November 22 (EP), November 16 (WO)

Alabama, Univ. of WO 00/67576

Cancer gene therapy

Birmingham, Ala.

Conditionally replicative adenovirus vectors with enhanced tumor infectivity and tumor selective replication.

AstraZeneca WO 00/68268

Human GABAB receptor 1 promoters

Sodertalje, Sweden

Human GABAB receptor 1 promoters; for use in developing modulator screens.

BASF WO 00/67790

TNF receptor modulation

Ludwigshafen, Germany

Modulators of cellular TNF receptor content; for treating TNF-induced diseases.

Becton Dickinson WO 00/68270

Plasmodium detection

Franklin Lakes, N.J.

Repeated peptides from Plasmodium vivax ESP-1 protein, antibodies; for diagnostics and therapeutics.

Bristol-Myers Squibb WO 00/68413

Nocathiacin antibiotics

Princeton, N.J.

Halo- or hydroxy-substituted nocathiacin antibiotics produced by fermentation in Nocardia strains.

Burnham Inst. WO 00/67771

Antiangiogenesis therapeutics

La Jolla, Calif.

Antiangiogenic endostatin peptides, endostatin variants, functional equivalents; for therapeutics.

California, Univ. of WO 00/68248

Self-assembling proteins

Oakland, Calif.

Fusion proteins that assemble into regular structures, encoding genes; for preparing nanostructures.

California, Univ. of WO 00/68265

Antimicrobial defensins

Oakland, Calif.

Antimicrobial cyclic peptide theta defensins, encoding gene sequences; for infection therapeutics.

California, Univ. of WO 00/68382

Prion disorder gene

Oakland, Calif.

Gene encoding Doppel protein, encoded protein, antibodies; for identifying individuals at risk for prion disorders.

CNRS (Natl. Ctr. Sci. Res.) WO 00/67697

Gene delivery vehicle


Nucleic acid-antibody conjugates; for gene delivery into target cells.

CNRS (Natl. Ctr. Sci. Res.) WO 00/67792

Renal cell carcinoma antibodies


Monoclonal antibodies directed against human renal cell carcinoma.

Children's Hosp. WO 00/68433

Autism diagnosis

Los Angeles

Detection of human aromatic L-amino acid decarboxylase gene mutations; for autism diagnosis.

Chugai WO 00/68371

Cell culture methods


Culture of parent cells with a transformed strain that constitutively produces a specific protein.

Connecticut, Univ. of WO 00/68432

Diagnosing congenital glaucoma

Farmington, Conn.

Measurement of human cytochrome P4501B1 gene mutations; for diagnosing primary congenital glaucoma.

Curie Inst. WO 00/68424

FGF receptor 3 mutations


Detection of mutations in the fibroblast growth factor receptor 3 gene; for detecting carcinomas.

Du Pont WO 00/68366

Processing protease ligand assays

Wilmington, Del.

D1 C-terminal processing protease crystals; for structural determination and ligand identification.

Eli Lilly WO 00/68266

Amyloid precursor protein protease


Amyloid precursor protein protease, encoding gene sequences; for developing Alzheimer's therapeutics.

European Molec. Biol. Lab WO 00/68423

Gene expression assays

Heidelberg, Germany

Isolation of polysomal mRNA for subsequent expression analyses; for enhanced gene expression assays.

European Molec. Biol. Lab WO 00/68693

Hsp90 fragments

Heidelberg, Germany

Methods for finding fragments, derivatives, and analogs of Hsp90 that are altered in their subcellular localization.

Genentech WO 00/67796

Autoimmune disease therapy

S. San Francisco

Treatment of autoimmune diseases with antagonists that bind to B cell surface markers.

Genentech WO 00/68363

Elastase variants

S. San Francisco

Elastase variants, substrates; for developing diagnostics and therapeutics.

Genentech WO 00/68376

Chimpanzee EPO

S. San Francisco

Chimpanzee erythropoietin, encoding gene sequences, chimeras, antibodies, recombinant production methods.

Harvard Univ. WO 00/68185

Protein processivity factor modulators

Cambridge, Mass.

Structure-based methods to design peptidomimetics that inhibit the protein processivity factor.

Human Genome Sciences WO 00/67775


Rockville, Md.

Fibroblast growth factor 15, encoding genes, antibodies, production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 00/67793

Death domain containing receptor 4

Rockville, Md.

Death domain containing receptor 4, encoding gene, recombinant production methods; for modulator screens.

Human Genome Sciences WO 00/68247

Serine proteases

Rockville, Md.

Serine proteases, encoding genes, recombinant production methods; for diagnostics and therapeutics.

Illinois, Univ. of WO 00/68392

RSV vaccines from plants

Urbana, Ill.

Insertion of respiratory syncytial virus-based vectors that express viral antigens into plants; for making vaccines.

Immune Response WO 00/67787

HIV immunoresponse

Carlsbad, Calif.

HIV-derived antigens; for enhancing _-chemokine levels and inducing immunoresponses.

Immunex WO 00/68383



Leukocyte immunoglobulin-like receptors, encoding gene sequences, antibodies; for use as immunoregulators.

Immunomedics WO 00/67795

B-cell cancer antibodies

Morris Plains, N.J.

Methods for using antibodies that bind to CD22 or CD19 antigen to treat B-cell malignancies.

Incyte Genomics WO 00/68380

Extracellular matrix proteins

Palo Alto, Calif.

Extracellular matrix and adhesion-associated proteins, encoding genes, antibodies, modulators; for therapeutics.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/68429

Glaucoma diagnosis


Measurement of ApoE or ApoE promoter alleles; for diagnosing glaucoma.

Japan Sci. & Technol. EP 1 054 057

Point mutation generation

Kawaguchi, Japan

Introduction of point mutations into genomic DNA such that one strand has more such mutations.

JCR Pharma EP 1 054 058

Muscular dystrophy antisense

Hyogo, Japan

Antisense oligonucleotide against exon 19 of dystrophin pre-mRNA; for treating muscular dystrophy.

Leiv Eiriksson Nyfotek WO 00/68375

Antibiotic resistance assay

Trondheim, Norway

Modified TOL plasmid promoter; for cell insertion to study antibiotic resistance.

Life Technologies WO 00/68411

Enhanced DNA synthesis

Rockville, Md.

Polypeptides having specific affinity for double- and single-stranded nucleic acid molecules; for synthesis.

Lindahl, G. WO 00/68259

Staphylococcus vaccines

Lund, Sweden

Antigenic proteins from Staphylococcus pyogenes; for making group B Staphylococcus vaccines.

Ludwig Inst. Cancer Res.

Ocular disorder mutations

New York

Mutations in the gene encoding 11-cis retinal dehydrogenase, encoded protein; for ocular disorder diagnostics.

Maryland, Univ. of WO 00/67784

Bacterial infection vaccines

Baltimore, Md.

Bacteriophage from bacterial genomes, extrachromosomal elements; for producing antibodies and vaccines.

Mass. Gen. Hosp. WO 00/68361

Hair growth induction


Expression of versican in dermal papilla cells; for inducing and modulating hair growth.

Merck WO 00/68377

Platelet collagen receptor

Darmstadt, Germany

Recombinant platelet collagen receptor glycoprotein VI, encoding gene; for modulator assays.

Merck Frosst Canada WO 00/68414

Cathepsin K modulator assay

Kirkland, Que.

Whole cell assay system for measuring cathepsin K; for identifying modulators.

Microscience WO 00/68261

Attenuated Salmonella strains

Wokingham, U.K.

Salmonella strains with attenuating mutations disrupting gene expression from the Spl2 pathogenicity island.

Minnesota, Univ. of WO 00/68399

Transposon-mediated gene insertion

Minneapolis, Minn.

Non-integrating vectors containing a transposon and gene sequences encoding a transposase; for gene integration.

Mycota Biosciences WO 00/68420

Antifungal drug assays


Identification of essential genes in Candida albicans; for antifungal drug development.

NABI WO 00/67785

Staphylococcus vaccines

Rockville, Md.

Staphylococcus hexosamine-containing antigen; for making strains having this antigen to use as whole cell vaccines.

Natl. Ctr. Retroviuses WO 00/68436

HIV-1 subtype detection

Zurich, Switzerland

Detection of various subtypes of HIV-1 using nucleic acid amplification methods.

NIH (Natl. Inst. Hlth.) WO 00/68379

Antiangiogenesis therapy

Bethesda, Md.

Antiangiogenic gene inserted into a viral vector; for treating various cancers.

Natl. Jewish Med. & Res. Ctr. WO 00/68378

B cell growth regulation


Monocyte- and macrophage-expressed TALL-1 gene, encoded protein; for regulating B cell proliferation.

Neugenesis WO 00/68372

Metabolic pathway assays

San Carlos, Calif.

Methods for screening combinatorial libraries of multimeric proteins; for studying metabolic pathways.

Neurochem WO 00/68263

Amyloid disorder therapy


Steroselective anti-fibrillogenic peptides, peptidomimetics; for treating amyloidosis disorders.

Niseho EP 1 054 066

Osteoporosis-related polymorphisms

Osaka, Japan

Methods for analyzing genetic polymorphisms of the vitamin D receptor gene; for osteoporosis diagnosis.

Palsson, B.O. WO 00/68687

Drug candidate screens

La Jolla, Calif.

Using cells from normal and diseased tissues to measure differential effects of putative therapeutic agents.

Relag WO 00/67569

Cell reprogramming

Melbourne, Australia

Production of heterokaryons containing embryo nuclei; for cell reprogramming to form embryos.

Rhein Biotech WO 00/68400

Protein production methods

Dusseldorf, Germany

Identification of nucleic acid sequences that enhance protein secretion; for recombinant protein production.

Rhone-Poulenc WO 00/68401

Protein production methods

Antony, France

Recombinant strains of Penicillium funculosum; for production of heterologous proteins.

Ruprecht Karls Univ. WO 00/68435

Retrovirus detection

Heidelberg, Germany

Using reverse transcriptase PCR and reverse dot blot hybridization to detect retroviruses in samples.

Salk Inst. Biol. Studies WO 00/68269

Chimeric receptor proteins

La Jolla, Calif.

Chimeric proteins having receptor fragment and ligand domains; for identifying additional ligands.

SmithKline Beecham WO 00/67575 & 67783

Antibacterial screens


Bacterial proteins, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/67580

Splicing modulators


Methods for using splicing reactions to identify modulators of eukaryotic splicing.

SmithKline Beecham WO 00/67780

Antibacterial screens


Bacterial FabH proteins, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/68140

Staphylococcus antibacterial screens


Staphylococcus signal transduction response regulators, encoding gene; for antibacterial screens.

SmithKline Beecham WO 00/68240 & 68243

Antibacterial screens


Bacterial aroA proteins, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/68244

7-transmembrane receptor modulation


Mouse 7-transmembrane receptor, encoding gene, recombinant production methods; for modulator screens.

SmithKline Beecham WO 00/68250

7-transmembrane receptor modulation


Rat 7-transmembrane receptor, encoding gene, recombinant production methods; for modulator screens.

SmithKline Beecham WO 00/68360

Staphylococcus antibacterial screens


Staphylococcus aureus histidine kinase, encoding gene, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/68365

Staphylococcus antibacterial screens


Staphylococcus pneumoniae tRNA methyltransferases, encoding gene, production methods; for antibacterial screens.

SmithKline Beecham WO 00/68425

Antibacterial screens


Bacterial ysxC proteins, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/68426

Antibacterial screens


Bacterial ups proteins, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/68427

Antibacterial screens


Bacterial yphC proteins, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/68430

Staphylococcus antibacterial assays


Staphylococcus aureus Rnase P, encoding gene, recombinant production methods; for antibacterial screens.

South Carolina, Med. Univ. of WO 00/68249

G-protein modulators

Charleston, S.C.

G-protein modulator proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Stem Cell WO 00/67568

Cell reprogramming

Elstemwick, Australia

Production of heterokaryons containing embryo nuclei; for cell reprogramming to form embryos.

Sterrenbeld Biotech WO 00/68253

Gene expression promoter

Wilmington, Del.

Promoter derived from Staphylococcus aureus phage that is active in Gram-positive and -negative bacteria.

Target Quest EP 1 054 018

Fab fragment libraries

Maastricht, Netherlands

Fab fragment libraries; for isolating polyclonal or monoclonal antibodies with high specificity.

Telethon Inst. Child Hlth. Res. WO 00/68373

Modulator assays

Subiaco, Australia

Identifying biological activity modulators using diverse gene fragment libraries.

Texas A&M Univ. WO 00/68242

Bacterial collagen-binding proteins

College Stn., Texas

Collagen-binding proteins from enterococcal bacteria; for treating and preventing infections.

Toyo Kohan EP 1 054 056

Genome comparison assay


Apparatus for immobilizing DNA libraries in isolated sections; for genome comparisons.

Tularik WO 00/68686

Mitochondrial membrane potential modulators

S. San Francisco

High-throughput screening assays for identifying modulators of mitochondrial membrane potential uncoupling proteins.

U.S. Army Med. Res. Command WO 00/67700

Botulism vaccine

Ft. Detrick, Md.

Synthetic genes encoding protective epitopes from botulinum neurotoxin, encoded proteins; for making a vaccine.

Utah, Univ. of WO 00/68359

Neuroepithelial stem cells

Salt Lake City

Lineage-restricted precursor cells isolated from mouse neural tube and embryonic stem cells, isolation methods.

Vermicon WO 00/68421

Microorganisms detection

Munich, Germany

Detection of microorgansims in samples using probes for hybridization assays.

Vessel Res. Lab EP 1 053 677

Myosin transgenics


Cells transfected with genes for expressing smooth muscle myosin heavy chain; for making transgenics.

Visible Genetics WO 00/68410

Nucleic acid sequencing


Nucleic acid sequencing with simultaneous quantitation using a single set of reagents.

Vlaams Inst. Biotech EP 1 054 059

Catenin-binding protein genes

Zwijnaarde, Belgium

Catenin-binding protein genes, encoded proteins; for modulating transcription and gene regulation.

Wake Forest Univ. WO 00/67761

Eliciting immunoresponses

Winston-Salem, N.C.

Transfection with gene constructs encoding antigens; for presentation to T cells to elicit an immune response.

Xencor WO 00/68384

Altered p53 proteins

Pasadena, Calif.

p53 proteins with altered tetramerization domains, encoding gene sequences; for cancer therapeutics.

Xencor WO 00/68385

Proteins with GH activity

Pasadena, Calif.

Proteins having growth hormone activity, encoding gene sequences; for treating growth hormone-related disease.

Xencor WO 00/68387

Proteins with IFN-_ activity

Pasadena, Calif.

Proteins having interferon-_, encoding gene sequences; for treating IFN-_ related disease.

Yale Univ. WO 00/68434

Multiple tag analysis

New Haven, Conn.

Detection of multiple analytes using decodable tags for marking the analytes; for diagnostics development.

Zeneca WO 00/68362

Erythroid stem cells


Undifferentiated erythroid cells transfected with heterologous genes controlled by globin promoters.

ZymoGenetics WO 00/68381

Cytokine receptor


Mouse cytokine receptor, encoding gene, antibodies, production methods; for stimulating hematopoiesis.

ZymoGenetics WO 00/68386

Autotaxin variants


Autotaxin variants, functional fragments, encoding gene sequences; for treating diabetes and obesity.