Company* |
Company* (Country; Symbol) | Type/Product Area | Terms/Details (Date) |
|
Advanced Biotherapy Inc. (OTC BB:ADVB) |
Innogenetics NV (Belgium; Euronext:INNX) |
Agreement combining Innogenetics' humanized antibody to interferon-gamma (INNO 202) and ABI's interferon-gamma intellectual property |
Proceeds from the cross-licensing deal will be shared; rheumatoid arthritis is their first target; both companies may continue to license their intellectual property rights to third parties (5/5) |
|
Affymetrix Inc. (AFFX) |
Immusol Inc.* |
Immusol will use GeneChip technology to identify pathways from its engineered tumor cells in biological assays |
Immusol seeks to discover and characterize new and existing targets for cancer therapies using the Affymetrix technology; terms were not disclosed (6/22) |
|
Amphora Discovery Corp. |
Caliper Life Sciences Inc. (CALP) |
Caliper acquired cell culture techniques, as well as upgrades Amphora implemented on Caliper's microfluidic screening system |
Amphora will get a combination of cash, Caliper products and royalties based on sales of cell-based assays (5/6) |
|
Aptanomics SA* (France) |
Nanosyn Inc.* |
Aptanomics will use its peptide aptamer technology to screen Nanosyn's small-molecule libraries for cancer applications |
Once hits are identified, Nanosyn will use its chemistry technologies to provide Aptanomics arrays of small molecules and other chemistry services; terms were not disclosed (5/4) |
|
Avidex Ltd.* (UK) |
Active Biotech AB (Sweden; SSE:ACTI) |
Collaboration to create targeted immunotherapeutics for cancer using their protein molecule platforms |
Active is contributing its superantigen protein and Avidex its platform of tumor antigen-specific human monoclonal T-cell receptors; terms were not disclosed (5/13) |
|
Biomax Solutions Inc.* |
Geospiza Inc.* |
They will integrate and jointly sell their bioinformatics systems |
Resulting products will be designed to turn DNA sequencing data into discovery information (6/9) |
|
BioSpecifics Technologies Corp. (OTC BB: BSTC) |
Auxilium Pharmaceuticals Inc.* |
Auxilium licensed certain therapeutic applications for a BioSpecifics' enzyme |
Auxilium will pay license fees and potential milestones and royalties, as well as a fee for manufacturing, in exchange for exclusive worldwide rights (6/7) |
|
Cellectis SA* (France) |
Murinus GmbH* (Germany) |
Murinus got nonexclusive rights to use homologous recombination to replace or in- ert genes in the mouse genome |
Murinus can develop and sell genetically modified mice in Europe and the Middle East under undisclosed terms (5/13) |
|
Chiron Corp. (CHIR) |
Prosetta Corp.* |
Prosetta got nonexclusive rights for research and development related to certain hepatitis C virus drug targets |
The deal is the first under which Chiron offers licenses that have no up-front or annual fees but could result in milestone and royalty payments (6/22) |
|
Chiron Corp. (CHIR) |
Oxford Biomedica plc (UK; LSE:OXB) |
Oxford acquired certain rights to Chiron technology in the area of gene therapy |
The technology complements Oxford programs in gene therapy; terms were not disclosed; separately, Chiron purchased 316,026 Oxford shares at 17.23 pence per share (6/7) |
|
CombinatoRx Inc.* |
Immtech International Inc. (AMEX:IMM) |
CombinatoRx will screen Immtech aromatic cationic compounds DB289 and DB75 against various cancers |
Terms of the deal were not disclosed (5/5) |
|
Cytomyx Holdings plc (UK; LSE:CYX) |
Paradigm Therapeutics Ltd.* (UK) |
Deal to produce and sell mammalian cell lines containing the ion channel subunit SCN3B |
Terms of the deal were not disclosed (5/5) |
|
Cytomyx Holdings plc (UK; LSE:CYX) |
CellFactors plc* (UK) |
Deal to develop and sell human brain-derived cell lines that were created at CellFactors |
Cytomyx will further validate 11 NeuCell lines and commercialize them worldwide; they would share revenues (4/20)# |
|
Dyax Corp. (DYAX) |
Genzyme Corp. (GENZ) |
Genzyme got nonexclusive rights to antibody phage- display libraries for the discovery of human antibodies |
Dyax gets an up-front license fee and potential milestones and royalties; Genzyme has an option to convert the license from research use to antibody development, and to fund research work by Dyax (6/2) |
|
EiRx Therapeutics plc (Ireland; LSE:ERX) |
OSI Pharmaceuticals Inc. (OSIP) |
OSI exercised an option to license four apoptosis gene targets and move them into drug discovery in oncology |
OSI for a year had been evaluating about 12 targets, and licensed four of them; EiRx gets up-front and consultancy fees, and potential success fees and milestones for each target (5/5) |
|
Evotec OIA AG (Germany; FSE:EVT) |
NeuroNova AG* (Germany) |
Deal to identify small-molecule compounds that interact with a Neuronova target for depression and anxiety |
Evotec will provide technologies and services to the collaboration, terms of which were not disclosed (6/14) |
|
Evotec OIA AG (Germany; FSE:EVT) |
Nuvios Inc.* |
Evotec will screen small- molecule compounds for osteoporosis applications |
The goal is to discover novel activators of bone anabolic activity; terms were not disclosed (5/19) |
|
Evotec OIA AG (Germany; FSE:EVT) |
Guilford Pharmaceuticals Inc. (GLFD) |
Deal under which Evotec will identify small-molecule compounds that interact with certain Guilford targets |
Evotec will get research fees and milestones based on successful preclinical development (5/13) |
|
Formatech Inc.* |
Mirus Therapeutics Corp.* |
Mirus acquired formulation/ drug delivery technologies from Formatech |
Mirus plans to develop improved formulations of existing drugs, and to partner the technology; terms of the deal were not disclosed (6/17) |
|
4SC AG* (Germany) |
Serono SA (Switzerland; NYSE:SRA) |
Serono got exclusive worldwide rights to 4SC's program of small-molecule dihydroorotate dehydrogenase inhibitors for autoimmune diseases |
4SC gets an up-front payment, research funding and potential milestones that together could total $67M; it also would get royalties on sales; the deal includes the lead Phase I compound, SC12267 (5/4) |
|
Genedata AG* (Switzerland) |
MWG Biotech AG* (Germany) |
Co-marketing agreement to offer functional genomics services for partners |
The Genedata Phylosopher platform will be used with MWG products; terms of the deal were not disclosed (6/11) |
|
Genentech Inc. (NYSE:DNA) |
Tercica Inc. (TRCA) |
Tercica gained rights to insulin- like growth factor-1 combined with insulin-like growth factor binding protein-3 |
Tercica paid $1.3M in exercising its option; the exclusive license covers all indications outside of CNS disorders and is worldwide except for diabetes outside the U.S. (6/15) |
|
Genzyme Corp. (GENZ) |
Peptimmune Inc.* |
Peptimmune licensed worldwide rights to GT389-255, a candidate for obesity and other metabolic disorders |
Peptimmune plans to file an IND on the product later this year; it will pay Genzyme royalties on any sales and share payments from any partners for the drug (5/10) |
|
Geron Corp. (GERN) |
CXR Biosciences Ltd.* (UK) |
Collaboration, along with the Roslin Institute, to develop human embryonic stem cell- derived hepatocytes |
They will be used in in vitro assays of drug metabolism and toxicity; Geron and CXR would commercialize resulting products; terms were not disclosed (5/20) |
|
GTx Inc. (GTXI) |
DiaDexus Inc.* |
GTx will provide clinical data from a trial of Acapodebe in men with high-grade prostatic intraepithelial neoplasia |
DiaDexus will use the data to develop an assay or test to detect high-grade PIN and/or prostate cancer; terms were not disclosed (6/15) |
|
Guilford Pharmaceuticals Inc. (GLFD) |
Symphony Neuro Development Co.* |
Symphony licensed U.S. rights to the neuroimmunophilin ligand GPI 1485 in Parkinson's disease and uses related to HIV and erectile dysfunction |
SNDC investors got five-year warrants to purchase 1.5M Guilford shares at $7.48 per share; Guilford has an option to reacquire the product for $75.1M to $119.8M; SNDC was formed specifically for this deal (6/18) |
|
Incyte Corp. (INCY) |
Ingenium Pharmaceuticals AG* (Germany) |
Ingenium acquired two patents related to genetic rat and mouse models |
Ingenium previously had a license to the patents, Nos. 5,994,075 and 6,015,670; terms were not disclosed (5/12) |
|
Intercell AG* (Germany) |
Solvo Biotechnology Inc.* (Hungary) |
Solvo got an exclusive license to develop a diagnostic product for detecting PIBF in human patient samples |
The deal covers Intercell's progesterone-induced blocking factor technology; terms were not disclosed (6/23) |
|
Juvaris BioTherapeutics Inc.* |
SomaGenics Inc.* |
Deal to combine RNA-based gene-inhibition technology of SomaGenics with Juvaris' immunomodulatory and vaccine technology |
The initial focus is on developing a product that could be used to elicit both non-specific and specific protection against anthrax and anthrax toxin; terms were not disclosed (5/12) |
|
Labopharm Inc. (Canada; TSE:DDS) |
Debiopharm SA* (Switzerland) |
Labopharm will research the potential oral delivery of a Debiopharm cancer drug |
Labopharm will apply its nanodelivery systems technology (asmicelles technology) in the deal, terms of which were not disclosed (6/16) |
|
Lantibio Inc.* |
AOP Orphan Pharmaceuticals AG* (Austria) |
AOP will assume control of developing Moli1901 in Europe for treating cystic fibrosis |
Lantibio gets undisclosed up-front payments as well as potential milestones and royalties; AOP is planning a Phase II trial in Germany (5/26) |
|
LGC Ltd.* (UK) |
ChemOvation* (UK) |
Collaboration to combine technologies in order to improve offerings to drug discovery companies |
They will bring together ChemOvation's medicinal and organic chemistry and LGC's biomeasurement cell-based testing capabilities; terms were not disclosed (5/6) |
|
Mimetix Inc.* |
Symbollon Pharmaceuticals Inc. (OTC BB:SYMBA) |
Symbollon acquired assets on iodine drug development, which it will use in its IoGen program |
Symbollon issued 550,000 shares for the assets, which include trial data from women with fibrocystic breast condition treated with molecular iodine (6/14) |
|
Mologen AG* (Germany) |
MEBO International Group (China) |
Agreement to develop comb- ination treatments against cancer |
They will combine Mologen's fourfold immunomodulated tumor cells and MEBO's herbal extracts; they would file for joint patents on resulting products (4/27)# |
|
Nautilus Biotech* (France) |
Serono SA (Switzerland; NYSE:SRA) |
Collaboration to develop therapeutic proteins with improved characteristics |
Nautilus will design and validate protein variants; Serono would develop and market resulting products; terms of the deal were not disclosed (6/21) |
|
Nektar Therapeutics (NKTR) |
SciClone Pharmaceuticals Inc. (SCLN) |
Deal to use Nektar technology to develop a pegylated form of Zadaxin |
The SciClone product is being developed for treating hepatitis C; terms of the deal were not disclosed (5/26) |
|
Orphan Therapeutics LLC* |
ESP Pharma Inc.* |
ESP acquired rights to intra- venous terlipressin, a drug in Phase III trials for Type I hepato-renal syndrome |
ESP will make up-front and potential milestone and royalty payments in exchange for exclusive rights in the U.S. and Canada (6/8) |
|
PamGene International BV* (the Netherlands) |
Jerini Peptide Technologies (unit of Jerini AG*; Germany) |
Collaboration to combine technologies to provide a new offering for kinase studies |
The resulting product offering would have applications in signal transduction-focused research; terms of the deal were not disclosed (6/22) |
|
PamGene International BV* (the Netherlands) |
Innogenetics NV* (Belgium; Euronext:INNX) |
Innogenetics gets access to PamGene's microarray tech- nology platform for the development of assays |
PamGene gets an up-front payment, milestones as tests reach the market, and royalties on sales in exchange for the exclusive license to its PamStation 12 instrumentation in certain indications (5/27) |
|
ProMetic Life Sciences Inc. (Canada; TSE:PLI) |
Hemosol Inc. (Canada; TSE:HML) |
Hemosol licensed plasma- separation technology developed by ProMetic and the American Red Cross |
Hemosol issued 2M shares to ProMetic and will pay license fees of C$15.5M (US$11.3M) over four years, as well as issue another 1M shares; the cascade-purification technology is used to recover proteins from human plasma (6/2) |
|
Prosidion Ltd. (UK unit of OSI Pharmaceuticals Inc.; OSIP) |
Probiodrug AG* (Germany) |
Prosidion purchased dipeptidyl peptidase IV technology, which is in Phase II trials for treating Type II diabetes |
Probiodrug gets $35M in cash and potential development milestones; OSI is investing another $50M in Prosidion and will own 96% of the subsidiary (6/18) |
|
ProteomTech Inc.* |
Pivotal BioSciences Inc.* |
ProteomTech will help Pivotal with protein expression and development processes for PB1 |
The product is an analogue of interleukin-2; terms were not disclosed (5/5) |
|
Raven Biotechnologies Inc.* |
ICOS Corp. (ICOS) |
ICOS got an exclusive option to license five Raven monoclonal antibody candidates with applications in cancer |
Raven will receive an up-front payment as well as potential milestones and royalties on sales; further terms were not disclosed (6/9) |
|
Seattle Genetics Inc. (SGEN) |
CuraGen Corp. (CRGN) |
CuraGen licensed antibody- drug conjugate technology for use with its antibodies in treating cancer |
Seattle Genetics gets $2M up front and up to $28M in milestones if two products are developed; CuraGen also will pay other fees and would pay royalties on sales (6/22) |
|
Senetek plc (SNTK) |
Ardana Bioscience Ltd.* (UK) |
Ardana will manufacture and market Senetek's Invicorp erectile dysfunction treatment in Europe |
Ardana assumes all reponsibility in Europe for the injectable product; Senetek can earn regulatory and sales milestones, as well as royalties on sales (6/21) |
|
SkyePharma plc (UK; SKYE) |
Trigenesis Therapeutics Inc.* |
SkyePharma licensed to Trigenesis dermatology assets that include residual rights to three marketed products, six pipeline products and various delivery technologies |
SkyePharma gets up-front payments for each of the six development products, as well as potential milestones, which together could exceed $20M; it also would get 10% royalties and 35% of any sublicense fees (4/29) |
|
Syntonix Pharmaceuticals Inc.* |
Dyax Corp. (DYAX) |
Collaboration to discover and develop antibodies for auto- immune and inflammatory disorders |
Syntonix will provide assays, reagents and certain preclinical development work, and Dyax will screen for candidates using its antibody libraries; development and financial terms were not disclosed (5/13) |
|
TopoTarget A/S* (Denmark) |
CuraGen Corp. (CRGN) |
Deal to develop TotoTarget's PXD101, a histone deacetylase inhibitor that is in Phase I trials for cancer indications |
In exchange for worldwide rights excluding Europe, CuraGen is making a $5M equity investment and paying $5M in license fees, up to $14M over 36 months in milestones and research support, and up to $27M more in milestones; they would pay reciprocal sales royalties; CuraGen also got an option to additional HDAC compounds for which it would pay up to $1M in license fees and $30M in milestones per product (6/3) |
|
Valentis Inc. (VLTS) |
Juvaris BioTherapeutics Inc.* |
Juvaris got exclusive rights to Valentis' plasmid backbone in conjunction with its DOTIM cationic lipid for use in therapeutic vaccines |
Valentis will receive cash payments and be eligible for development milestones and royalties on sales (6/4) |
|
Vectura Ltd.* (UK) |
SkyePharma plc (UK; SKYE) |
SkyePharma will use Vectura's Aspirair dry-powder inhaler for delivering certain macro- molecules |
SkyePharma invested £2M (US$3.7M) in Vectura, or 4% of the company, for the non-exclusive rights; further terms were not disclosed (6/2) |
|
ViroPharma Inc. (VPHM) |
SIGA Technologies Inc. (SIGA) |
SIGA is acquiring certain viral research programs targeting agents that could be used in biological warfare |
ViroPharma gets $1M in cash and 1M SIGA shares; the targets include smallpox and hemorrhagic fever viruses (6/9) |
|
Xerion Pharmaceuticals AG* (Germany) |
Stemline Therapeutics Inc.* |
Collaboration to identify novel protein targets expressed on cancer stem cells |
They will share costs and revenues from the deal, under which they will apply Xerion's Xstream technology to Stemline's cancer stem cell platform (6/9) |
|
XTL Biopharmaceuticals Ltd. (Israel; LSE:XTL) |
Cubist Pharmaceuticals Inc. (CBST) |
Worldwide license deal for XTL's Phase II product HepeX-B for preventing hepatitis B re-infection in liver transplant patients |
Cubist will fund development and be responsible for sales; XTL will get collaboration support and $3M over two years, as well a potential $3M regulatory milestone payment and 10% to 17% on net sales (6/3) |
|
ZymoGenetics Inc. (ZGEN) |
Amgen Inc. (AMGN) |
Amgen got exclusive world- wide rights to ZymoGenetics' patents covering a metabolic disease target |
Amgen is purchasing $10M of ZymoGenetics stock, as well as paying an up- front license fee and potential downstream consideration (5/20) |
|
Notes: | ||||
* Private companies are indicated with an asterisk. | ||||
# Item occurred before April 20 but was not included in the previous chart. | ||||
Unless otherwise noted, the trading symbols listed for public biotechnology companies are on the Nasdaq market. | ||||
FSE = Frankfurt Stock Exchange; LSE = London Stock Exchange; NYSE = New York Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; TSE = Toronto Stock Exchange. |