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Home » Newsletters » BioWorld Science

BioWorld Science

April 3, 2024

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AI-generated illustration showing a brain in an hour glass with most of the sand at the bottom

Aging, and aging well, gives clues for dementia drug discovery

Ironically, the first person to be diagnosed with what is now Alzheimer’s disease was missing its major risk factor. When she first began showing symptoms of dementia in 1901, Auguste Deter was not particularly old. Despite Deter’s case, aging is the largest risk factor for developing Alzheimer’s, by a large margin. But “geroscience has not been translated into drugs for Alzheimer’s disease,” Howard Fillit, Alzheimer’s Drug Discovery Foundation co-founder and chief scientific officer, told BioWorld. “We’re just starting to see that cross-fertilization now.” This first article of a three-part BioWorld series on Alzheimer’s disease looks at how a group of researchers, as well as some startups, are trying to approach Alzheimer’s via an aging lens. Read More

RAM-2061 shows initial preclinical efficacy for multiple myeloma-associated bone disease

About 90% of patients with multiple myeloma (MM) develop severe bone disease, known as myeloma bone disease (MBD). This occurs due to the ability of MM cells to disrupt bone homeostasis, leading to excessive bone resorption. Some current treatments are effective for treating MBD, but they are associated with undesired adverse events. Read More
PAD-artery-plaque.png

Repair Biotechnologies’ LNP/mRNA therapy reverses atherosclerosis progression in mouse models

Repair Biotechnologies Inc. has reported new data showing that its lipid nanoparticle (LNP)/messenger RNA (mRNA) therapy rapidly reversed the progression of atherosclerosis in mouse models applicable to familial hypercholesterolemia as well as atherosclerosis in the broader population. Read More
3D illustration of T cells fighting cancer

Ipsen nominates drug candidate from Marengo partnership

Ipsen has nominated the first clinical drug candidate from its multiyear strategic partnership with Marengo Therapeutics Inc. in oncology. Read More

Discovery of AM-4085, an orally bioavailable FmlH lectin antagonist for the treatment of UTIs

FmlH is a bacterial adhesin of uropathogenic E. coli (UPEC) that has been shown to be up-regulated during chronic UPEC infection. Washington University scientists recently disclosed the discovery and preclinical evaluation of novel FmlH lectin antagonists as potential candidates for the treatment of chronic urinary tract infections (UTIs) and kidney infections. Read More
Illustration of human papillomavirus (HPV) infection

mRNA vaccine could prevent and treat HPV-related cancer

A group of scientists at Shanghai Virogin Biotech Co. and Zhujiang Hospital in China designed a new mRNA vaccine that could prevent tumor formation associated with human papillomavirus 16 (HPV16) and also reduce its size if used as a treatment. Read More

Tibet Haisco Pharmaceutical patents new antagonists of LPAM-1 and VLA-4 for inflammatory disorders

Tibet Haisco Pharmaceutical Co. Ltd. has disclosed integrin α4β7 (LPAM-1) and/or α4β1 (ITGA4; VLA-4) antagonists reported to be useful for the treatment of inflammatory disorders. Read More
Female sitting on floor in dark room

Mira targets year-end IND submission for oral ketamine analogue

Mira Pharmaceuticals Inc. has offered an update on the ongoing preclinical studies of Ketamir-2. Read More

Evaxion’s EVX-B1 vaccine antigens reduce S. aureus bacterial burden in surgical site infection model

Evaxion Biotech A/S and a collaborator have successfully concluded a series of large nonrodent animal infection studies testing antigens from Evaxion’s preclinical EVX-B1 vaccine candidate against Staphylococcus aureus. The EVX-B1 antigens were shown to significantly reduce disease burden. Read More

Chiesi Farmaceutici divulges new JAK inhibitors for respiratory disorders

Chiesi Farmaceutici SpA has synthesized heterocyclic derivatives acting as Janus kinase (JAK) inhibitors reported to be useful for the treatment of acute lung injury, asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Read More
Cancer tumor in breast illustration

Blueprint Medicines presents further preclinical data and structure of BLU-222

Blueprint Medicines Corp. recently disclosed the chemical structure of BLU-222, an oral, potent and highly selective inhibitor of the CDK2 kinase, being developed for the potential treatment of cancers with CCNE1 amplification and/or cyclin E overexpression, such as HR-positive HER2-negative breast cancer resistant to CDK4/6 inhibitor therapy. Read More

Halda Therapeutics describes new heterobifunctional compounds for cancer

Halda Therapeutics LLC has identified heterobifunctional compounds reported to be useful for the treatment of cancer. Read More

Alterome Therapeutics presents new AKT1 inhibitors

Alterome Therapeutics Inc. has divulged RAC-α serine/threonine-protein kinase (AKT1; PKBα) (E17K mutant) inhibitors reported to be useful for the treatment of cancer. Read More
Drug R&D concept image.

Researchers uncover MYC’s role in CDK4/6 inhibitor resistance and identify a MYC-degrading molecule

The cyclin-dependent kinases CDK4 and CDK6 are crucial for cell cycle progression and, therefore, considered potential targets for cancer therapy. Read More

Exscientia discovers new NLRP3 inflammasome inhibitors

Exscientia plc has described NLRP3 inflammasome inhibitors reported to be useful for the treatment of atherosclerosis, autoimmune disease, cancer, gout, inflammatory and neurological disorders, psoriasis and sickle cell disease. Read More

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