I. MODIFIED AGREEMENTS

Company* (Country; Symbol)

Company* (Country; Symbol)

Change from original agreement

Terms/Details (Date)

Genencor International Inc. (GCOR)

Ciphergen Biosystem Inc. (CIPH)

Expansion of license agreement covering production and marketing of products based on Genencor's Hydrophobic Charge Induction chromatography technology

Ciphergen uses the technology in the production of MEP HyperCel sorbent; Ciphergen gets the right to use and distribute products based on the technology (1/21)

Genentech Inc. (NYSE:DNA) and Novartis Pharma AG (Switzerland)

Tanox Inc. (TNOX)

Companies finalized terms settling all litigation related to three-way deal on developing anti-IgE antibodies, including Xolair and TNX-901

Genentech and Novartis each will reimburse Tanox $3.3 million for TNX-901 development costs; Tanox will relinquish any rights to manufacture Xolair, and will receive payments tied to the quantity of Xolair produced; and Tanox will get accelerated forgiveness of a manufacturing loan; royalty and profit-sharing arrangements remain the same (2/26)

MorphoSys AG (Germany; FSE:MOR)

GPC Biotech AG* (Germany)

GPC extended its exclusive license for HuCAL antibodies directed against an MHC Class II target molecule

MorphoSys received an undisclosed payment (1/28)

Seattle Genetics Inc. (SGEN)

Protein Design Labs Inc. (PDLI)

Expanded antibody-drug conjugate deal under which SGI will provide additional R&D support for product development

SGI will get increased fees, milestones and royalties under the modified deal; PDL has rights to exclusive licenses to the technology for use with antibodies against targets it selects (1/12)

II. TERMINATED AGREEMENTS

Genome Therapeutics Corp. (GENE)

Amgen Inc. (AMGN)

Companies ended January 2003 collaboration focused on discovering and developing therapeutics for bone diseases

Genome Therapeutics retains certain intel- lectual property and licensing rights related to a gene discovered during the collaboration (1/9)

Notes:

* Private companies are indicated with an asterisk.

Unless otherwise noted, stock symbols listed are on the Nasdaq market.

FSE = Frankfurt Stock Exchange; NYSE = New York Stock Exchange.