc. has prepared and tested stimulator of interferon genes protein (STING; TMEM173) agonists that are reported to be useful for the treatment of cancer. Read More
COVID-19 complications involve activated T cells that contribute to inflammation. Foralumab, a fully human anti-CD3 monoclonal antibody, targets the T-cell receptor and regulates T-cell function to suppress inflammation. In a pilot trial, foralumab reduced lung inflammation, serum IL-6 and C-reactive protein in cases of moderate COVID-19. Read More
