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Home » Newsletters » BioWorld Science

BioWorld Science

Aug. 5, 2024

View Archived Issues
cancer-cell-light.png

Forcing tumor cells to get with the re-program

Cellular immunotherapy is the Lamine Yamal of cancer therapy. It is easy to forget how young the field is – and that as stunning as it is to watch in action already, it is still reaching its full potential. One aspect of doing so is working in a broader range of tumor types. The field made a giant step toward that goal with last week’s approval of Tecelra (afamitresgene autoleucel, Adaptimmune Therapeutics plc), the first CAR T cell to be approved for treatment of a solid tumor. Read More

WIZ glue degrader restores fetal hemoglobin

Scientists at the Novartis Institutes for Biomedical Research (NIBR) in Cambridge have discovered a small molecule that could be used as a therapy for sickle cell disease (SCD). The molecular glue oral degraders of the WIZ transcription factor called dWIZ-1 and dWIZ-2, bind to cereblon (CRBN) and WIZ, marking it for degradation and inducing the expression of fetal hemoglobin (HbF). Read More
Streptococcus pyogenes before and after treatment

PS-757 fights flesh-eating bacteria, biofilm

Investigators at Washington University in St. Louis and Umea University have reported that the small molecule PS-757 was effective in culture and animal models against Streptococcus pyogenes, a gram-positive pathogen responsible for more than 500,000 deaths per year globally. Read More
Illustration of tumor in the liver

Dual-target inhibitor shows activity and safety in models of liver cancer

Researchers from Changzhi Medical College and affiliated organizations presented the discovery of DYC-1, a novel dual-target inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) and histone deacetylase 8 (HDAC8), being developed for the treatment of hepatocellular carcinoma (HCC). Read More

The University of Florida describes new PPARγ agonists

The University of Florida has prepared and tested PPARγ agonists reported to be useful for the treatment of diabetes, hyperparathyroidism, metabolic syndrome, multiple myeloma, nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH), obesity, osteoporosis and Paget disease, among others. Read More
Illustration of diseased kidney

Latent TGF-β1 complex inhibitor avoids renal fibrosis

An antibody that binds to the latent form of transforming growth factor-β1 (TGF-β1) prevented its release into the extracellular matrix and reduced the progression of fibrosis in the kidney. TGF-β is synthesized and secreted into the extracellular matrix in a latent inactive form associated with the latency peptide. Read More

‘We're always on the lookout for what's next’

From no hope to viable treatments, BioWorld  is there to cover the breakthroughs in medicine. Listen to Randy Osborne explain why the BioWorld  team is ‘always on the lookout for what's next.’ Read More
Antibodies attacking cancer cell

Salubris gets EMA clearance for basket trial

Salubris Biotherapeutics Inc. has received clearance by the European Medicines Agency (EMA) to begin a first-in-human basket trial of JK-06. Read More

Angel Pharmaceuticals presents new PARP-7 inhibitors

Angel Pharmaceuticals Co. Ltd. has described protein mono-ADP-ribosyltransferase TIPARP (PARP-7; ARTD14) inhibitors reported to be useful for the treatment of cancer. Read More

IFM Due identifies mutant-selective EGFR inhibitors

IFM Due Inc. has disclosed EGFR (HER1; erbB1) mutant inhibitors reported to be useful for the treatment of cancer. Read More
Dollar sign inside vial, syringe

Anivive receives grant funding for antifungal vaccine

Anivive Lifesciences Inc., a One Health technology company, reported the NIH’S National Institute of Allergy and Infectious Diseases (NIAID) has awarded grant funding worth up to $33 million to the company to support the development of a vaccine against the fungus Coccidioides, which causes Valley Fever. Read More

Incyte divulges heteroaryl fluoroalkenes as DGK inhibitors

Incyte Corp. has synthesized diacylglycerol kinase α (DGK-α) and/or diacylglycerol kinase ζ (DGK-ζ) inhibitors reported to be useful for the treatment of cancer. Read More

US HHS files patent for prodrugs to treat or prevent HIV-1

The U.S. Department of Health and Human Services has discovered viral maturation inhibitors and their prodrugs reported to be useful for the treatment of HIV infection. Read More
Test-tubes_dropper.png

Preclinical analysis to optimize dosing regimens for ATM inhibitor WSD-0628

Researchers from Wayshine Biopharm Holding Ltd. published new data regarding the preclinical systemic pharmacokinetics (PK), dose proportionality, and central nervous system (CNS) distribution of the novel ataxia telangiectasia mutated (ATM) inhibitor WSD-0628, being developed for the treatment of brain tumors. Read More

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