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Home » Newsletters » BioWorld Science

BioWorld Science

Jan. 3, 2025

View Archived Issues
Elderly hands holding broken brain structure

Zhongzhi drops $3M in Gabaeron series A for stem cell AD therapy

Zhongzhi Pharmaceutical Holdings Ltd. made a $3 million investment in a series A financing round of stem cell therapy developer Gabaeron Inc. Dec. 21, expected to help propel Gabaeron’s preclinical Alzheimer’s disease (AD) candidate into phase I testing. Read More

New carbapenemase identified in C. freundii raises resistance concerns

In a recently published study, researchers based at Université Paris-Saclay identified OXA-1186, a novel carbapenemase related to the previously known OXA-198 enzyme, in a clinical isolate of Citrobacter freundii. This discovery underscores the ongoing challenge of antibiotic resistance in bacterial pathogens. Read More
Female researcher wearing mask and safety glasses holding dropper

Institut Pasteur Korea and POSTECH institutes to collaborate on infectious disease research

Institut Pasteur Korea has signed a memorandum of understanding (MOU) with four Pohang University of Science and Technology (POSTECH)-affiliated research institutes with the aim of pursuing joint research on mRNA vaccine and treatment development. Read More
Antibiotic resistant bacteria inside a biofilm

The diarylquinoline TBAJ-587 shows potential against M. abscessus infections

A recent study by scientists at Tongji University highlights the potential of TBAJ-587, a novel diarylquinoline, in addressing the challenge of treating Mycobacterium abscessus infections, a subset of nontuberculous mycobacteria that exhibit resistance to many antibiotics. Read More
2024 on teal background

2024 BioWorld Science Year in Review

Taking a look back at the achievements in research this year, including brain maps, pandemic breakthroughs and advances in pregnancy health. Read More

Holiday notice

In accordance with the publishing schedule, BioWorld Science will not be published on Monday, Jan. 6, 2025. Read More
Lung cancer illustration

Exploring DX2 inhibition as a therapeutic strategy in nicotine-related lung cancer

Small-cell lung cancer accounts for about 10%-15% of all lung cancers, yet its molecular pathogenesis remains largely unexplored due to its rapid progression and a scarcity of surgical specimens. Read More

PARP1-PROTAC and BRD4 inhibitors synergize in pancreatic cancer treatment

Pancreatic cancer is a highly lethal digestive malignancy with a 5-year survival rate of 10%. So far, the available therapeutic strategies are scarce and the few advancements made, as is the case of poly(ADP-ribose) polymerase (PARP) inhibitors, are only effective in 5% to 7% of patients. Investigators at the Third People’s Hospital of Chengdu and collaborators described the synergistic effect obtained by the combined administration of LB-23, a PARP1 degrader, and JQ1, a BRD4 inhibitor, in homologous recombination (HR)-proficient pancreatic cancer models. Read More
Structural model of dengue virus.

In vivo morpholino oligomers targeting the 3′ untranslated region show efficacy against dengue virus

The dengue virus (DENV) is a single-stranded RNA virus with increasing worldwide prevalence causing severe mosquito-borne viral infections. Therefore, effective strategies to prevent and treat DENV infections are urgently needed. Read More

Huiyu scientists patent new SOS1 inhibitors

Scientists at Sichuan Huiyu Pharmaceutical Co. Ltd. and Sichuan Huiyu Seacross Pharma Technology Ltd. have disclosed pyridazinopyridone derivatives acting as son of sevenless homolog 1 (SOS1) inhibitors. As such, they are reported to be useful for the treatment of cancer, gingival fibromatosis, cardiofaciocutaneous and Noonan syndromes. Read More

Gluetacs Therapeutics divulges new EGFR degradation inducers

Gluetacs Therapeutics (Shanghai) Co. Ltd. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety covalently linked to a target protein binding moiety through a linker reported to be useful for the treatment of cancer, dermatological, neurological, respiratory and cardiovascular disorders, autoimmune diseases, infections and transplant rejection, among others. Read More
Staphylococcus-aureus-staph-bacteria-infection.png

New selective and potent ClpP agonist effectively targets S. aureus, including MRSA

Caseinolytic protease P (ClpP) is a conserved serine protease present in both bacteria and humans, essential for maintaining protein quality by degrading misfolded proteins. Read More

Chinese scientists describe new KIF18A inhibitors

Researchers at Shanghai Aryl Pharmtech Co. Ltd. and Zhejiang Hisun Pharmaceutical Co. Ltd. have identified aromatic amide derivatives acting as kinesin-like protein KIF18A inhibitors reported to be useful for the treatment of cancer. Read More

CDK2/cyclin E1 inhibitors disclosed in Incyte patent

Incyte Corp. has divulged CDK2/cyclin E1 inhibitors reported to be useful for the treatment of cancer. Read More
3D illustration of tumor

Intratumoral mRNA encoding TLR2/6 agonist enhances innate and adaptive antitumor responses

Toll-like receptors (TLRs) are crucial to trigger anticancer immune responses. Despite the promise of TLR agonists as potential anticancer agents, few have reached the clinics due to concerns related to cytokine release syndrome and limited efficacy. Read More

Boehringer and Vanderbilt scientists discover new GTPase KRAS inhibitors

Scientists at Boehringer Ingelheim Pharma GmbH & Co. KG and Vanderbilt University have described GTPase KRAS and/or its mutant inhibitors reported to be useful for the treatment of cancer. Read More

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