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Home » Newsletters » BioWorld Science

BioWorld Science

Sep. 19, 2023

View Archived Issues
Art concept for gene therapy research

Machine learning tool Alphamissense analyzes human mutations to predict diseases

Proteome analysis with artificial intelligence has made it possible to create a catalog of all possible missense mutations in the human genome to predict diseases. The new Alphamissense tool from the technology company Google Deepmind, available online, will allow scientists to refine diagnoses and design more tailored treatment strategies for patients suffering from pathologies associated with these variants. Read More

Novel pleuromutilin derivatives show efficacy in drug-resistant infections

The development of novel antimicrobial agents is crucial to combat the emergence of multidrug-resistant bacteria, which cause millions of deaths and high economic losses. Researchers from Shaanxi University of Science & Technology and colleagues reported on the design and optimization of new pleuromutilin derivatives intended for use as antibacterial drugs against multidrug-resistant gram-negative bacteria. Read More
respiratory-lung.png

BTI-615 inhibits TGF-β1 signaling and suppresses lung fibrosis in rats

Transforming growth factor β1 (TGF-β1) is a key mediator of the fibrotic response, and its dysregulation drives the formation of the fibrotic niche, which impairs the capacity of tissue repair, regeneration and homeostasis. Read More
Cancer cells under magnifying glass

Kayothera selects retinoid pathway inhibitor as development candidate

Kayothera Inc. has selected KAYO-1609, an oral retinoid pathway inhibitor, as its first drug development candidate. Read More

Potent AR antagonist shows AR degrading activity and antitumor efficacy in prostate cancer models

Researchers from China Pharmaceutical University and Nanjing First Hospital synthesized and optimized a novel series of thiohydantoin based compounds leading to the discovery of candidate [I] as the lead androgen receptor (AR) antagonist (IC50=1.46 µM). Read More
Illustration of digital syringe

Evaxion partners to advance new bacterial vaccine program

Evaxion Biotech A/S has announced the initiation of a novel pipeline program, EVX-B3, an artificial intelligence (AI)-designed vaccine candidate against an undisclosed bacterial pathogen. The new vaccine project will be the subject of a co-funded collaboration between Evaxion and an undisclosed partner. Read More

Korean researchers patent new prostanoid EP2 and EP4 receptor dual antagonists for cancer

Researchers from Kanaph Therapeutics Inc. and Korea Research Institute of Chemical Technology have disclosed prostanoid EP2 and/or EP4 receptor subtype dual antagonists reported to be useful for the treatment of cancer. Read More

Lapix’s TIM-3/4 receptor agonist cleared to enter clinic for multiple sclerosis

Lapix Therapeutics Inc. has received IND clearance from the FDA to initiate a phase I trial of its first-in-class, immune tolerance restoration small molecule, LPX-TI641, for the treatment of multiple sclerosis (MS). Read More

Viva Star Biosciences divulges new NLRP3 inflammasome inhibitors

Viva Star Biosciences (Suzhou) Co. Ltd. has synthesized NLRP3 inflammasome inhibitors reported to be useful for the treatment of cryopyrin-associated periodic syndrome, multiple sclerosis, atherosclerosis, type 2 diabetes, osteoarthritis, cancer, Alzheimer’s disease and Parkinson’s disease. Read More
Amyloid plaque on nerve cell

Irisin reduces amyloid-β levels in 3D culture models of Alzheimer’s disease

Irisin is a myokine derived from fibronectin type III domain containing 5 (FNDC5) released into the circulation during physical exercise. It is known that FNDC5/irisin stimulates brain-derived neurotrophic factor (BDNF) expression in the hippocampus and also that Alzheimer’s disease (AD) models and brains and cerebrospinal fluid of AD patients have low levels of irisin. Read More

Lhotse Bio describes new LPA1 receptor antagonists

Lhotse Bio Inc. has identified lysophospholipid LPA1 receptor (LPAR1; EDG2) antagonists reported to be useful for the treatment of cancer, fibrosis, chronic obstructive pulmonary disease, multiple sclerosis, inflammatory disorders, SARS-CoV-2 infection (COVID-19), transplant rejection and osteoporosis, among others. Read More

Pharmabcine’s anti-VISTA antibody PMC-309 receives Australian HREC clearance for phase I study in solid tumors

Pharmabcine Inc. has received approval from the human research ethics committee (HREC) in Australia for a phase Ia/b trial of PMC-309, a monoclonal antibody against the human V-domain Ig suppressor of T-cell activation (VISTA) ligand. Read More
Concept art for adeno-associated viral-based gene therapy.

Atamyo files CTA in Europe for ATA-200 gene therapy for limb-girdle muscular dystrophy type 2C/R5

Atamyo Therapeutics SAS has filed a clinical trial application (CTA) in Europe for ATA-200, its gene therapy targeting γ-sarcoglycan (SGCG)-related limb-girdle muscular dystrophy type 2C/R5 (LGMD-R5). Read More

Medshine Discovery presents new HIF-2α inhibitors for cancer

Medshine Discovery Inc. has divulged hypoxia inducible factor 2α (HIF-2α; EPAS1) inhibitors reported to be useful for the treatment of cancer. Read More

Therapyx’s Fapxil awarded US orphan drug designation for familial adenomatous polyposis

Therapyx Inc.’s Fapxil has been awarded orphan drug designation by the FDA for the treatment of familial adenomatous polyposis (FAP). Read More
Mantle cell lymphoma

Lantern’s LP-284 cleared by FDA to enter clinic for NHL

Lantern Pharma Inc. has received FDA clearance of its IND application for LP-284, being developed for the treatment of relapsed or refractory non-Hodgkin lymphoma (NHL), including mantle cell lymphoma, double hit lymphoma and other high-grade B-cell lymphomas. Enrollment in a first-in-human phase I trial is expected to begin during the fourth quarter of this year.  Read More

Chinese researchers discover new TYK2 inhibitors

Ennovabio (Zhejiang) Pharmaceuticals Co. Ltd. and Shanghai Ennova Biopharmaceutical Co. Ltd. have described 5-membered and 6-membered heterocyclic compounds acting as non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of cancer, viral infection, transplant rejection, cardiovascular and inflammatory disorders, and autoimmune, myeloproliferative and metabolic diseases. Read More

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