Company*
(Country; Symbol)

University/
Nonprofit@

Type Of Agreement

Product Area

Details (Date)


Ablynx NV*
(Belgium)

National Research Council of Canada

Collaboration

The work focuses on Nanobodies developed at the NRC that cross the blood-brain barrier

They plan to develop drugs and diagnostics for central nervous system diseases, initially Alzheimer's disease; terms were not disclosed (5/26)

Acambis plc
(UK; ACAM)

Flanders Interuniversity Institute for Biotechnology (Belgium)

Collaboration

To develop a vaccine against both the A and B strains of influenza

The goal is to generate a candidate that would protect against both strains, and would not require annual formulation changes (8/4)

Advanced Cell
Technology Inc.
(OTC BB:ACTC)

The Burnham Institute

Collaboration

For research that aims to isolate stem cell- specific differentiation markers

They will use particle display technology to identify markers for many of the lineages of cells that make up the human body (7/27)

Amplimed
Corp.*

University of Arizona

License agreement

Amplimed got rights to a porfolio of compounds, including the cancer agent FB642

A university-related company gets equity in Amplimed, along with potential milestone and royalty payments (8/9)

Affymetrix
Inc.
(AFFX)

Broad Institute of MIT and Harvard

Agreement

The institute will use the GeneChip Mapping 500K Set for genome-wide association studies

The institute gained use under Affymetrix's early access program; the institute and collaborators intend to generate genotypes relevant to multiple diseases (7/21)

Akubio Ltd.*
(UK)

U.S. Army

Collaboration

To develop improved systems for detecting bioterrorism agents

The work will be done with the U.S. Army Medical Research Institute of Infectious Diseases and is being supported by $3M from the National Institute of Allergy and Infectious Diseases (5/17)#

Albany
Molecular
Research Inc.
(AMRI)

National Institute of Neurological Disorders and Stroke

Collaboration

Two-year deal aimed at developing treatments for spinal muscular atrophy

AMRI will provide medicinal chemistry services on a fee-for- services basis(7/11)

Alnylam
Pharmaceuticals
Inc.
(ALNY)

Max Planck Society (Germany)

License amendment

Amended deal reinforces Alnylam's exclusivity for the "Tuschl II" patent application

The patent is one believed by the company to be fundamental for RNA interference; Alnylam will issue 270,000 shares to Max Planck and other co- wners of the technology (6/16)

Alnylam
Pharmaceuticals
Inc.
(ALNY)

University of Georgia

Collaboration

To discover and develop RNAi-based therapeutics for newly emerging strains of influenza virus

Alnylam intends to discover siRNAs that target flu genes required for viral replication and have antiviral activity; terms of the deal were not disclosed(6/25)

Ambion Inc.*

MitoChek consortium

Agreement

Ambion will provide the consortium a genome-wide siRNA library targeting every human gene

The European Union-funded consortium will use the library to research how cell division is regulated; terms of the deal were not disclosed (8/12)

Applied
Biosystems
Group
(NYSE:ABI)

National Institute of Genomic Medicine of Mexico

Collaboration

To establish an Applied Biosystems sequencing and genotyping unit at the institute

They also will conduct research studies focused on health issues important to the Mexican population (7/25)

Applied Imaging
Corp.
(AICX)

University of Vermont

Collaboration

To further develop and validate technology to detect and characterize circulating tumor cells in the blood

Applied Imaging subsidiary CTC Inc. will work with the university in the deal, terms of which were not disclosed (5/26)

Arrowhead
Research Corp.
(ARWR)

Stanford University

License agreement

Arrowhead licensed a nanotech device designed to control the behavior of adult stem cells

Arrowhead will fund additional research on the device in exchange for the right to exclusively license the technology (6/6)

Artemis
Pharmaceuticals
GmbH*
(Germany)

Max Delbruk Center for Molecular Medicine and the University of Wurzbur (both in Germany)

Collaboration

Three-year deal to develop and validate methods for the functional analysis of disease- related genes in transgenic rats

The work will be jointly funded by Artemis and the RiNA RNA- Network; Artemis gets rights to resulting products through a license agreement with RiNA GmbH, an entity of the German government (7/19)

Ascentia
Biomedical Corp.
(OTC BB:ASCE)

University of Washington

Option agreement

Ascentia got rights to a family of compounds potentially applicable to a number of diseases

Terms of the option were not disclosed; the compounds are being developed for cancer, sepsis, autoimmune diseases and for use in vaccines (8/15)

Avantogen
Ltd.
(Australia;
ASX:ACU)

University of Alabama at Birmingham

Collaboration

For preclinical studies of a vaccine for herpes simplex virus type 2

UAB will use the firm's GP1-0100 adjuvant with a live, attenuated HSV-2 vaccine candidate (6/7)

BioCurex Inc.*
(PK:BOCX)

Center for Cancer Care

Collaboration

Deal to develop and evaluate BioCurex's RECAF technology

The technology is used in targeting cancer cells; terms of the deal were not disclosed (5/20)

BioLineRx
Ltd.*
(Israel)

Weizmann Institute of Science (Israel)

License agreement

BioLineRx licensed BL-2040, a small-molecule drug candidate

The compound may have applications in treating hypertension, obesity and metabolic syndrome; terms were not disclosed (6/20)

Biolog Inc.* and
Axiohelix*
(Japan)

NARA Institute (Japan)

Collaboration

They extended deal to phenotype and determine the function of each gene in the E. coli genome

Work on the project began in November 2004; terms of the deal were not disclosed (7/26)

BioSante
Pharmaceuticals
Inc.
(AMEX:BPA)

Wake Forest University and Cedars Sinai Medical Center

License agreement

BioSante exercised its option to license triple-hormone contraception technology

The technology covers combinations of estrogens and progestins with androgens; BioSante will make up- ront and maintenanace payments, along with potential milestones and royalties (8/10)

Biosite Inc.
(BSTE)

Johannes Gutenberg University (Germany)

License agreement

Biosite got exclusive rights to caspase-1, a potential biomarker for cardiovascular disease

Biosite is collaborating with the University of Mainz to investigate clinical applications; terms of the deal were not disclosed (8/22)

Biosite Inc. BSTE)

Cincinnati Children's Hospital Medical Center and Columbia University

License agreement

Biosite got rights to neutrophil gelatinase- associated lipocalin, a potential for identifying acute renal failure

Biosite will make antibodies to NGAL; the NGAL immunoassay then will be tested on blood samples to assess its potential; terms biomarker of the exclusive license agreement were not disclosed (7/13)

BioVeris Corp.
(BIOV)

University of Massachusetts at Amherst

Option agreement

BioVeris optioned rights to a vaccine candidate for Chlamydia

Separately, BioVeris will sponsor up to $600,000 of research on the candidate at UMA through 2006; if optioned, UMA would get license fees and potential milestones and royalties (5/25)

Biovitrum AB*
(Sweden)

Karolinska Institute (Sweden)

Agreement

Biovitrum will produce a protein for preclinical research based on a technique developed at the institute

Biovitrum, on behalf of the Department of Woman and Child Health, will produce recombinant HMGB-1, which is implicated in inflammatory reactions (5/31)

Cambria
Biosciences LLC*

Northwestern University

Collaboration

To screen existing compounds for activity againstamyotrophic lateral sclerosis

The work is being funded by a grant from the ALS Association (8/8)

Catalyst
Biosciences
Inc.*

Torrey Pines Institute for Molecular Studies

License agreement

Catalyst got rights to use technology for protease engineering, selection and optimization

The license covers a protease selection technology, and solidifies and expands Catalyst's position in proteases (7/25)

Cenix
BioScience
GmbH*
(Germany)

Instituto de Medicina Molecular (Portugal)

Collaboration

They intend to identify human genes required for the malaria infection process

The work, using an vitro assay system at the institute, is being funded by European agencies (6/29)

ChemDiv Inc.*

Scripps Florida

Collaboration

They extended deal giving Scripps access to ChemDiv screening libraries

Terms of the deal were not disclosed (7/21)

Chlorogen Inc.*

Rutgers University

License agreement

Chlorogen got exclusive rights to chloroplast transformation patents

The deal also gives Chlorogen limited rights to certain future discoveries by Rutgers from research in the field (8/16)

ChondroGene
Ltd.
(Canada;
TSE:CDG)

University of California at San Francisco

Alliance

Deal setting framework for collaborations applying the Sentinel Principle to new drugs and diagnostics

The Sentinel Principle is the company's approach to detect and stage diseases or conditions from a blood sample; Chrondro- Gene would have rights or options to resulting products (8/10)

ChondroGene
Ltd.
(Canada;
TSE:CDG)

Lam Wa EE Hospital and Island Hospital (both in Malaysia)

Collaborations

The hospitals will provide clinical samples in a variety of disease areas

The hospitals eventually will offer their patients molecular diagnostic tests and services from ChondroGene (6/10)

Ciphergen
Biosystems
Inc.
(CIPH)

University of Kentucky

Collaboration

Ciphergen got exclusive rights to license discoveries; the focus is on ovarian cancer

Ciphergen will provide its suite of proteomic solutions for biomarker discovery and development of assays to the effort; terms were not disclosed (8/24)

CombiMatrix
Group
(CBMX)

Biodesign Institute at Arizona State University

Collaboration

To develop a peptide array synthesizer using CombiMatrix's virtual- flask technology

The institute is purchasing CombiMatrix equipment and funding development; any revenues would be shared (8/12)

Corautus
Genetics Inc.
(VEGF)

Caritas St. Elizabeth's Medical Center

Agreement

Corautus will provide its VEGF-2 product for evaluation in a Phase I trial in diabetic neuropathy

Corautus would get rights in that indication; also, Corautus licensed certain technology, including the use of angiogenic growth factors in peripheral neuropathy; the center is entitled to up- ront, milestone and royalty payments (8/10)

Crucell NV
(the Netherlands;
CRXL)

Naval Medical Research Center of the U.S. Navy

Cooperative Research and Development Agreement

To construct AdVac- based vaccines against anthrax and plague and test them in nonhuman primates

Crucell got an option for exclusive rights to any vaccine that may result from the deal (8/17)

Cytheris*
(France)

New York University, the City University of New York and the Aaron Diamond AIDs Research Center

License agreement

Cytheris got rights to a family of immuno-modulating agents that activate NKT and dendritic cells

Terms of the exclusive, worldwide deal were not disclosed (5/23)

CytoGenix
Inc.
(OTC
BB:CYGX)

Imperial College London

Collaboration

For research studies using the company's antimicrobial nucleic acid compound

College researchers will further elucidate the antimicrobial activity of CytoGenix's RBL-1 compound (8/9)

CytoGenix
Inc.
(OTC
BB:CYGX)

University of Pennsylvania

Agreement

The university will perform animal studies for the company

The tests will use the company's synDNA technology to test a DNA vaccine against smallpox (6/21)

CytoGenix
Inc.
(OTC BB:CYGX)

National Institutes of Health

Evaluation license

CytoGenix will conduct experiments using an HIV DNA vaccine

The synthetic vaccine is derived from HIV gene sequences contained in an NIH plasmid; terms were not disclosed (5/25)

Digene Corp.
(DIGE)

Georgetown University

Settlement and license agreement

They settled litigation relating to patents covering human papillomavirus

Georgetown will get payments totaling $7.5M, and royalties on sales of 5% to 6% (7/14)

Diversa
Corp.
(DVSA)

Clemson University

Collaboration

To assess opportunities for Diversa enzymes in enhancing human nutrition

The intitial focus is on evaluating the ability of protein supplements to improve stamina and alertness and reduce fatigue (6/2)

DOR
BioPharma Inc.
(AMEX:DOR) and
Cambrex Corp.

SRI International

Collaboration

SRI is assisting in the development of the recombinant ricin vaccine RiVax

SRI will optimize the immune response to the vaccine and perform preclinical safety testing; terms were not disclosed (7/5)

Duska
Therapeutics
Inc.
(OTC BB:DSKT)

Undisclosed European scientists

License agreement

Duska got exclusive rights to P2 receptor-based technology not disclosed (6/15)

The technology is expected to have applicability in treating glaucoma; terms of the deal were

Duska
Therapeutics
Inc.
(OTC BB:DSKT)

University of Pennsylvania

Agreement

Preclinical studies with ATPotent will be carried out at the university

ATPotent, a liquid formulation of adenosine 5'-triphosphate, is being developed by Duska for treating male infertility (6/13)

Enzo Biochem
Inc.
(NYSE:ENZ)

Ludwig Maximilians University (Germany)

Acquisition

Enzo acquired rights to a candidate drug and technology for use in the treatment of uveitis

The drug, which has orphan status in Europe, has been in a small Phase I trial in Germany; terms of the deal were not disclosed (6/9)

Galapagos NV
(Belgium; Euronext:
GLPG)

High Q Foundation Inc.

Collaboration

Two-year deal to discover targets and develop drugs for Huntington's disease

Galapagos may receive up to $3M in the deal, and has the option to further develop certain targets identified (8/12)

Galapagos NV
(Belgium; Euronext:
GLPG)

Leiden University (the Netherlands)

Collaboration

To pursue a small-molecule drug discovery program in arthritis

The four-way collaboration also includes ZoBio BV and Pyxis Discovery BV (8/10)

GeneGo Inc.*

National Cancer Institute

License agreement

The NCI licensed GeneGo's MetaCore 2.5 platform

The platform is used to mine high- throughput experimental data; terms were not disclosed (5/31)

GenoMed Inc.
(PK:GMED)

International Disease Management Alliance

Agreement

GenoMed joined the alliance, which was formed to promote disease management

Details on GenoMed's role in the alliance were not disclosed (7/13)

Genospectra
Inc.*

CRNS (France)

Agreement

To develop a panel of optimized delivery reagents

Genospectra also gets an exclusive license to "MPG" technology developed at the CNRS, and to products resulting from the collaboration (7/19)

Gilead Sciences
Inc.
(GILD) and
Royalty Pharma

Emory University

Agreement

Gilead and Royalty purchased Emory's royalty interest in the HIV drug emtricitabine (Emtriva)

Emory got a one-time cash payment of $525M, with 65% of it coming from Gilead; Gilead is obligated to pay royalties on future sales to Royalty Pharma (7/18)

Immunetrics
Inc.*

University of Cologne (Germany) and the Ludwig Boltzmann Institute (Austria)

Collaboration

To discover biomarkers of inflammation for use in drug discovery and disease diagnosis and management

The academic partners get access to Immunetrics' modeling platform; the universities are providing a database of human and animal data (6/6)

InforSense
Ltd.*
(UK)

National Cancer Institute

Agreement

The NCI will use the company's technology for high-throughput genetic data analysis

The NCI will use the KDE Infor- Sense integrative analytics platform under a five-year deal; terms were not disclosed (8/30)

Insilico
GmbH*
(Austria)

German Resource Center for Genome Research

Collaborattion

To integrate various information for the use of research scientists

The effort links the company's MASI database with the center's material index (6/1)

IntegraGen
SA*
(France)

Fondation Autisme (France)

Agreement

IntegraGen will use DNA samples collected by the foundation to validate its genetic test for autism

IntegraGen is supporting the foundation with a donation and by helping to create a databank and repository of DNA samples (5/23)

Intercell AG
(Austria; VSE:ICLL)
and Statens Serum
Institut (Denmark)

Aeras Global TB Vaccine Foundation

Agreement

Aeras will fund development of a prophylactic tuberculosis vaccine

In return, Aeras will get a sublicense to the vaccine for a number of developing countries; SSI and Intercell retain rights elsewhere (6/27)

Invitrogen
Corp.
(IVGN)

The Scripps Research Institute

Collaboration

To develop improved methods for expression, isolation and character- ization of membrane proteins

Invitrogen will have the right to commercialize resulting technologies (8/25)

JPT Peptide
Technologies
GmbH*
(Germany)

Oregon Health & Science University

Collaboration

Deal to discover T-cell epitopes to accelerate the development of tuberculosis vaccines

JPT, a subsidiary of Jerini AG, will apply its high-throughput peptide synthesis and screening platform in the effort (7/7)

Kalypsys Inc.*

The Scripps Research Institute

Agreement

Scripps will access Kalypsys' ultra-high- throughput screening technologies

The technology will be used in Scripps' newly created site in Florida; terms were not disclosed (6/15)

Lipid Sciences
Inc.
(LIPD)

Washington Hospital Center and MedStar Research Institute

Collaboration

To broaden the scope of the company's HDL therapy platform

The deal allows Lipid to expand the program into the area of HDL mimetic peptides; terms were not disclosed (8/25)

Maas BiolAB
LLC*

Walter Reed Army Institute of Research

Cooperative Research and Development Agreement

Deal to develop cyclosporin neuroprotection in indications relevant to military casualties and homeland security

They will further collaborate to develop Maas' cyclosporin formula NeuroSTAT in models of traumatic brain injury and nerve gas poisoning (7/12)

Macrogen Inc.*
(South Korea)

National Institute of Toxicological Research (South Korea)

Agreement

Macrogen will provide gene expression analysis services to the NITR

The services will use the Applied Biosystems Group Expression Array System; terms were not disclosed (8/9)

Meridian
Bioscience Inc.
(VIVO)

National Institutes of Health

License agreement

Meridian got rights to recombinant parvovirus B19 vaccine technology

The license went to Meridian subsidiary Viral Antigens Inc.; Meridian previously had a contract to manufacture the vaccine (7/7)

MerLion
Pharmaceuticals
Pte. Ltd.*
(Singapore)

Institute of Molecular and Cell Biology (Singapore)

Collaboration

Three-year deal to discover and develop cancer drugs; the initial focus is the Bcl-2 family of proteins

IMCB will provide certain drug targets and projects; MerLion will provide natural product sample collections, and apply screening and chemistry skills; they will share resulting ownership (7/1)

Mesoblast Ltd.
(Australia; ASX:MSB)

Colorado State University

Agreement

CSU will perform preclinical studies of Mesoblast technology

CSU will test universal stem cell technolgoy for bone regeneration under undisclosed terms (7/21)

MicroIslet Inc.
(AMEX:MII)

The Scripps Research Institute

Collaboration

They extended for two years work to develop islet cell transplantation therapies

The focus is on diabetes; Micro-Islet is providing financial support and technical assistance, and has the option to retain all commercial rights (8/31)

Millenium
Biologix Corp.
(Canada; TSE:MBC)

Massachusetts Institute of Technology

License agreement

Millenium got rights to technology for certain uses of growth factors

Millenium plans to develop a specific combination of growth factors in its Autologous Clinical Tissue Engineering Systems for cartilage repair (8/30)

NeoRx Corp.
(NERX)

Scripps Florida

Collaboration

To discover small-molecule protein kinase inhibitors as therapeutic agents

The goal is to identify potential cancer treatments (8/4)

Neuren
Pharmaceuticals
Ltd.
(Australia;
ASX:NEU)

Walter Reed Army Institute of Research

Expanded agreement

The deal is for development of Neuren's NNZ-2566 for traumatic brain injury

They will explore the use of Walter Reed's model for predicting clinical outcomes; Walter Reed will fund half of preclinical research; Neuren retains all rights outside the U.S. military (7/8)

New River
Pharmaceuticals
Inc.
(NRPH)

University of California at San Francisco

License agreement

New River got rights to an approach to improve the use of opioid analgesics by reducing tolerance development

UCSF's Ernest Gallo Clinic and Research Center is entitled to a license fee and potential milestone and royalty payments (7/8)

Nonlinear
Dynamics Ltd.*
(UK)

Australian Proteome Analysis Facility Ltd.

License agreement

The APAF purchased two licenses to the company's Progenesis Discovery v2005

The product is a 2-D gel image analysis platform; terms of the licenses were not disclosed (6/16)

Odyssey Thera
Inc.*

National Institutes of Health

Agreement

Odyssey gave the NIH access to human cell lines with PCA technology for screening biochemical pathways

Odyssey is providing access to the NIH Chemical Genomics Center as part of the NIH's Molec- ular Libraries Roadmap Initiative (8/17)

OriGene
Technologies
Inc.*

Massachusetts General Hospital

Collaboration

Deal to use OriGene's FlagArray platform for high- hroughput functional analysis of genes

Terms of the deal were not disclosed (7/25)

Orion Genomics
LLC*

Washington University

Collaborations

To discover biomarkers for use in development of tests for cancer

They will look for "Second Code" biomarkers for tests to screen for cancer at an early stage and to help guide treatment (8/9)

Orion Genomics
LLC*

Johns Hopkins University School of Medicine

Collaboration

To better understand the role of DNA's "Second Code" in colon cancer

They will study DNA methylation with the goal of developing a diagnostic test for the cancer's early detection (6/7)

Peregrine
Pharmaceuticals
Inc.
(PPHM)

U.S. Army Medical Research Institute of Infectious Diseases

Cooperative Research and Development Agreement

USAMRIID will study the potential of Tarvacin in treating hemorrhagic diseases

Peregrine will supply the anti- phospholipid therapy; it will be studied for hemorrhagic diseases resulting from Ebola and Marburg viral infections (7/21)

Perlegen
Sciences Inc.*

RIKEN (Japan)

Collaboration

They will use Affymetrix Inc. technology to conduct whole- enome association studies in Japan

The goal is to identify the genetic causes of up to 47 common diseases; Perlegen's subsidiary in Japan will work with RIKEN (7/20)

Perlegen
Sciences Inc.*

Pritzker Neuro- psychiatric Disorders Research Consortium

Collaboration

Perlegen is conducting a high- density whole-genome association study of bipolar disorder

Results of the work are expected to help diagnose and treat neuropsychiatric diseases; terms ofthe deal were not disclosed (7/14)

Perlegen
Sciences Inc.*

Women's Health Initiative

Collaboration

Deal to conduct a high-density whole- genome scan of single nucleotide polymorphisms

The SNPs will be in relation to coronary heart disease, stroke and breast cancer, and combined postmenopausal hormone therapy; work is being funded by the National Heart, Lung and Blood Institute (6/30)

Pharmacopeia
Drug Discovery
Inc.
(PCOP)

Columbia University and Cold Spring Harbor Laboratory

Amended license agreement

The deal covers the company's ECLiPS tagging technology

Pharmacopeia said it also resolved a prior dispute regarding payment of royalties under the initial deal; terms were not disclosed (5/26)

Phogen Ltd.
(UK; joint venture
of Xenova Ltd.)

Cancer Research Technology Ltd. (UK)

Agreement

CRT will help commercialize Phogen's VP22 technology

CRT will help identify partners and negotiate terms for the drug-delivery platform (8/1)

Power3 Medical
Products Inc.
(OTC BB:PWRM)

University of Texas M.D. Anderson Cancer Center

License
agreement

Power3 got rights to cancer technologies co-developed by the parties

The technologies involve an early detection test, protein bio-markers and targets for drug- resistant cancer (8/9)

Power3 Medical
Products Inc.
(OTC BB:PWRM)

The Methodist Hospital Research Institute

Agreement

To search for bio- markers and develop diagnostic tests for neurodegenerative diseases

The deal marks a continuation of work already under way between the parties; terms were not disclosed (7/19)

PPD Inc.
(PPDI)

Duke University

License agreement

Duke got rights to develop a portfolio of geranylgeranyl trans- ferase inhibitors

Duke will fund R&D, and would share equally with PPD any future payments by third parties (6/22)

Prolexys
Pharmaceuticals
Inc.*

Imperial College London

Agreement

Prolexys joined a consortium focused on developing drugs for treatment of latent tuberculosis infection

The consortium is supported by a $20M grant to Imperial College from the Grand Challenges in Global Health initiative (7/28)

Proteome
Systems Ltd.
(Australia; ASX:PXL)

Foundation for Innovative New Diagnostics (Switzerland)

Collaboration

Letter of intent to fast-track development of an antigen- based diagnostic for detecting active tuberculosis

Proteome Systems' test would detect TB antigens and monitor disease progression and treatment response; details were not disclosed (6/21)

pSivida Ltd.
(Australia; PSDV)

University of South Australia

Collaboration

Deal to evaluate pSivida's BioSilicon platform for drug delivery

The university's Ian Wark Research Institute will evaluate the controlled- release technology under a six-month deal (6/20)

RegeneRx Bio-
pharmaceuticals
Inc.
(AMEX:RGN)

Children's National Medical Center

Collaboration

To study the effects of thymosin beta 4 to treat degenerative muscle diseases

The center will test TB4 in non- human models that have a disease similar to human Duchenne's muscular dystrophy and go on to develop cardiomyopathy (8/4)

Rubicon
Genomics Inc.*

Genome Institute of Singapore

Agreement

Rubicon will isolate and amplify genomic DNA in archived serum samples

The samples are from 5,000 participants in a hepatitis B vaccine trial; GIS will use the DNA to discover genes relevant to HBV (7/21)

Sareum
Holdings plc
(UK; AIM:SAR)

The Institute of Cancer Research and Cancer Research Technology Ltd. (both in the UK)

Collaboration

To develop cancer drugs that target a biochemical pathway responsible for resistance to standard chemotherapeutics

Sareum will use its Template Screening technology to identify compounds; it would share in any payments, milestones and royalties arising from resulting license deals (7/25)

Serologicals
Corp.
(SERO)

Wisconsin Alumni Research Foundation

License agreement

Serologicals unit Chemicon International Inc. got nonexclusive rights to all WARF's stem cell technologies

Chemicon intends to commercialize research products derived from human embryonic stem cell technology; terms of the deal were not disclosed (7/25)

Sirna
Therapeutics
Inc.
(RNAI)

Massachusetts General Hospital

Sponsored research

For research into using siRNAs and related formulations as modulators of the retino-blastoma gene pathway

The goal is to promote regrowth and differentiation of hair cells that under natural conditions do not grow or divide in adult mammals (6/13)

Structural
GenomiX Inc.*

Cystic Fibrosis Foundation Therapeutics Inc.

Collaboration

Three-year deal to discovery therapies to treat the cause of cystic fibrosis

SGX will generate lead compounds that "correct" the delta F508 form of the CFTR protein; SGX gets $15M in technology access, research and milestone payments, and is eligible for clinical milestone payments and royalties on sales (7/6)

Targepeutics
Inc.*

National Institutes of Health

License agreement

Targepeutics licensed patents relevant to its genetically engineered interleukin-13 platform

The 10 patents give background rights for the platform; terms of the deal were not disclosed (8/17)

Tm Bioscience
Corp.
(Canada; TSE:TMC)

University of Miami

Supply agreement

Tm will provide reagents to the university

University researchers will use the technology in cystic fibrosis and Ashkenazi Jewish panel gene assays (7/27)

TriPath Imaging
Inc.
(TPTH)

Cancer Research Technology Ltd. (UK)

License agreement

TriPath got rights to a number of cancer diagnostic markers

The markers, from the Minichromosome Maintenance protein family, have applicability in various solid tumors (8/22)

U.S. BioDefense
Inc.
(OTC
BB:UBDE)

University of British Columbia (Canada)

License agreement

Option deal covering UBC's neural crest stem cell line and its use in human transplantation

U.S. BioDefense got a six-month option to license worldwide rights to the patent; terms were not disclosed (7/6)

Valentis
Inc.
(VLTS)

Vanderbilt University

License agreement

Valentis gained rights to the Del-1 antibody and associated intellectual property

Valentis had licensed rights to the Del-1 protein and gene in 1998; Del-1 is an angiogenic protein; terms were not disclosed (5/19)#

Xenomics Inc.
(OTC BB:XNOM)

Lazzaro Spallanzani Institute(Italy)

Agreement

They created a joint venture, SpaXen, to research Xenomics' diagnostic technology for detecting infectious disease

Licensing terms and royalties were covered in the deal, terms of which were not disclosed; the deal centers on Xenomics' Transrenal-DNA diagnostic technology (7/12)

YM BioSciences
Inc.
(Canada;
TSE:YM)

University of Saskatchewan (Canada)

License agreement

YM got exclusive rights to a portfolio of small-molecule oncology compounds

The compounds are believed to be highly potent chemopotentiators; terms were not disclosed (8/10)

York Pharma
plc
(UK;AIM:YRK)

Freie Universitat Berlin (Germany)

Acquisition

York acquired patents relating to sphingosine-1-phosphate

The preclinical technology may have applications in hyperproliferative skin disorders such as acne; the university gets an up-front payment and potential royalties (7/19)


Notes:

This chart does not include grants or contract awards, or agreements between biotech companies and clinical trial centers.

* Denotes privately held company.

@ Some institutions listed have for-profit components. They are located in the U.S. unless otherwise noted.

# Item occurred before the time frame of this chart but was not included in the previous chart.

Unless otherwise noted, shares are traded on the Nasdaq exchange.

AIM = Alternative Investment Market; AMEX = American Stock Exchange; ASX = Australian Stock Exchange; NYSE = New York Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; PK = Pink Sheets; TSE = Toronto Stock Exchange; VSE = Vienna Stock Exchange.