Biotech Co.*
(Country; Symbol)

Agbiotech Partner (Country; Symbol)

Type/Product Area

Terms/Details (Date)

Amarillo Biosciences Inc. (OTC BB:AMAR)

Chihiro Sugimoto and Takeshi Matsumura, and Hayashibara Biochemical Laboratories Inc.* (Japan), Hokkaido Green-Bio Institute (Japan), and Hokuren Federation of Agricultural Cooperatives (Japan)

Option agreement to examine the transgenic delivery of human interferon alpha through potato plants

Amarillo will evaluate the commercial possibilities of growing human interferon alpha (9/3)

Avant Immunotherapeutics Inc. (AVAN)

Lohmann Animal Health International*

Agreement in which Lohmann becomes the exclusive distributor of Avant's Megan Health poultry vaccines in North America

Financial terms were not disclosed (9/3)

Biodelivery Sciences International Inc. (BDSI)

Undisclosed manufacturing company

Exclusive licensing agreement in the veterinary field to evaluate BDSI's nanocochleate delivery technology for applications in pet food

The manufacturer will conduct a trial using BDSI's delivery technology to supplement pet food with an antioxidant (9/19)

Bioject Medical Technologies Inc. (BJCT)

Merial (joint venture between Merck and Co. Inc., NYSE:MRK; and Aventis SA, France, NYSE:AVE)

Exclusive license and supply agreement to deliver via a needle-free injector system veterinary pharmaceuticals and vaccines for Merial

Merial will initially develop the system to deliver vaccines to food-producing animals; Bioject will receive monthly payments, as well as potential milestone and royalty payments (8/15)

Bureau Veritas Quality International GmbH* (UK)

GeneScan Analytics GmbH (Germany; Neuer Markt:GEPG)

Global cooperation agreement to support agricultural and food companies in setting up and certifying control systems to keep products from genetically modified organisms separate from conventionally produced products

The deal anticipates the introduction of labeling requirements in the European Union as early as 2003 for products made from genetically modified organisms (6/26**)

BioSciences LLC*

Dow AgroSciences LLC (subsidiary of
The Dow Chemical

Three-year collaboration to develop insecticides for crop protection and urban pests

Cambria will apply its technology to identify the mechanism of action of certain compounds and design assays that will be used by Dow to develop classes of insecticides (10/28)

F2G Ltd.* (UK)

Dow AgroSciences LLC (subsidiary of
The Dow Chemical

Research collaboration in the discovery of antifungals for use as agrochemicals and drugs

Both companies will synthesize new compounds, which F2G will screen for pharmaceutical potential for use in agrochemicals, pest control and animal health (10/23**)

GeneSeek Inc.*

Sequenom Inc. (SQNM)

Agreement to enable high-throughput genetic analysis and identify testing for the livestock industries

Sequenom placed a MassArray system in GeneSeek's new genetic analysis facility, which will be used to scan livestock for genetic variations for applications such as gene discovery, trait testing, viral and bacterial identification, parentage analysis and identity matching for accurate tracing of meat products through the full chain of production (8/26)

Large Scale Biology Corp. (LSBC)

Growers Research Group LLC*

A long-term biological materials manufacturing and supply agreement

The contract includes both a supply agreement and upside profit sharing based on anticipated Growers Research sales of one or more materials; Large Scale will produce and supply to Growers Research its requirements for one or more grades of an antimicrobial enzyme that Growers Research will market for agricultural and other commercial applications (6/28)

LION bioscience AG (Germany; LEON)

Biogemma* (France) and RhoBio* (joint venture between Bayer Crop Science and Biogemma)

Licensing agreement for LION's SRS and bioScout technology, aimed at improving plant disease research

RhoBio will deploy LION's SRS technology for better integration of genetic data related to plant disease research; Biogemma will be using LION's bioScout application to analyze gene sequences to develop better crop protection strategies (9/19)

Neose Technologies Inc. (NTEC)

Monsanto Protein Technologies (unit
of Monsanto Co.; NYSE:MON)

Research agreement to investigate the use of Neose's GlycoAdvance technology to enhance the glycosylation of therapeutic monoclonal antibodies produced in plants

The research will combine Monsanto's knowledge of transgenic plant production of monoclonal antibodies with Neose's knowledge of glycosylation (11/25)

Plant Research International BV*
(the Netherlands)

The Dow Chemical Co. (NYSE:DOW)

Agreement to work to expand the use of plant-based production for pharmaceutical proteins

Financial terms were not disclosed (11/5)

Prodigene Inc.*

FibroGen Inc.*

Research agreement for the production of recombinant gelatin in maize

The collaboration will focus on the use of ProdiGene's transgenic plant system and FibroGen's methods for the production of a source of FibroGen's recombinant gelatin; financial terms were not disclosed (6/5)

International Inc.*

AgriGenomics Inc.* (Canada)

Agreement to acquire exclusive worldwide licenses to technologies that have resulted in the development of plants that grow and thrive when fertilized with lower levels of nitrogen than required

Financial terms were not disclosed (8/13)

Senesco Technologies Inc. (AMEX:SNT)

ArborGen LLC*

Development and option collaboration to enable the companies to incorporate Senesco's technology into forestry products being developed by ArborGen

Financial terms were not disclosed (7/2)

Senesco Technologies Inc. (AMEX:SNT)

Cal/West Seeds*

Development and license agreement to incorporate Senesco's technology into the enhanced alfalfa varieties being developed by Cal/West

The agreement includes options for the development of various other forage crops; financial terms were not disclosed (9/18)

Senesco Technologies Inc. (AMEX:SNT)

Tianjin Academy
of Agricultural Sciences*

Agreement requiring Senesco to transfer its technology that regulates the onset of cell death to the academy for use in fruit and vegetable crops

Senesco stands to gain about $35M in up-front fees upon the transfer of the technology, and potential royalties on future sales; other payments would be made to Senesco over a multiyear period in conjunction with training and support (11/5)


This chart contains information on new and revised corporate agreements in agricultural biotechnology, covering the time between 5/31/02 and 11/26/02.

* Private companies are indicated with an asterisk.

** Denotes the date the item ran in BioWorld International.

Unless otherwise indicated, shares are traded on the Nasdaq exchange.

AMEX = American Stock Exchange; NYSE = New York Stock Exchange; OTC BB = Over-the-Counter Bulletin Board