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Home » Newsletters » BioWorld Science

BioWorld Science

May 31, 2023

View Archived Issues
Bladder of a mouse that was reinfected with E. coli

Memory T cells control immunity to urinary reinfection

Urinary tract infections (UTIs) are often recurrent. The organism does not always establish an effective line of defense that protects from reinfection. The key lies in two reservoirs of bacteria and how tissue-resident memory T cells (TRMs) trigger the immune response. A recent paper from the Pasteur Institute in France describes how these cells mediate immunity to defeat reinfection. Read More
Joint pain illustration

Adolore comes to the fore with CA8 chronic pain gene therapy

With overuse of opioids – the standard of care for many chronic pain cases – becoming something of an epidemic in the U.S., the availability of an alternative, non-opioid analgesic is a big draw. Established in 2021, Adolore Biotherapeutics Inc. is one company that could provide the answer, with its locally and long-acting gene therapies potentially providing a breakthrough that “knocks everybody’s socks off.” Read More
Illustration of coronavirus blocked by the no symbol

Novel nonpeptidic SARS-CoV-2 3CLpro inhibitor demonstrates good antiviral activity

In the effort to tackle the recent global SARS-CoV-2 pandemic, multiple peptide-like covalent SARS... Read More
Kidney nephron illustration with parts labeled, including podocytes and juxtaglomerular cells

Melanocortin MC1 receptor agonist from Palatin protects against diabetic nephropathy in rats

Podocytes are specialized cells in the glomerulus that support and maintain glomerular capillary... Read More

Shanghai Xucheng Pharmatech patents new DNA repair protein RAD51 homolog 1 inhibitors

Shanghai Xucheng Pharmatech Co. Ltd. has disclosed DNA repair protein RAD51 homolog 1... Read More
Illustration of antibodies binding to human cell receptors

Preclinical evaluation of AP-203, a bispecific antibody that simultaneously targets PD-L1 and CD137

Researchers from AP Biosciences Inc. have published preclinical data for a new bispecific... Read More

Chinese researchers divulge new GSPT1 degraders for cancer

Researchers at Fudan University and Shanghai Meizer Pharmaceuticals Co. Ltd. have... Read More
AI-network-machine-learning.png

Xtalpi brings AI capabilities and robotics platform to Eli Lilly drug discovery collaboration

Xtalpi Inc. has entered into an artificial intelligence (AI) drug discovery collaboration with Eli Lilly & Co. The collaboration, valued at up to $250 million in upfront and milestone payments, will leverage Xtalpi’s integrated AI capabilities and robotics platform to de novo design and deliver drug candidates for an undisclosed target. Xtalpi seeks to deliver a novel compound, which Lilly will pursue in clinical and commercial development. Read More

Study reveals that cisplatin resistance can be eliminated by inhibition of TRPV1

Treatment failure after repeated administration of cisplatin, one of the most used cancer chemotherapeutics, is due to either development of treatment resistance or chemotherapy-induced neuropathic pain. Read More

National Institute of Pharmaceutical R&D describes new TLR8 agonists

National Institute of Pharmaceutical R&D Co. Ltd. has identified Toll-like receptor 8 (TLR8) agonists reported to be useful for the treatment of cancer and viral infections. Read More
Microglia and myelin

ARG1-positive microglia serve neurodevelopmental functions

While microglia constitute the immune cells of the brain, their potential role in the early development of neuronal circuitry is poorly understood. Investigators at the Karolinska Institutet, together with eight other institutions, characterized an anatomically distinct microglial cell population identified as expressing the arginase-1 (ARG1) enzyme. Read More

New Far1 KO mouse model unveils the essential role of ether lipids in spermatogenesis

Ether lipids (EL) are glycerophospholipids with a different structure and functional characteristics than fatty acids, thus requiring a specialized biosynthesis pathway. Peroxisomal fatty acyl-CoA reductase 1 (FAR1) is a rate-limiting enzyme for ether lipid synthesis, with mutations associated with a rare human disease. Moreover, altered EL homeostasis has been observed in various prevalent human diseases. Read More

Chongqing Fochon Pharmaceuticals presents new Bcl-2 inhibitors

Chongqing Fochon Pharmaceuticals Co. Ltd. has divulged apoptosis regulator Bcl-2 inhibitors reported to be useful for the treatment of cancer, Addison’s disease, allergy, asthma, atherosclerosis, ankylosing spondylitis, Alzheimer’s disease and systemic lupus erythematosus, among others. Read More
Central nervous system

MYO9B gene mutations tied to CMT2 and optic atrophy, study finds

Charcot-Marie-Tooth disease (CMT) is a group of neuropathies characterized by sensory and motor dysfunction that progress with aging. It is considered that about 60% of the axonal forms of the disease, such as CMT2, remain genetically undiagnosed. Read More

Frontier Medicines discovers new GTPase KRAS mutant inhibitors for cancer

Frontier Medicines Corp. has described GTPase KRAS (G12C mutant) inhibitors reported to be useful for the treatment of cancer. Read More

Other news to note for May 31, 2023

Additional early-stage research and drug discovery news in brief, from: Amplia Therapeutics, Can-Fite Biopharma, Imunon, Lixte Biotechnology, Regcell. Read More

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