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Home » Newsletters » BioWorld Science

BioWorld Science

Feb. 28, 2024

View Archived Issues
Brush scrubbing brain figurine with soap

Studies bring insights into brain’s self-cleaning mechanisms

Separate teams of investigators have reported new insights into how the brain disposes of metabolic waste via the glia-based lymphatic system, or glymph system. In two papers published in Nature on Feb. 28, 2024, scientists from Washington University in St. Louis described how in sleeping animals, the synchronized activity of neurons drove ionic gradients that facilitated the movement of fluid through brain tissue. And researchers from the Massachusetts Institute of Technology showed that, in a mouse model of Alzheimer’s disease (AD), the glymphatic system mediated clearance of amyloid-β after sensory stimulation at a 40-Hertz rhythm. Read More

NEK1 found to drive tumor growth due to impaired immune signaling

Researchers have identified NIMA-related kinase 1 (NEK1) as a potential therapeutic target driving tumor growth. It was identified using Turbine Ltd.’s Simulated Cell platform when they simulated perturbations in the DNA damage response pathways. NEK1 is involved in DNA damage response, cell cycle and mitosis. Read More
colon-cancer-cell.png

Pharos Ibio’s pan-RAF inhibitor overcomes resistances in colorectal cancer treatment

Mutations in both KRAS and BRAF oncogenes, which are frequently found in colorectal cancer, are associated with poor prognosis and treatment resistance. Read More
Skin, tissue layer illustration

Derm-Biome to begin IND-enabling studies with DB-007-4 for inflammatory skin diseases

Derm-Biome Pharmaceuticals Inc. is preparing to initiate IND-enabling studies with DB-007-4, a first-line topical treatment for inflammatory skin diseases, such as acne, atopic dermatitis and rosacea. The company will shortly begin a GLP toxicology study. Read More
DNA with bar chart

Explore BioWorld’s comprehensive infographics collection

Discover a wealth of industry insights with BioWorld’s extensive collection of infographics, covering the latest trends and developments in both biopharma and med-tech. Our weekly infographics are curated to provide concise summaries of key topics: financings (IPOs, private financings, public/other and follow-on offerings), deals and M&As (top deals, and monthly value and volume), regulatory (including U.S. FDA and worldwide approvals), clinical trials and more. In addition, you’ll find access to BioWorld’s year-in-review reports, as well as special infographics about obesity, pain and addiction, biosimilars and the aging space. Read More
Brain-genetics.png

New gene therapy targets 14-3-3θ-mediated TDP-43 pathology in ALS and FTD

Researchers from Macquarie University have detailed the discovery of a novel gene therapy vector targeting pathological TAR-binding protein 43 (TDP-43), CTx-1000, as a potential therapeutic candidate for the treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) – two diseases characterized by cytoplasmic deposition of the nuclear TDP-43. Read More

Study reveals key role of RAR-α in averting kidney injury and fibrosis

Chronic kidney disease (CKD), characterized by a progressive decline in kidney function, affects over 13% of the global population. Read More

Iambic Therapeutics patents new CDK inhibitors for ovarian and breast cancer

Iambic Therapeutics Inc. has disclosed quinazoline compounds acting as cyclin-dependent kinase (CDK) inhibitors, particularly CDK2 and/or CDK4 and/or CDK6 inhibitors reported to be useful for the treatment of ovarian and breast cancer. Read More
3D cross-section illustration of muscle anatomy

Arthex’s ATX-01 receives FDA clearance for first-in-human study in myotonic dystrophy type 1

Arthex Biotech SL has received FDA clearance to initiate the phase I/IIa Arthemir study of ATX-01 for the treatment of myotonic dystrophy type 1 (DM1). Read More

POLQ tied to olaparib resistance in prostate cancer, study finds

PARP inhibitors such as olaparib are used for the treatment of metastatic castration-resistant prostate cancer (mCRPC) harboring homologous recombination deficiency (HRD), but a proportion of these patients do not respond to therapy or eventually develop resistance. Read More

Arvinas Operations divulges new TYK2 degradation inducers

Arvinas Operations Inc. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN)-binding moiety covalently linked to a non-receptor tyrosine-protein kinase TYK2-targeting moiety via linker. Read More
Eye, DNA double helix illustration.

Pulsesight Therapeutics launches to develop non-viral gene therapies for retinal diseases

Pulsesight Therapeutics SAS has launched with seed financing, with the aim of developing disruptive non-viral gene therapies with minimally invasive delivery technology. Read More

US researchers describe new GABA(A) receptor positive allosteric modulators for GI disorders

Scientists at Johns Hopkins University and The Lieber Institute for Brain Development have identified peripherally restricted GABA(A) receptor subunits α3β2γ2S (GABRA3) positive allosteric modulators reported to be useful for the treatment of inflammatory bowel disease, lactose intolerance and abdominal pain. Read More

Heptares Therapeutics presents new prostaglandin EP4 agonists for gastrointestinal and respiratory disorders

Heptares Therapeutics Ltd. has divulged pyrrolidine-2-carboxamide derivatives and morpholine-3-carboxamide derivatives acting as prostaglandin E2 receptor EP4 subtype (PTGER4; EP4) agonists reported to be useful for the treatment of gastrointestinal and respiratory disorders. Read More
CAR T cell with implanted gene strand

Murine model recapitulates CAR T-cell therapy-induced ICANS

Cancer patients receiving CAR T-cell therapy may develop and adverse event known as immune effector cell-associated neurotoxicity syndrome (ICANS). Read More

Hangzhou Zhongmei Huadong Pharmaceutical discovers new GTPase KRAS inhibitors for cancer

Hangzhou Zhongmei Huadong Pharmaceutical Co. Ltd. has described GTPase KRAS (G12D mutant) inhibitors reported to be useful for the treatment of cancer. Read More

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